Cited by 193Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Effect of lifestyle activities on alzheimer disease biomarkers and cognition

Open access

Vemuri, Prashanthi, Lesnick, Timothy G., Przybelski, Scott A., Knopman, David S., Roberts, Rosebud O., Lowe, Val J., Kantarci, Kejal, Senjem, Mathew L., Gunter, Jeffrey L., Boeve, Bradley F., Petersen, Ronald C., Jack, Clifford R.·2012·Annals of Neurology

DOI 10.1002/ana.23665PMC PMC3539211

Open this paper in CoChat — free account

Abstract

Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)‐positron emission tomography (PET), neuronal dysfunction via 18 F‐fluorodeoxyglucose (FDG)‐PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population‐based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB‐PET uptake, and global FDG‐PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods—partial correlation analysis adjusted for age and gender and path analysis using structural equations—to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p < 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p < 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology. ANN NEUROL 2012;72:730–738

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/ana.23665

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single subject brain
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Self-citation
The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods
Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P. J., L. Whitwell, J., Ward, C., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21049 · Cited by 4,347
Self-citation
Automatically Parcellating the Human Cerebral Cortex
Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208
Leisure Activities and the Risk of Dementia in the Elderly
Verghese, J., Lipton, R. B., Katz, M. J., Hall, C. B., Derby, C. A., Kuslansky, G., Ambrose, A. F., Sliwinski, M., & Buschke, H. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022252 · Cited by 1,961
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434
Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,352
The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.
Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.03.019 · Cited by 1,223
Effects of Aerobic Exercise on Mild Cognitive Impairment: A Controlled Trial
Baker, L. D., Frank, L. L., Foster-Schubert, K., Green, P. S., Wilkinson, C. W., McTiernan, A., Plymate, S. R., Fishel, M. A., Watson, G. S., Cholerton, B. A., et al. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.307 · Cited by 1,171
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
Jack, C. R., Lowe, V. J., Weigand, S. D., Wiste, H. J., Senjem, M. L., Knopman, D. S., Shiung, M. M., Gunter, J. L., Boeve, B. F., Kemp, B. J., et al. (2009) · Brain · doi:10.1093/brain/awp062 · Cited by 1,099
Self-citation

