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Cited by 158

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Amantadine use associated with impulse control disorders in Parkinson disease in cross‐sectional study

Weintraub, Daniel, Sohr, Mandy, Potenza, Marc N., Siderowf, Andrew D., Stacy, Mark, Voon, Valerie, Whetteckey, Jacqueline, Wunderlich, Glen R., Lang, Anthony E.·2010·Annals of Neurology

Abstract

A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross‐sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD. Ann Neurol 2010

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Metadata

Authors
Weintraub, D., Sohr, M., Potenza, M. N., Siderowf, A. D., Stacy, M., Voon, V., Whetteckey, J., Wunderlich, G. R., & Lang, A. E.
Venue
Annals of Neurology
Publisher
Wiley
Published
2010-12
Volume
68
Issue
6
Pages
963-968
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2101307138
Cited by
158
References
2
FWCI
9.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Amantadine use associated with impulse control disorders in Parkinson disease in cross‐sectional study. https://app.cochat.ai/papers/10.1002/ana.22164
The paper
Weintraub, D., Sohr, M., Potenza, M. N., Siderowf, A. D., Stacy, M., Voon, V., Whetteckey, J., Wunderlich, G. R., & Lang, A. E. (2010). Amantadine use associated with impulse control disorders in Parkinson disease in cross‐sectional study. Annals of Neurology. https://doi.org/10.1002/ana.22164

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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