The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
STAT3‐Mediated astrogliosis protects myelin development in neonatal brain injury
Open accessAbstract
Objective: Pathological findings in neonatal brain injury associated with preterm birth include focal and/or diffuse white matter injury (WMI). Despite the heterogeneous nature of this condition, reactive astrogliosis and microgliosis are frequently observed. Thus, molecular mechanisms by which glia activation contribute to WMI were investigated. Methods: Postmortem brains of neonatal brain injury were investigated to identify molecular features of reactive astrocytes. The contribution of astrogliosis to WMI was further tested in a mouse model in genetically engineered mice. Results: Activated STAT3 signaling in reactive astrocytes was found to be a common feature in postmortem brains of neonatal brain injury. In a mouse model of neonatal WMI, conditional deletion of STAT3 in astrocytes resulted in exacerbated WMI, which was associated with delayed maturation of oligodendrocytes. Mechanistically, the delay occurred in association with overexpression of transforming growth factor (TGF)β‐1 in microglia, which in healthy controls decreased with myelin maturation in an age‐dependent manner. TGFβ‐1 directly and dose‐dependently inhibited the maturation of purified oligodendrocyte progenitors, and pharmacological inhibition of TGFβ‐1 signaling in vivo reversed the delay in myelin development. Factors secreted from STAT3‐deficient astrocytes promoted elevated TGFβ‐1 production in cultured microglia compared to wild‐type astrocytes. Interpretation: These results suggest that myelin development is regulated by a mechanism involving crosstalk between microglia and oligodendrocyte progenitors. Reactive astrocytes may modify this signaling in a STAT3‐dependent manner, preventing the pathological expression of TGFβ‐1 in microglia and the impairment of oligodendrocyte maturation. ANN NEUROL 2012;72:750–765
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“For example, activation of STAT3-dependent transcription is beneficial in neonatal white matter injury47, traumatic brain injury30, spinal cord injury48,49, and motor neuron injury50, but detrimental in AD models42,43.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Self-citationMolecular dissection of reactive astrogliosis and glial scar formation
Sofroniew, M. V. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.08.002 · Cited by 2,594
Self-citationCognitive and Behavioral Outcomes of School-Aged Children Who Were Born Preterm: A Meta-analysis
Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M., & Anand, K. J. S. (2002) · JAMA · doi:10.1001/jama.288.6.728 · Cited by 2,392
Inman, G. J., Nicolás, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J., & Hill, C. S. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.1.65 · Cited by 1,636
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
Self-citationOrigin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972
Self-citationSTAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
Herrmann, J. E., Imura, T., Song, B., Qi, J., Ao, Y., Nguyen, T. K., Korsak, R. A., Takeda, K., Akira, S., & Sofroniew, M. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1709-08.2008 · Cited by 958
Self-citationNeurobiology of Periventricular Leukomalacia in the Premature Infant
Volpe, J. J. (2001) · Pediatric Research · doi:10.1203/00006450-200111000-00003 · Cited by 945
Astrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689
Flagged first, then by citations
Research works printed but not linked: 1
- 10.1093/brain/awm001 · DOI
Cited by
Sorted by citations
Items 101–105 of 105
Lun, J., Li, Y., Gao, X., Gong, Z., Chen, X., Zou, J., Zhou, C., Huang, Y., Zhou, B., Huang, P., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26579180
The Pathogenesis of Preterm Brain Injury
Dean, J. M., Lear, B. A., Bennet, L., & Gunn, A. J. (2026) · Cambridge University Press eBooks · doi:10.1017/9781009418034.005
Zhu, J., Xu, Y., Sun, L., Huang, Z., Yu, W., Zhang, S., Zhang, X., He, T., Chen, Y., Wu, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76341-6
Self-citation
Metadata
- Authors
- Nobuta, H., Ghiani, C. A., Paez, P. M., Spreuer, V., Dong, H., Korsak, R. A., Manukyan, A., Li, J., Vinters, H. V., Huang, E. J., Rowitch, D. H., Sofroniew, M. V., Campagnoni, A. T., de Vellis, J., & Waschek, J. A.
- Affiliations
- University of California, Los Angeles (US)
- San Francisco VA Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Waschek, James A.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2012-08-31
- Volume
- 72
- Issue
- 5
- Pages
- 750-765
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC3514566
- OpenAlex
- W2083567430
- Cited by
- 97
- References
- 64
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 4
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS057624, R01NS057624, R21NS070580, NS070580)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD057557, HD004612, R03HD057557, P30HD004612)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- STAT3, reactive astrogliosis, white matter injury, neonatal brain injury, preterm birth, myelination, oligodendrocyte maturation, oligodendrocyte progenitors, TGF-β1, microglia, astrocyte-microglia crosstalk, glial activation
- MeSH terms
- Age Factors, Animals, Animals, Newborn, Astrocytes, Benzamides, Brain Injuries, Cell Differentiation, Cells, Cultured, Dioxoles, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Gliosis, Humans, Infant, Infant, Newborn, Lipopolysaccharides, Male, Mice, Inbred C57BL, Myelin Sheath, Postmortem Changes, Stem Cells, Signal Transduction, Culture Media, Conditioned, Receptors, Transforming Growth Factor beta, Mice, Knockout, Gene Expression Regulation, Developmental, Cell Proliferation, STAT3 Transcription Factor, Mice, Smad2 Protein, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
