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Cited by 2,609Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesTrauma and Emergency Care Studies

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

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Maas, Andrew I R, Menon, David K, Adelson, P David, Andelic, Nada, Bell, Michael J, Belli, Antonio, Bragge, Peter, Brazinova, Alexandra +327 more·2017·The Lancet Neurology
DOI 10.1016/s1474-4422(17)30371-x
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Abstract

A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world's population will have one or more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries, with a disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has been estimated that TBI costs the global economy approximately $US400 billion annually. Deficiencies in prevention, care, and research urgently need to be addressed to reduce the huge burden and societal costs of TBI. This Commission highlights priorities and provides expert recommendations for all stakeholders—policy makers, funders, health-care professionals, researchers, and patient representatives—on clinical and research strategies to reduce this growing public health problem and improve the lives of people with TBI.

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  • In the general population, excluding individuals with a head injury and alteration (but not loss) of consciousness would miss approximately 80% of all injuries considered to be TBIs by commonly used definitions.

    “In the general population, excluding individuals with a head injury and alteration (but not loss) of consciousness would miss approximately 80% of all injuries considered to be TBIs by commonly used definitions.”

    From Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis (2020) · cites this paper as [5]

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Research works printed but not linked: 33

  1. Fleminger S, Oliver DL, Lovestone S, Rabe-Hesketh S, Giora A. H A 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 2003; 74: 857 62.
  2. Vázquez-Barquero A, Vázquez-Barquero JL, Trigueros F, et al. [Morbidity and mortality in craniocerebral trauma: epidemiologic study in Cantabria]. Neurologia 1990; 5: 265 70.
  3. Koizumi MS, Lebrão ML, Mello-Jorge MH, Primerano V. [Morbidity and mortality due to traumatic brain injury in São Paulo City, Brazil, 1997]. Arq Neuropsiquiatr 2000; 58: 81 89.
  4. Yang YC, Lis SZ, Chung XM, Wang WZ. WSP. The epidemiology of craniocerebral injury in 6 cities of China. Chin J Neurosurg 1987; 3: 23 24.
  5. Huang X. Car ownership modeling and forecast for China. 2011 https://pdfs.semanticscholar.org/39fd/4e7e44e2bd27a3de1a1a7bdbbe16b8576fc7.pdf (accessed March 15, 2017).
  6. Hu J, Yao H, Liu Y, et al. A prospective epidemiological investigation of the hospitalized patients with traumatic brain injury in the Eastern of China. Chinese J Neurosurg 2008; 24: 88 91.
  7. Gururaj G. Road traffic deaths, injuries and disabilities in India: current scenario. Natl Med J India 2008; 21: 14 20.
  8. Faul M, Wald MM, Rutland-Brown W, Sullivent EE, Sattin RW. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing theBrain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. J Trauma 2007; 63: 1271 78. 156
  9. Norton R, Kobusingye O. Injuries. N Engl J Med 2013; 368: 1723 30. 169
  10. Thomas KE, Stevens JA, Sarmiento K, Wald MM. Fall-related traumatic brain injury deaths and hospitalizations among older adults--United States, 2005. J Safety Res 2008; 39: 269 72. 181
  11. Kehoe A, Smith JE, Bouamra O, Edwards A, Yates D, Lecky F. Older patients with traumatic brain injury present with a higher GCS score than younger patients for a given severity of injury. Emerg Med J 2016; 33: 381 85. 209
  12. Fakhry SM, Trask AL, Waller MA, Watts DD, and the IRTC Neurotrauma Task Force. Management of brain-injured patients by an evidence-based medicine protocol improves outcomes and decreases hospital charges. J Trauma 2004; 56: 492 99, discussion 499 500. 217
  13. Bullock M, Chesnut R, Ghajar J. Guidelines for the Surgical management of Traumatic Brain Injury. Neurosurgery 2006; 58: S2 vi. 267