Show all 42 references

Research works printed but not linked: 1

10.1037/0882-7974.14.2.245 · DOI · Paper page

Sorted by citations

NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
“Population-based studies using biomarkers also show that mid-life risk factors (obesity, smoking, diabetes, hypertension, and cardiac disease) commonly found to be associated with cognitive decline and clinically ascertained impairment that is labeled “AD” dementia are associated with neurodegeneration but not amyloid…”
Self-citation
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396
Self-citation
Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences
Mielke, M., Vemuri, P., & Rocca, W. (2014) · Clinical Epidemiology · doi:10.2147/clep.s37929 · Cited by 1,021
Self-citation
How Does it STAC Up? Revisiting the Scaffolding Theory of Aging and Cognition
Reuter‐Lorenz, P. A., & Park, D. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9270-9 · Cited by 1,054
The bilingual adaptation: How minds accommodate experience
Bialystok, E. (2017) · Psychological Bulletin · doi:10.1037/bul0000099 · Cited by 906
What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus
Fjell, A. M., McEvoy, L., Holland, D., Dale, A. M., & Walhovd, K. B. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.004 · Cited by 799
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
Ossenkoppele, R., Pichet Binette, A., Groot, C., Smith, R., Strandberg, O., Palmqvist, S., Stomrud, E., Tideman, P., Ohlsson, T., Jögi, J., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02049-x · Cited by 496
Self-citation
Defining Cognitive Reserve and Implications for Cognitive Aging
Pettigrew, C. A., & Soldan, A. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0917-z · Cited by 484
Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Preboske, G. M., Kantarci, K., Raman, M. R., Machulda, M. M., Mielke, M. M., Lowe, V. J., et al. (2015) · Brain · doi:10.1093/brain/awu393 · Cited by 299
Self-citation
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 322
Physical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D. F., Cook, D. B., Koscik, R. L., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000964 · Cited by 235
Association of Lifetime Intellectual Enrichment With Cognitive Decline in the Older Population
Vemuri, P., Lesnick, T. G., Przybelski, S. A., Machulda, M. M., Knopman, D. S., Mielke, M. M., Roberts, R. O., Geda, Y. E., Rocca, W. A., Petersen, R. C., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.963 · Cited by 249
Self-citation
The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease
Liu, Z., Li, T., Li, P., Wei, N., Zhao, Z., Liang, H., Ji, X., Chen, W., Xue, M., & Wei, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/352723 · Cited by 221
Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia
Carvalho, D. Z., Louis, E. K. S., Knopman, D. S., Boeve, B. F., Lowe, V. J., Roberts, R. O., Mielke, M. M., Przybelski, S. A., Machulda, M. M., Petersen, R. C., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0049 · Cited by 216
Self-citation
Causes and Patterns of Dementia: An Update in the Era of Redefining Alzheimer's Disease
James, B. D., & Bennett, D. A. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040218-043758 · Cited by 213
Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies
Swomley, A. M., Förster, S., Keeney, J. T. R., Triplett, J. C., Zhang, Z., Rukhsana Sultana, A., & Butterfield, D. A. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.015 · Cited by 194
Sex and Gender Driven Modifiers of Alzheimer’s: The Role for Estrogenic Control Across Age, Race, Medical, and Lifestyle Risks
Rahman, A., Jackson, H. C., Hristov, H., Isaacson, R., Saif, N., Shetty, T., Etingin, O. R., Henchcliffe, C., Brinton, R. D., & Mosconi, L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00315 · Cited by 204
Sex and gender differences in the causes of dementia: A narrative review
Rocca, W. A., Mielke, M. M., Vemuri, P., & Miller, V. M. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.05.008 · Cited by 186
Self-citation
Promoting Successful Cognitive Aging: A Ten-Year Update
Krivanek, T. J., Gale, S. A., McFeeley, B. M., Nicastri, C. M., & Daffner, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201462 · Cited by 189
Cognitive reserve and lifestyle: moving towards preclinical Alzheimer’s disease
Arenaza‐Urquijo, E. M., Wirth, M., & Chételat, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00134 · Cited by 180
Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults
Rabin, J. S., Klein, H., Kirn, D. R., Schultz, A. P., Yang, H., Hampton, O. L., Jiang, S., Buckley, R. F., Viswanathan, A., Hedden, T., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1879 · Cited by 164
Is Alzheimer’s Disease Risk Modifiable?
Serrano‐Pozo, A., & Growdon, J. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad181028 · Cited by 169
Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals
