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Cited by 464

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Herpes simplex virus encephalitis is a trigger of brain autoimmunity

Open access
Armangue, Thaís, Leypoldt, Frank, Málaga, Ignacio, Raspall‐Chaure, Miquel, Marti, Itxaso, Nichter, Charles, Pugh, John, Vicente‐Rasoamalala, Monica, Lafuente‐Hidalgo, Miguel, Macaya, Alfons, Ke, Michael, Titulaer, Maarten J., Höftberger, Romana, Sheriff, Heather, Glaser, Carol, Dalmau, Josep·2014·Annals of Neurology

Abstract

In 5 prospectively diagnosed patients with relapsing post–herpes simplex encephalitis (HSE), N‐methyl‐D‐aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p = 0.004; cerebrospinal fluid, p = 0.04). The 3 retrospectively identified NMDAR antibody–positive patients also had evidence of relapsing post‐HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity. Ann Neurol 2014;75:317–323

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Metadata

Authors
Armangue, T., Leypoldt, F., Málaga, I., Raspall‐Chaure, M., Marti, I., Nichter, C., Pugh, J., Vicente‐Rasoamalala, M., Lafuente‐Hidalgo, M., Macaya, A., Ke, M., Titulaer, M. J., Höftberger, R., Sheriff, H., Glaser, C., & Dalmau, J.
Venue
Annals of Neurology
Publisher
Wiley
Published
2014-02
Volume
75
Issue
2
Pages
317-323
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2108987556
Cited by
464
References
4
FWCI
21.85
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Herpes simplex virus encephalitis is a trigger of brain autoimmunity. https://app.cochat.ai/papers/10.1002/ana.24083
The paper
Armangue, T., Leypoldt, F., Málaga, I., Raspall‐Chaure, M., Marti, I., Nichter, C., Pugh, J., Vicente‐Rasoamalala, M., Lafuente‐Hidalgo, M., Macaya, A., Ke, M., Titulaer, M. J., Höftberger, R., Sheriff, H., Glaser, C., & Dalmau, J. (2014). Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Annals of Neurology. https://doi.org/10.1002/ana.24083

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.