The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Neonatal intensive care unit stress is associated with brain development in preterm infants
Open accessAbstract
Objective: Although many perinatal factors have been linked to adverse neurodevelopmental outcomes in very premature infants, much of the variation in outcome remains unexplained. The impact on brain development of 1 potential factor, exposure to stressors in the neonatal intensive care unit, has not yet been studied in a systematic, prospective manner. Methods: In this prospective cohort study of infants born at <30 weeks gestation, nurses were trained in recording procedures and cares. These recordings were used to derive Neonatal Infant Stressor Scale scores, which were employed to measure exposure to stressors. Magnetic resonance imaging (brain metrics, diffusion, and functional magnetic resonance imaging) and neurobehavioral examinations at term equivalent postmenstrual age were used to assess cerebral structure and function. Simple and partial correlations corrected for confounders, including immaturity and severity of illness, were used to explore these relations. Results: Exposure to stressors was highly variable, both between infants and throughout a single infant's hospital course. Exposure to a greater number of stressors was associated with decreased frontal and parietal brain width, altered diffusion measures and functional connectivity in the temporal lobes, and abnormalities in motor behavior on neurobehavioral examination. Interpretation: Exposure to stressors in the Neonatal Intensive Care Unit is associated with regional alterations in brain structure and function. Further research into interventions that may decrease or mitigate exposure to stressors in the neonatal intensive care unit is warranted. ANN NEUROL 2011;
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Cites
Neonatal MRI to Predict Neurodevelopmental Outcomes in Preterm Infants
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Self-citationRegional brain volume abnormalities and long-term cognitive outcome in preterm infants
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Early experience alters brain function and structure
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Longitudinal Analysis of Neural Network Development in Preterm Infants
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Self-citationThe International Neonatal Network (1993) · The Lancet · doi:10.1016/0140-6736(93)92296-6 · Cited by 773
Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants
Peterson, B. S., Anderson, A. W., Ehrenkranz, R., Staib, L. H., Tageldin, M., Colson, E., Gore, J. C., Duncan, C. C., Makuch, R., & Ment, L. R. (2003) · Pediatrics · doi:10.1542/peds.111.5.939 · Cited by 451
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Perinatal risk factors altering regional brain structure in the preterm infant
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Cited by
White matter injury in the preterm infant: pathology and mechanisms
Back, S. A. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1718-6 · Cited by 473
Rich-club organization of the newborn human brain
Ball, G., Aljabar, P., Zebari, S., Tusor, N., Arichi, T., Merchant, N., Robinson, E. C., Ogundipe, E., Rueckert, D., Edwards, A. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324118111 · Cited by 360
Brain injury in premature neonates: A primary cerebral dysmaturation disorder?
Back, S. A., & Miller, S. P. (2014) · Annals of Neurology · doi:10.1002/ana.24132 · Cited by 360
Dysmaturation of Premature Brain: Importance, Cellular Mechanisms, and Potential Interventions
Volpe, J. J. (2019) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2019.02.016 · Cited by 359
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Self-citation
Metadata
- Authors
- Smith, G. C., Gutovich, J., Smyser, C., Pineda, R., Newnham, C., Tjoeng, T. H., Vavasseur, C., Wallendorf, M., Neil, J., & Inder, T.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-10
- Volume
- 70
- Issue
- 4
- Pages
- 541-549
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2010100154
- Cited by
- 549
- References
- 26
- FWCI
- 24.44
- Type
- journal article
- Language
- en
- Open access
- green
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