Vemuri, P., Knopman, D. S., Lesnick, T. G., Przybelski, S. A., Mielke, M. M., Graff‐Radford, J., Murray, M. E., Roberts, R. O., Vassilaki, M. E., Lowe, V. J., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0244 · Cited by 144
Self-citation
Gene-Environment Interactions: Lifetime Cognitive Activity, APOE Genotype, and Beta-Amyloid Burden
Wirth, M., Villeneuve, S., Joie, R. L., Marks, S. M., & Jagust, W. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4612-13.2014 · Cited by 139
Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults
Wirth, M., Haase, C. M., Villeneuve, S., Vogel, J. W., & Jagust, W. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.015 · Cited by 138
Leisure Activities and the Risk of Dementia
Su, S., Shi, L., Zheng, Y., Sun, Y., Huang, X., Zhang, A., Que, J., Sun, X., Shi, J., Bao, Y., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200929 · Cited by 121
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Ríos, J. A., Cisternas, P., Arrese, M. A., Salesa Barja, Y., & Inestrosa, N. C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.07.004 · Cited by 107
Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation
Arenaza‐Urquijo, E. M., Bejanin, A., Gonneaud, J., Wirth, M., Joie, R. L., Mutlu, J., Gaubert, M., Landeau, B., Sayette, V. D. L., Eustache, F., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.016 · Cited by 100
Neuropathological approaches to cerebral aging and neuroplasticity
Jellinger, K. A., & Attems, J. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/kjellinger · Cited by 94
Epidemiology of Alzheimer’s Disease and Dementia in Arab Countries: A Systematic Review
El‐Metwally, A., Toivola, P., Al-Rashidi, M., Nooruddin, S., Jawed, M., Alkanhal, R., Razzak, H. A., & Albawardi, N. M. (2019) · Behavioural Neurology · doi:10.1155/2019/3935943 · Cited by 85
Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly
Fatemi, F., Kantarci, K., Graff‐Radford, J., Preboske, G. M., Weigand, S. D., Przybelski, S. A., Knopman, D. S., Machulda, M. M., Roberts, R. O., Mielke, M. M., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000004913 · Cited by 85
Self-citation
Effect of intellectual enrichment on AD biomarker trajectories
Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Machulda, M. M., Lowe, V. J., Mielke, M. M., Roberts, R. O., Gunter, J. L., Senjem, M. L., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002490 · Cited by 88
Self-citation
Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area
Mosconi, L., Walters, M., Sterling, J. L., Quinn, C. G., McHugh, P. F., Andrews, R. D., Matthews, D. C., Ganzer, C. A., Osorio, R. S., Isaacson, R., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019362 · Cited by 86
Cognitive reserve and cortical thickness in preclinical Alzheimer’s disease
Pettigrew, C. A., Soldan, A., Zhu, Y., Wang, M., Brown, T., Miller, M. I., & Albert, M. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9581-y · Cited by 86
The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms
de Vries, L. E., Huitinga, I., Kessels, H. W. H. G., Swaab, D. F., & Verhaagen, J. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00719-7 · Cited by 85
Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
Vemuri, P., Lesnick, T. G., Przybelski, S. A., Graff‐Radford, J., Reid, R. I., Lowe, V. J., Zuk, S. M., Senjem, M. L., Schwarz, C. G., Gunter, J. L., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25346 · Cited by 75
Self-citation
Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging
Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff‐Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25600 · Cited by 74
Self-citation
Lifestyle and health‐related risk factors and risk of cognitive aging among older veterans
Yaffe, K. S., Hoang, T. D. M., Byers, A. L., Barnes, D. E., & Friedl, K. E. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.010 · Cited by 75
Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease
Schultz, S. A., Larson, J., Oh, J. M., Koscik, R. L., Dowling, N. M., Gallagher, C. L., Carlsson, C. M., Rowley, H. A., Bendlin, B. B., Asthana, S., et al. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9329-5 · Cited by 74
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer’s: A Multi-Modality Brain Imaging Study
Matthews, D. C., Davies, M., Murray, J., Williams, S., Tsui, W. H., Li, Y., Andrews, R. D., Lukic, A., McHugh, P. F., Vallabhajosula, S., et al. (2014) · Advances in Molecular Imaging · doi:10.4236/ami.2014.44006 · Cited by 70
Distinct effects of late adulthood cognitive and physical activities on gray matter volume
Arenaza‐Urquijo, E. M., de Florès, R., Gonneaud, J., Wirth, M., Ourry, V., Callewaert, W., Landeau, B., Egret, S., Mézenge, F., Desgranges, B., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9617-3 · Cited by 72
Adapting the concepts of brain and cognitive reserve to post-stroke cognitive deficits: Implications for understanding neglect
Umarova, R. M. (2016) · Cortex · doi:10.1016/j.cortex.2016.12.006 · Cited by 72
