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Effect of lifestyle activities on alzheimer disease biomarkers and cognition
Open accessAbstract
Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)‐positron emission tomography (PET), neuronal dysfunction via 18 F‐fluorodeoxyglucose (FDG)‐PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population‐based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB‐PET uptake, and global FDG‐PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods—partial correlation analysis adjusted for age and gender and path analysis using structural equations—to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p < 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p < 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology. ANN NEUROL 2012;72:730–738
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“Population-based studies using biomarkers also show that mid-life risk factors (obesity, smoking, diabetes, hypertension, and cardiac disease) commonly found to be associated with cognitive decline and clinically ascertained impairment that is labeled “AD” dementia are associated with neurodegeneration but not amyloid pathology [183].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [183]
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Metadata
- Authors
- Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Roberts, R. O., Lowe, V. J., Kantarci, K., Senjem, M. L., Gunter, J. L., Boeve, B. F., Petersen, R. C., & Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Vemuri, Prashanthi
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2012-11
- Volume
- 72
- Issue
- 5
- Pages
- 730-738
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC3539211
- OpenAlex
- W1974934145
- Cited by
- 193
- References
- 42
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 26 · 2021: 11 · 2020: 11 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 5
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG11378, P50‐AG16574, U01AG06786, K99 AG37573, U01AG006786, K99AG037573, R01AG011378, R01AG041851, P50AG016574)
- National Center for Research Resources (C06RR018898)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, lifestyle habits, intellectual activity, physical activity, cognitive function, amyloid-beta, Pittsburgh compound B PET, FDG-PET, hippocampal volume, neurodegeneration, mild cognitive impairment, non-demented elderly, APOE genotype, Mayo Clinic Study of Aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Models, Biological, Motor Activity, Neuropsychological Tests, Surveys and Questionnaires, Sex Factors, Statistics as Topic, Amyloid beta-Peptides, Principal Component Analysis, Positron-Emission Tomography
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