The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Perinatal risk factors altering regional brain structure in the preterm infant
Abstract
Neuroanatomical structure appears to be altered in preterm infants, but there has been little insight into the major perinatal risk factors associated with regional cerebral structural alterations. MR images were taken to quantitatively compare regional brain tissue volumes between term and preterm infants and to investigate associations between perinatal risk factors and regional neuroanatomical alterations in a large cohort of preterm infants. In a large prospective longitudinal cohort study of 202 preterm and 36 term infants, MR scans at term equivalent were undertaken for volumetric estimates of cortical and deep nuclear grey matter, unmyelinated and myelinated white matter (WM) and CSF within 8 parcellated regions for each hemisphere of the brain. Perinatal correlates analysed in relation to regional brain structure included gender, gestational age, intrauterine growth restriction, bronchopulmonary dysplasia, white matter injury (WMI) and intraventricular haemorrhage. Results revealed region-specific reductions in brain volumes in preterm infants compared with term controls in the parieto-occipital (preterm mean difference: -8.1%; 95% CI = -13.8--2.3%), sensorimotor (-11.6%; -18.2--5.0%), orbitofrontal (-30.6%; -49.8--11.3%) and premotor (-7.6%; -14.2--0.9%) regions. Within the sensorimotor and orbitofrontal regions cortical grey matter and unmyelinated WM were most clearly reduced in preterm infants, whereas deep nuclear grey matter was reduced mainly within the parieto-occipital and subgenual regions. CSF (ventricular and extracerebral) was doubled in volume within the superior regions in preterm infants compared with term controls. Cerebral WMI and intrauterine growth restriction were both associated with a more posterior reduction in brain volumes, whereas bronchopulmonary dysplasia was associated with a more global reduction across all regions. In contrast degree of immaturity was not related to regional brain structure among preterm infants. In summary, preterm birth is associated with regional cerebral tissue reductions, with the adverse pattern varying between risk factors. These findings add to our understanding of the potential pathways leading to altered brain structure and outcome in the preterm infant.
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Citations
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“During the third trimester, brain development proceeds in a systematic rostro-caudal progression (Rakic, 1988) with the pace of brain maturation varying by brain region (Huttenlocher and Dabholkar, 1997), suggesting that some brain regions may be more vulnerable to alteration with preterm birth.”
BackgroundEarly experience alters brain function and structure
Als, H., Duffy, F. H., McAnulty, G. B., Rivkin, M. J., Vajapeyam, S., Mulkern, R. V., Warfield, S. K., Huppi, P. S., Butler, S. C., Conneman, N., et al. (2004) · Pediatrics · doi:10.1542/peds.113.4.846 · Cited by 890
Self-citationThe Human Brain Age 7–11 Years: A Volumetric Analysis Based on Magnetic Resonance Images
Caviness, V. S., Kennedy, D. N., Richelme, C., Rademacher, J., & Filipek, P. A. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.5.726 · Cited by 509
Adolescents who were born very preterm have decreased brain volumes
Nosarti, C. (2002) · Brain · doi:10.1093/brain/awf157 · Cited by 406
Regional Brain and Ventricular Volumes in Tourette Syndrome
Peterson, B. S., Staib, L., Scahill, L., Zhang, H., Anderson, C., Leckman, J. F., Cohen, D. J., Gore, J. C., Albert, J., & Webster, R. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.427 · Cited by 312 · cited 1×
“In order to make regional comparisons, the previously described and validated Talairach scheme was utilized (Peterson et al., 2000, 2001).”
MethodQuantitative magnetic resonance imaging of the brain in survivors of very low birth weight
Abernethy, L. J. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.87.4.279 · Cited by 157
Cited by
Neonatal intensive care unit stress is associated with brain development in preterm infants
Smith, G. C., Gutovich, J., Smyser, C., Pineda, R., Newnham, C., Tjoeng, T. H., Vavasseur, C., Wallendorf, M., Neil, J., & Inder, T. (2011) · Annals of Neurology · doi:10.1002/ana.22545 · Cited by 549
Self-citationBrain injury in premature neonates: A primary cerebral dysmaturation disorder?
Back, S. A., & Miller, S. P. (2014) · Annals of Neurology · doi:10.1002/ana.24132 · Cited by 360
Fanaroff, A. A. (2008) · Yearbook of Neonatal and Perinatal Medicine · doi:10.1016/s8756-5005(08)79272-2 · Cited by 365
Mapping Region-Specific Longitudinal Cortical Surface Expansion from Birth to 2 Years of Age
Li, G., Nie, J., Wang, L., Shi, F., Lin, W., Gilmore, J. H., & Shen, D. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs265 · Cited by 220
Rivkin, M. J., Davis, P. E., Lemaster, J. L., Cabral, H. J., Warfield, S. K., Mulkern, R. V., Robson, C. D., Rose-Jacobs, R., & Frank, D. A. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1399 · Cited by 172
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Metadata
- Authors
- Thompson, D. K., Warfield, S. K., Carlin, J. B., Pavlovic, M., Wang, H. X., Bear, M., Kean, M. J., Doyle, L. W., Egan, G. F., & Inder, T. E.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-28
- Volume
- 130
- Issue
- 3
- Pages
- 667-677
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2017311476
- Cited by
- 320
- References
- 6
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, D. K., Warfield, S. K., Carlin, J. B., Pavlovic, M., Wang, H. X., Bear, M., Kean, M. J., Doyle, L. W., Egan, G. F., & Inder, T. E. (2007). Perinatal risk factors altering regional brain structure in the preterm infant. Brain. https://doi.org/10.1093/brain/awl277
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