Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study
Open accessAbstract
BACKGROUND: Physical exercise is associated with decreased risk of dementia and Alzheimer disease. OBJECTIVE: To investigate whether physical exercise is associated with decreased risk of mild cognitive impairment (MCI). DESIGN: Population-based case-control study. SETTING: The Mayo Clinic Study of Aging, an ongoing population-based cohort study in Olmsted County, Minnesota. PARTICIPANTS: A total of 1324 subjects without dementia who completed a Physical Exercise Questionnaire. MAIN OUTCOME MEASURES: An expert consensus panel classified each subject as having normal cognition or MCI based on published criteria. RESULTS: We compared the frequency of physical exercise among 198 subjects with MCI with that among 1126 subjects with normal cognition and adjusted the analyses for age, sex, years of education, medical comorbidity, and depression. The odds ratios for any frequency of moderate exercise were 0.61 (95% confidence interval, 0.43-0.88; P = .008) for midlife (age range, 50-65 years) and 0.68 (95% confidence interval, 0.49-0.93; P = .02) for late life. The findings were consistent among men and women. Light exercise and vigorous exercise were not significantly associated with decreased risk of MCI. CONCLUSION: In this population-based case-control study, any frequency of moderate exercise performed in midlife or late life was associated with a reduced odds of having MCI.
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Early-life and midlife exercise reduces the subsequent risk of mild cognitive impairment.
“Early-life and midlife exercise reduces the subsequent risk of MCI.20 -23”
From Does vigorous exercise have a neuroprotective effect in Parkinson disease? (2011) · cites this paper as [22]
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Self-citation
- Authors
- Geda, Y. E., Roberts, R. O., Knopman, D. S., Christianson, T. J. H., Pankratz, V. S., Ivnik, R. J., Boeve, B. F., Tangalos, E. G., Petersen, R. C., & Rocca, W. A.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2010-01-01
- Volume
- 67
- Issue
- 1
- Pages
- 80-6
- ISSN
- 0003-9942 (ISSN-L)
- PMC
- PMC2919839
- OpenAlex
- W2052104903
- Cited by
- 371
- References
- 56
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 16 · 2023: 16 · 2022: 13 · 2021: 23 · 2020: 27 · 2019: 18 · 2018: 26 · 2017: 25 · 2016: 18 · 2015: 29 · 2014: 28 · 2013: 24 · 2012: 39
- FWCI
- 25.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (U01AG006786, K01AG028573, P50AG016574)
- National Institute of Mental Health (K01MH068351)
- National Institute of Neurological Disorders and Stroke (R01NS033978)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- physical activity, mild cognitive impairment, aging, moderate-intensity exercise, midlife, old age, dementia risk, Alzheimer's disease, Mayo Clinic Study of Aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cognition Disorders, Depressive Disorder, Exercise Therapy, Female, Humans, Male, Middle Aged, Physical Fitness, Cohort Studies, Odds Ratio, Case-Control Studies, Treatment Outcome, Sex Distribution, Risk Reduction Behavior
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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