The role of education in a vascular pathway to episodic memory: brain maintenance or cognitive reserve?
Zahodne, L. B., Mayeda, E. R., Hohman, T. J., Fletcher, E., Racine, A. M., Gavett, B. E., Manly, J. J., Schupf, N., Mayeux, R. P., Brickman, A. M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.009 · Cited by 72
Leisure‐time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study
Palta, P., Sharrett, A. R., Deal, J. A., Evenson, K. R., Gabriel, K. P., Folsom, A. R., Gross, A. L., Windham, B. G., Knopman, D. S., Mosley, T. H., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.08.008 · Cited by 73
Self-citation
Aerobic exercise, cardiorespiratory fitness, and the human hippocampus
Aghjayan, S. L., Lesnovskaya, A., Esteban‐Cornejo, I., Peven, J. C., Stillman, C. M., & Erickson, K. I. (2021) · Hippocampus · doi:10.1002/hipo.23337 · Cited by 69
Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition
Schultz, S. A., Boots, E. A., Almeida, R. P., Oh, J. M., Einerson, J. A., Korcarz, C. E., Edwards, D. F., Koscik, R. L., Dowling, N. M., Gallagher, C. L., et al. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000843 · Cited by 65
The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease
Ojala, J. O., & Sutinen, E. M. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6050055 · Cited by 64
Sex and Gender Differences in Alzheimer’s Disease: Genetic, Hormonal, and Inflammation Impacts
Kolahchi, Z., Henkel, N., Eladawi, M. A., Villarreal, E. C., Kandimalla, P., Lundh, A., McCullumsmith, R. E., & Cuevas, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158485 · Cited by 66
Prevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise
McGurran, H., Glenn, J. M., Madero, E. N., & Bott, N. T. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180958 · Cited by 63
Clinical Amyloid Imaging
Mallik, A. K., Drzezga, A. E., & Minoshima, S. (2016) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.09.005 · Cited by 64
Association Between Later Life Lifestyle Factors and Alzheimer’s Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study
Reijs, B. L. R., Vos, S. J. B., Soininen, H. S., Lötjönen, J. M. P., Koikkalainen, J. R., Pikkarainen, M., Hall, A., Vanninen, R. L., Liu, Y., Herukka, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170039 · Cited by 60
Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status
Machulda, M. M., Hagen, C. E., Wiste, H. J., Mielke, M. M., Knopman, D. S., Roberts, R. O., Vemuri, P., Lowe, V. J., Jack, C. R., & Petersen, R. C. (2016) · The Clinical Neuropsychologist · doi:10.1080/13854046.2016.1241303 · Cited by 63
Self-citation
Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers
Gidicsin, C. M., Maye, J. E., Locascio, J. J., Pepin, L. C., Philiossaint, M., Becker, J. A., Younger, A. P., Dekhtyar, M., Schultz, A. P., Amariglio, R. E., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001704 · Cited by 58
A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults
Anatürk, M., Demnitz, N., Ebmeier, K. P., & Sexton, C. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.012 · Cited by 58
Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi‐Ethnic (FLAME) cohort
Santos, O. A., Pedraza, O., Lucas, J. A., Duara, R., Greig‐Custo, M. T., Al‐Shaikh, F. S. H., Liesinger, A. M., Bieniek, K. F., Hinkle, K. M., Lesser, E. R., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.013 · Cited by 54
Cognitive decline and brain pathology in aging – need for a dimensional, lifespan and systems vulnerability view
Walhovd, K. B., Fjell, A. M., & Espeseth, T. (2014) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12120 · Cited by 60
Effects of Different Exercise Strategies and Intensities on Memory Performance and Neurogenesis
Diederich, K., Bastl, A., Wersching, H., Teuber, A., Strecker, J., Schmidt, A., Minnerup, J., & Schäbitz, W. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00047 · Cited by 57
Functional neuroimaging of normal aging: Declining brain, adapting brain
Sugiura, M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.006 · Cited by 52
Alzheimer's disease: Only prevention makes sense
Viña, J., & Sanz‐Ros, J. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13005 · Cited by 55
Cognitive reserve and rate of change in Alzheimer's and cerebrovascular disease biomarkers among cognitively normal individuals
Pettigrew, C. A., Soldan, A., Zhu, Y., Cai, Q., Wang, M., Moghekar, A., Miller, M. I., Singh, B., Martinez, O., Fletcher, E. M., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.003 · Cited by 47
Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis
Rodríguez‐Ayllón, M., Solis‐Urra, P., Arroyo‐Avila, C., Álvarez-Ortega, M., Molina‐García, P., Molina‐Hidalgo, C., Gómez-Río, M., Brown, B. M., Erickson, K. I., & Esteban‐Cornejo, I. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.08.001 · Cited by 50
Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings
Blennow, K., & Zetterberg, H. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.07.006 · Cited by 46
Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study
Kemppainen, N. M., Johansson, J. J., Teuho, J., Parkkola, R. K., Joutsa, J., Ngandu, T., Solomon, A., Stephen, R., Liu, Y., Hänninen, T., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004827 · Cited by 47
Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging
Neth, B. J., Graff‐Radford, J., Mielke, M. M., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Reid, R. I., Senjem, M. L., Lowe, V. J., Machulda, M. M., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00355 · Cited by 48
Self-citation
Is Verbal Episodic Memory in Elderly with Amyloid Deposits Preserved Through Altered Neuronal Function?
Ossenkoppele, R., Madison, C. M., Oh, H., Wirth, M., van Berckel, B. N. M., & Jagust, W. J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht076 · Cited by 45
Associations of lifestyle and vascular risk factors with Alzheimer’s brain biomarker changes during middle age: a 3-year longitudinal study in the broader New York City area
Walters, M., Sterling, J. L., Quinn, C. G., Ganzer, C. A., Osorio, R. S., Andrews, R. D., Matthews, D. C., Vallabhajosula, S., de Leon, M. J., Isaacson, R., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-023664 · Cited by 45
The relevance of beta-amyloid on markers of Alzheimer’s disease in clinically normal individuals and factors that influence these associations
Mormino, E. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9267-4 · Cited by 44
Impact of lifestyle dimensions on brain pathology and cognition
Schreiber, S., Vogel, J. W., Schwimmer, H., Marks, S. M., Schreiber, F., & Jagust, W. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.01.012 · Cited by 45
Prevalence of Mild Cognitive Impairment and Dementia among the Elderly Population of Qena Governorate, Upper Egypt: A Community-Based Study
Khedr, E. M., Fawi, G., Abbas, M. A. A., Mohammed, T. A., Elfetoh, N. A., Al-Attar, G. S. T., Noaman, M. M., & Zaki, A. F. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142655 · Cited by 46
Mild Cognitive Impairment
Anderson, N. D. (2015) · The Encyclopedia of Adulthood and Aging · doi:10.1002/9781118521373.wbeaa244 · Cited by 44
Risk factors for age at onset of dementia due to Alzheimer's disease in a sample of patients with low mean schooling from São Paulo, Brazil
de Oliveira, F. F., Bertolucci, P. H. F., Chen, E., & Smith, M. D. A. C. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4094 · Cited by 41
Physical Activity and Amyloid‐ β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment
Barreto, P. D. S., Andrieu, S., Payoux, P., Demougeot, L., Rolland, Y., Vellas, B. J., & the Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer Study Group (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13530 · Cited by 42
Sex Differences in Alzheimer’s Disease: Where Do We Stand?
Medeiros, A. D. M., & Silva, R. H. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180213 · Cited by 42
Physical Activity as a Moderator of Alzheimer Pathology: A Systematic Review of Observational Studies
Frederiksen, K. S., Gjerum, L., Waldemar, G., & Hasselbalch, S. G. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190315095151 · Cited by 43
Cognitively Engaging Activity Is Associated with Greater Cortical and Subcortical Volumes
Seider, T. R., Fieo, R. A., O’Shea, A. M., Porges, E. C., Woods, A. J., & Cohen, R. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00094 · Cited by 42
Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment
Kimura, N., Aso, Y., Yabuuchi, K., Ishibashi, M., Hori, D., Sasaki, Y., Nakamichi, A., Uesugi, S., Jikumaru, M., Sumi, K., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.5719 · Cited by 37
A TgCRND8 Mouse Model of Alzheimer’s Disease Exhibits Sexual Dimorphisms in Behavioral Indices of Cognitive Reserve
Granger, M. W., Franko, B., Taylor, M. W., Messier, C., George‐Hyslop, P. S., & Bennett, S. A. L. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150587 · Cited by 41
Association of Lifestyle Activities with Functional Brain Connectivity and Relationship to Cognitive Decline among Older Adults
Soldan, A., Pettigrew, C. A., Zhu, Y., Wang, M., Bilgel, M., Hou, X., Lu, H., Miller, M. I., & Albert, M. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab187 · Cited by 37
Alzheimer's Disease—Current Status and Future Directions
Bhardwaj, D., Mitra, C., Narasimhulu, C. A., Riad, A., Doomra, M., & Parthasarathy, S. (2017) · Journal of Medicinal Food · doi:10.1089/jmf.2017.0093 · Cited by 37
How Do Cognitively Stimulating Activities Affect Cognition and the Brain Throughout Life?
Mather, M. (2020) · Psychological Science in the Public Interest · doi:10.1177/1529100620941808 · Cited by 36
Cognitive Disparities: The Impact of the Great Depression and Cumulative Inequality on Later-Life Cognitive Function
Hale, J. M. (2017) · Demography · doi:10.1007/s13524-017-0629-4 · Cited by 35
Alzheimer’s Biomarkers From Multiple Modalities Selectively Discriminate Clinical Status: Relative Importance of Salivary Metabolomics Panels, Genetic, Lifestyle, Cognitive, Functional Health and Demographic Risk Markers
