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Cited by 413

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Magnetic resonance imaging improves 3‐month outcome prediction in mild traumatic brain injury

Open access
Yuh, Esther L., Mukherjee, Pratik, Lingsma, Hester F., Yue, John K., Ferguson, Adam R., Gordon, Wayne A., Valadka, Alex B., Schnyer, David M., Okonkwo, David O., Maas, Andrew I. R., Manley, Geoffrey T., the TRACK‐TBI Investigators·2013·Annals of Neurology

Abstract

Objective: To determine the clinical relevance, if any, of traumatic intracranial findings on early head computed tomography (CT) and brain magnetic resonance imaging (MRI) to 3‐month outcome in mild traumatic brain injury (MTBI). Methods: One hundred thirty‐five MTBI patients evaluated for acute head injury in emergency departments of 3 LEVEL I trauma centers were enrolled prospectively. In addition to admission head CT, early brain MRI was performed 12 ± 3.9 days after injury. Univariate and multivariate logistic regression were used to assess for demographic, clinical, socioeconomic, CT, and MRI features that were predictive of Extended Glasgow Outcome Scale (GOS‐E) at 3 months postinjury. Results: Twenty‐seven percent of MTBI patients with normal admission head CT had abnormal early brain MRI. CT evidence of subarachnoid hemorrhage was associated with a multivariate odds ratio of 3.5 (p = 0.01) for poorer 3‐month outcome, after adjusting for demographic, clinical, and socioeconomic factors. One or more brain contusions on MRI, and ≥4 foci of hemorrhagic axonal injury on MRI, were each independently associated with poorer 3‐month outcome, with multivariate odds ratios of 4.5 (p = 0.01) and 3.2 (p = 0.03), respectively, after adjusting for head CT findings and demographic, clinical, and socioeconomic factors. Interpretation: In this prospective multicenter observational study, the clinical relevance of abnormal findings on early brain imaging after MTBI is demonstrated. The addition of early CT and MRI markers to a prognostic model based on previously known demographic, clinical, and socioeconomic predictors resulted in a >2‐fold increase in the explained variance in 3‐month GOS‐E. ANN NEUROL 2013;73:224–235

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Metadata

Authors
Yuh, E. L., Mukherjee, P., Lingsma, H. F., Yue, J. K., Ferguson, A. R., Gordon, W. A., Valadka, A. B., Schnyer, D. M., Okonkwo, D. O., Maas, A. I. R., Manley, G. T., & the TRACK‐TBI Investigators
Venue
Annals of Neurology
Publisher
Wiley
Published
2012-12-07
Volume
73
Issue
2
Pages
224-235
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W1934249711
Cited by
413
References
7
FWCI
18.31
Type
journal article
Language
en
Open access
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