  14. Vitek MP, Brown CM, Colton CA. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 2009; 30: 1350 60. 310
  15. Lawrence DW, Comper P, Hutchison MG, Sharma B. T E -4 allele on outcome following traumatic brain injury: A systematic review. Brain Inj 2015; 29: 1018 31. 311
  16. Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients A Neurology 1995; 45: 555 57. 314
  17. by Taylor & Francis Group, LLC., 2015. 320
  18. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975; 1: 480 84. 346
  19. Lu J, Marmarou A, Lapane K, Turf E, Wilson L, and the IMPACT Group, and the American Brain Injury Consortium Study Participation Centers. A method for reducing misclassification in the extended Glasgow Outcome Score. J Neurotrauma 2010; 27: 843 52. 349
  20. Leening MJG, Vedder MM, Witteman JCM, Pencina MJ, Steyerberg EW. Net reclassification improvement: computation, Ann Intern Med 2014; 160: 122 31. 387
  21. Zemek R, Barrowman N, Freedman SB, et al, and the Pediatric Emergency Research Canada (PERC) Concussion Team. Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED. JAMA 2016; 315: 1014 25. 404 NINDS Common Data Elements. Traumatic Brain Injury. http://www.commondataelements.ninds.nih.gov/tbi.aspx#tab=Data_Standards (accessed March 15, 2017). 405
  22. Vickers AJ. " W Trials 2016; 17: 227. 417
  23. Varnai P, Rentel M, Simmonds P, Sharp T-A, Mostert B, de Jongh T. Assessing the research potential of access to clinical trial data. Final report to the Wellcome Trust. Brighton, 2015 https://wellcome.ac.uk/sites/default/files/assessing-research-potential-of- access-to-clinical-trials-data-wellcome-mar15.pdf. 418 OCR HIPAA Privacy. RESEARCH. 2003 https://www.hhs.gov/hipaa/for-professionals/special-topics/research/index.html (accessed March 15, 2017). 419 Official Journal of the European Union. Directive (EU) 2016/679 of the European Parliamant and of the Council of 27 April 2016. 2016 http://eur-lex.europa.eu/legal-content/en/TXT/?uri=CELEX%3A32016R0679 (accessed July 17, 2017). 420
  24. Johnson VE, Stewart W " DH W - humans. Brain Pathol 2012; 222: 142 9. 456
  25. US Preventive Services Task Force. Counseling About Proper Use of Motor Vehicle Occupant Restraints and Avoidance of Alcohol Use While Driving: Recommendation Statement. Am Fam Physician 2008; 78: 373に76. 462 European Commission. Safety in the automotive sector. https://ec.europa.eu/growth/sectors/automotive/safety_en (accessed May 6, 2017). 463
  26. Zemek R, Osmond MH, Barrowman N, et al. Predicting and Preventing Postconcussive Problems in Paediatrics (5P) study [published correction appears in BMJ Open. 2013;3(8):e003550corr1]. BMJ Open. 2013;3(8):1-10. 494
  27. Post A, Hoshizaki TB, Gilchrist MD, Koncan D, Dawson L, Chen W, Ledoux AA, Zemek R for the Pediatric Emergency Research Canada (PERC) 5P Concussion team. A comparison of history and no history of concussion groups by biomechanical reconstruction of a youth population. J Neurosurg Pediatr. 2017 Jan 27:19(4): 502-510. doi: 10.3171/2016.10.PEDS16449. 127 498 · DOI
  28. M C P M W D J C the 5th international conference on concussion in sport held in Berlin, October 2016. Br J Sports Med 2017;51:838-847. 526 The Berlin International Consensus Meeting on Concussion in Sport.
  29. Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC. Clinical presentation of chronic traumatic encephalopathy. Neurology 2013 Sep 24;81(13):1122-9. 538
  30. McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee HS, Kubilus CA, Stern RA. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009 Jul;68(7):709- 35. 539
  31. Diamond ML, Ritter AC, Failla MD, Boles JA, Conley YP, Kochanek PM, Wagner AK. IL- epilepsy development: a genetics and biomarker cohort study. Epilepsia 2014 Jul;55(7):1109-19. 543
  32. Gupta D, Sharma D, Kannan N, Prapruettham S, Mock C, Wang J, Qiu Q, Pandey RM, Mahapatra A, Dash HH, Hecker JG, Rivara FP, Rowhani-Rahbar A, Vavilala MS. Guideline Adherence and Outcomes in Severe Adult Traumatic Brain Injury for the CHIRAG (Collaborative Head Injury and Guidelines) Study. World Neurosurg 2016 May;89:169-79. Series paper references (should be refs 17 :
  33. Wilson LW, Stewart W, Dams-O C K T Lancet Neurol 2017 (in press). [Need to update citation details]