Sapkota, S., Huan, T., Tran, T., Zheng, J., Camicioli, R. M., Li, L., & Dixon, R. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00296 · Cited by 36
Associations between social health factors, cognitive activity and neurostructural markers for brain health – A systematic literature review and meta-analysis
Duffner, L. A., DeJong, N. R., Jansen, J. F. A., Backes, W. H., de Vugt, M. E., Deckers, K., & Köhler, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101986 · Cited by 35
A perspective on the future role of brain pet imaging in exercise science
Boecker, H., & Drzezga, A. E. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.021 · Cited by 37
Cognitive interventions in Alzheimer's and Parkinson's diseases: emerging mechanisms and role of imaging
Vemuri, P., Fields, J. A., Peter, J., & Klöppel, S. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000346 · Cited by 36
Self-citation
EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development
Wiegand, I., Lauritzen, M., Osler, M., Mortensen, E. L., Rostrup, E., Rask, L., Richard, N., Horwitz, A., Benedek, K., Vangkilde, S., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.018 · Cited by 33
Engagement in Lifestyle Activities is Associated with Increased Alzheimer’s Disease-Associated Cortical Thickness and Cognitive Performance in Older Adults
Bae, S., Lee, S., Harada, K., Makino, K., Chiba, I., Katayama, O., Shinkai, Y., Park, H., & Shimada, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051424 · Cited by 31
Early-Life Cognitive Activity Is Related to Reduced Neurodegeneration in Alzheimer Signature Regions in Late Life
Ko, K., Byun, M. S., Yi, D., Lee, J. H., Kim, C. H., & Lee, D. Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00070 · Cited by 31
Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women
Bachmann, D., Roman, Z. J., Buchmann, A., Zuber, I., Studer, S. T., Saake, A., Rauen, K., Gruber, E., Nitsch, R. M., Höck, C., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26417 · Cited by 31
Mechanisms of processing speed training and transfer effects across the adult lifespan: protocol of a multi-site cognitive training study
von Bastian, C. C., Reinhartz, A., Udale, R. C., Grégoire, S., Essounni, M., Belleville, S., & Strobach, T. (2022) · BMC Psychology · doi:10.1186/s40359-022-00877-7 · Cited by 36
Independent and combined effects of cognitive and physical activity on incident MCI
Hughes, T. F., Becker, J. T., Lee, C., Chang, C. H., & Ganguli, M. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.11.007 · Cited by 31
The application of weighted gene co-expression network analysis in identifying key modules and hub genes associated with disease status in Alzheimer’s disease
Sun, Y., Lin, J., & Zhang, L. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.12.59 · Cited by 31
Effects of Aerobic Training on Cognition and Brain Glucose Metabolism in Subjects with Mild Cognitive Impairment
Porto, F. H. D. G., Coutinho, A. M., Pinto, A. L. D. S., Gualano, B., Duran, F., Prando, S., Ono, C. R., Spíndola, L., de Oliveira, M. O., do Vale, P. H. F., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150033 · Cited by 34
How Do Modifiable Risk Factors Affect Alzheimer’s Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?
Ourry, V., Binette, A. P., St‐Onge, F., Strikwerda‐Brown, C., Chagnot, A., Poirier, J., Breitner, J. C. S., Arenaza‐Urquijo, E. M., Rabin, J. S., Buckley, R. F., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.003 · Cited by 30
Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer’s disease
Yang, H. J., Kwon, D. Y., Kim, M. J., Kang, S., Moon, N. R., Daily, J. W., & Park, S. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0005-6 · Cited by 29
Education as a Moderator of the Relationship Between Episodic Memory and Amyloid Load in Normal Aging
Joannette, M., Bocti, C., Sévigny-Dupont, P., Lavallée, M. M., Nikelski, J., Vallet, G. T., Chertkow, H. M., & Joubert, S. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz235 · Cited by 27
Factor structure of the ARIC-NCS Neuropsychological Battery: An evaluation of invariance across vascular factors and demographic characteristics.
Rawlings, A. M., Bandeen‐Roche, K., Gross, A. L., Gottesman, R. F., Coker, L. H., Penman, A. D., Sharrett, A. R., & Mosley, T. H. (2016) · Psychological Assessment · doi:10.1037/pas0000293 · Cited by 27
The Impact of Sustained Ownership of a Pet on Cognitive Health: A Population-Based Study
Applebaum, J. W., Shieu, M. M., McDonald, S. E., Dunietz, G. L., & Braley, T. J. (2022) · Journal of Aging and Health · doi:10.1177/08982643221122641 · Cited by 27
Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults
Felisatti, F., Gonneaud, J., Palix, C., Garnier-Crussard, A., Mézenge, F., Landeau, B., Chocat, A., Quillard, A., Ferrand-Devouge, E., de La Sayette, V., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200270 · Cited by 26

