The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Solvent exposures and parkinson disease risk in twins
Open accessAbstract
Objective: Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design. Methods: Ninety‐nine twin pairs discordant for PD ascertained from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job task–specific questionnaires. Exposures to 6 specific solvents selected a priori were estimated by expert raters unaware of case status. Results: Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (odds ratio [OR], 6.1; 95% confidence interval [CI] 1.2–33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl 4 ) tended toward significance (respectively: OR, 10.5; 95% CI, 0.97–113; p = 0.053; OR, 2.3; 95% CI, 0.9–6.1; p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure. Interpretation: Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl 4 are also ubiquitous in the environment. Our findings require replication in other populations with well‐characterized exposures, but the potential public health implications are substantial. ANN NEUROL 2011
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Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Potential occupational risks for neurodegenerative diseases
Park, R. M., Schulte, P. A., Bowman, J. D., Walker, J. T., Bondy, S. C., Yost, M. G., Touchstone, J. A., & Dosemeci, M. (2005) · American Journal of Industrial Medicine · doi:10.1002/ajim.20178 · Cited by 256
Cited by
Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology
Simon, D. K., Tanner, C. M., & Brundin, P. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.08.002 · Cited by 1,114
Self-citationEpidemiology of Parkinson's disease
Elbaz, A., Carcaillon, L., Kab, S., & Moisan, F. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2015.09.012 · Cited by 445
Ilieva, N. M., Wallen, Z. D., & De Miranda, B. R. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116176 · Cited by 31
Metadata
- Authors
- Goldman, S. M., Quinlan, P. J., Ross, G. W., Marras, C., Meng, C., Bhudhikanok, G. S., Comyns, K., Korell, M., Chade, A. R., Kasten, M., Priestley, B., Chou, K. L., Fernandez, H. H., Cambi, F., Langston, J. W., & Tanner, C. M.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-11-14
- Volume
- 71
- Issue
- 6
- Pages
- 776-784
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1991231955
- Cited by
- 187
- References
- 3
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goldman, S. M., Quinlan, P. J., Ross, G. W., Marras, C., Meng, C., Bhudhikanok, G. S., Comyns, K., Korell, M., Chade, A. R., Kasten, M., Priestley, B., Chou, K. L., Fernandez, H. H., Cambi, F., Langston, J. W., & Tanner, C. M. (2012). Solvent exposures and parkinson disease risk in twins. Annals of Neurology. https://doi.org/10.1002/ana.22629
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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