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Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., Citerio, G., Coburn, M., Cooper, D. J., Crowder, A. T., Czeiter, E., Czosnyka, M., Diaz-Arrastia, R., Dreier, J. P., Duhaime, A.-C., Ercole, A., van Essen, T. A., Feigin, V. L., Gao, G., Giacino, J., Gonzalez-Lara, L. E., Gruen, R. L., Gupta, D., Hartings, J. A., Hill, S., Jiang, J.-Y., Ketharanathan, N., Kompanje, E. J. O., Lanyon, L., Laureys, S., Lecky, F., Levin, H., Lingsma, H. F., Maegele, M., Majdan, M., Manley, G., Marsteller, J., Mascia, L., McFadyen, C., Mondello, S., Newcombe, V., Palotie, A., Parizel, P. M., Peul, W., Piercy, J., Polinder, S., Puybasset, L., Rasmussen, T. E., Rossaint, R., Smielewski, P., Söderberg, J., Stanworth, S. J., Stein, M. B., von Steinbüchel, N., Stewart, W., Steyerberg, E. W., Stocchetti, N., Synnot, A., Te Ao, B., Tenovuo, O., Theadom, A., Tibboel, D., Videtta, W., Wang, K. K. W., Williams, W. H., Wilson, L., Yaffe, K., Adams, H., Agnoletti, V., Allanson, J., Amrein, K., Andaluz, N., Anke, A., Antoni, A., van As, A. B., Audibert, G., Azaševac, A., Azouvi, P., Azzolini, M. L., Baciu, C., Badenes, R., Barlow, K. M., Bartels, R., Bauerfeind, U., Beauchamp, M., Beer, D., Beer, R., Belda, F. J., Bellander, B.-M., Bellier, R., Benali, H., Benard, T., Beqiri, V., Beretta, L., Bernard, F., Bertolini, G., Bilotta, F., Blaabjerg, M., den Boogert, H., Boutis, K., Bouzat, P., Brooks, B., Brorsson, C., Bullinger, M., Burns, E., Calappi, E., Cameron, P., Carise, E., Castaño-León, A. M., Causin, F., Chevallard, G., Chieregato, A., Christie, B., Cnossen, M., Coles, J., Collett, J., Della Corte, F., Craig, W., Csato, G., Csomos, A., Curry, N., Dahyot-Fizelier, C., Dawes, H., DeMatteo, C., Depreitere, B., Dewey, D., van Dijck, J., Đilvesi, Đ., Dippel, D., Dizdarevic, K., Donoghue, E., Duek, O., Dulière, G.-L., Dzeko, A., Eapen, G., Emery, C. A., English, S., Esser, P., Ezer, E., Fabricius, M., Feng, J., Fergusson, D., Figaji, A., Fleming, J., Foks, K., Francony, G., Freedman, S., Freo, U., Frisvold, S. K., Gagnon, I., Galanaud, D., Gantner, D., Giraud, B., Glocker, B., Golubovic, J., Gómez López, P. A., Gordon, W. A., Gradisek, P., Gravel, J., Griesdale, D., Grossi, F., Haagsma, J. A., Håberg, A. K., Haitsma, I., Van Hecke, W., Helbok, R., Helseth, E., van Heugten, C., Hoedemaekers, C., Höfer, S., Horton, L., Hui, J., Huijben, J. A., Hutchinson, P. J., Jacobs, B., van der Jagt, M., Jankowski, S., Janssens, K., Jelaca, B., Jones, K. M., Kamnitsas, K., Kaps, R., Karan, M., Katila, A., Kaukonen, K.-M., De Keyser, V., Kivisaari, R., Kolias, A. G., Kolumbán, B., Kolundžija, K., Kondziella, D., Koskinen, L.-O., Kovács, N., Kramer, A., Kutsogiannis, D., Kyprianou, T., Lagares, A., Lamontagne, F., Latini, R., Lauzier, F., Lazar, I., Ledig, C., Lefering, R., Legrand, V., Levi, L., Lightfoot, R., Lozano, A., MacDonald, S., Major, S., Manara, A., Manhes, P., Maréchal, H., Martino, C., Masala, A., Masson, S., Mattern, J., McFadyen, B., McMahon, C., Meade, M., Melegh, B., Menovsky, T., Moore, L., Morgado Correia, M., Morganti-Kossmann, M. C., Muehlan, H., Mukherjee, P., Murray, L., van der Naalt, J., Negru, A., Nelson, D., Nieboer, D., Noirhomme, Q., Nyirádi, J., Oddo, M., Okonkwo, D. O., Oldenbeuving, A. W., Ortolano, F., Osmond, M., Payen, J.-F., Perlbarg, V., Persona, P., Pichon, N., Piippo-Karjalainen, A., Pili-Floury, S., Pirinen, M., Ple, H., Poca, M. A., Posti, J., Van Praag, D., Ptito, A., Radoi, A., Ragauskas, A., Raj, R., Real, R. G. L., Reed, N., Rhodes, J., Robertson, C., Rocka, S., Røe, C., Røise, O., Roks, G., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossi, S., Rueckert, D., de Ruiter, G. C. W., Sacchi, M., Sahakian, B. J., Sahuquillo, J., Sakowitz, O., Salvato, G., Sánchez-Porras, R., Sándor, J., Sangha, G., Schäfer, N., Schmidt, S., Schneider, K. J., Schnyer, D., Schöhl, H., Schoonman, G. G., Schou, R. F., Sir, Ö., Skandsen, T., Smeets, D., Sorinola, A., Stamatakis, E., Stevanovic, A., Stevens, R. D., Sundström, N., Taccone, F. S., Takala, R., Tanskanen, P., Taylor, M. S., Telgmann, R., Temkin, N., Teodorani, G., Thomas, M., Tolias, C. M., Trapani, T., Turgeon, A., Vajkoczy, P., Valadka, A. B., Valeinis, E., Vallance, S., Vámos, Z., Vargiolu, A., Vega, E., Verheyden, J., Vik, A., Vilcinis, R., Vleggeert-Lankamp, C., Vogt, L., Volovici, V., Voormolen, D. C., Vulekovic, P., Vande Vyvere, T., Van Waesberghe, J., Wessels, L., Wildschut, E., Williams, G., Winkler, M. K. L., Wolf, S., Wood, G., Xirouchaki, N., Younsi, A., Zaaroor, M., Zelinkova, V., Zemek, R., & Zumbo, F.
Affiliations
  • University of Antwerp (BE)
  • University of Cambridge (GB)
  • Barrow Neurological Institute (US)
  • NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
  • Monash University (AU)
  • University of California San Diego (US)
  • University of Washington (US)
  • Azienda Ospedaliera San Gerardo (IT)
  • Universitätsklinikum Aachen (DE)
  • University of Pecs (HU)
  • University of Pennsylvania (US)
  • Charité – Universitätsmedizin Berlin (DE)
  • Harvard University (US)
  • Shanghai Jiao Tong University (CN)
  • Nanyang Technological University (SG)
  • All India Institute of Medical Sciences (IN)
  • University of Cincinnati (US)
  • École Polytechnique Fédérale de Lausanne (CH)
  • Auckland University of Technology (NZ)
  • Karolinska Institutet (SE)
  • University of Liège (BE)
  • University of Sheffield (GB)
  • Baylor College of Medicine (US)
  • Erasmus MC (NL)
  • Witten/Herdecke University (DE)
  • University of California, San Francisco (US)
  • Johns Hopkins University (US)
  • Sapienza University of Rome (IT)
  • University of Messina (IT)
  • Leiden University Medical Center (NL)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • John Radcliffe Hospital (GB)
  • University of Milan (IT)
  • La Trobe University (AU)
  • Hospital Posadas (AR)
  • University of Florida (US)
  • University of Stirling (GB)
Corresponding author
  • Maas, Andrew I R
  • Menon, David K
ORCID
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2017-12
Volume
16
Issue
12
Pages
987-1048
ISSN
1474-4422 (ISSN-L)
DOI
10.1016/s1474-4422(17)30371-x
OpenAlex
W2767813783
Cited by
2,609
References
514
Citations by year
2026: 314 · 2025: 358 · 2024: 329 · 2023: 368 · 2022: 350 · 2021: 313 · 2020: 276 · 2019: 209 · 2018: 82 · 2017: 2 · 2013: 1 · 2012: 1
FWCI
20.63
Type
journal article
Language
en
Open access
Licence
Locations
  • The Lancet Neurology (acceptedVersion, other-oa)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by-nc-nd)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
  • Stirling Online Research Repository (University of Stirling) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion, other-oa)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
  • IRIS (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
  • AIRUS (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
  • Apollo
Funders
  • US Department of Defense
  • CIHR
  • GlaxoSmithKline
  • Canadian Institutes of Health Research
  • European Commission
  • US National Institutes of Health-National Institute of Neurological Disorders and Stroke
  • One Mind
  • Fonds de recherche du Québec Santé
  • Hotchkiss Brain Institute
  • Ontario Brain Institute
  • Ontario Neurotrauma Foundation
  • Hannelore Kohl Stiftung, Germany
  • UK National Institute for Health Research
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords
traumatic brain injury, TBI prevention, clinical care, global health burden, disability, low- and middle-income countries, research priorities, health policy recommendations
MeSH terms
Brain Injuries, Traumatic, Brain Injuries, Humans

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