Authors: Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Roberts, R. O., Lowe, V. J., Kantarci, K., Senjem, M. L., Gunter, J. L., Boeve, B. F., Petersen, R. C., & Jack, C. R.
Affiliations: Mayo Clinic (US)
Corresponding author: Vemuri, Prashanthi
ORCID: Vemuri, Prashanthi
Lesnick, Timothy G.
Przybelski, Scott A.
Knopman, David S.
Lowe, Val J.
Kantarci, Kejal
Gunter, Jeffrey L.
Boeve, Bradley F.
Petersen, Ronald C.
Jack, Clifford R.
Venue: Annals of Neurology
Publisher: Wiley
Published: 2012-11
Volume: 72
Issue: 5
Pages: 730-738
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.23665
PMC: PMC3539211
OpenAlex: W1974934145
Cited by: 193
References: 42
Citations by year: 2026: 3 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 26 · 2021: 11 · 2020: 11 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 16 · 2015: 22 · 2014: 21 · 2013: 5
FWCI: 10.97
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 56 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG11378, P50‐AG16574, U01AG06786, K99 AG37573, U01AG006786, K99AG037573, R01AG011378, R01AG041851, P50AG016574)
National Center for Research Resources (C06RR018898)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Alzheimer's disease, lifestyle habits, intellectual activity, physical activity, cognitive function, amyloid-beta, Pittsburgh compound B PET, FDG-PET, hippocampal volume, neurodegeneration, mild cognitive impairment, non-demented elderly, APOE genotype, Mayo Clinic Study of Aging
MeSH terms: Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Life Style, Magnetic Resonance Imaging, Male, Models, Biological, Motor Activity, Neuropsychological Tests, Surveys and Questionnaires, Sex Factors, Statistics as Topic, Amyloid beta-Peptides, Principal Component Analysis, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of lifestyle activities on alzheimer disease biomarkers and cognition

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks