The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Autoantibodies in neurological disease
Open accessAbstract
The realization that autoantibodies can contribute to dysfunction of the brain has brought about a paradigm shift in neurological diseases over the past decade, offering up important novel diagnostic and therapeutic opportunities. Detection of specific autoantibodies to neuronal or glial targets has resulted in a better understanding of central nervous system autoimmunity and in the reclassification of some diseases previously thought to result from infectious, ‘idiopathic’ or psychogenic causes. The most prominent examples, such as aquaporin 4 autoantibodies in neuromyelitis optica or NMDAR autoantibodies in encephalitis, have stimulated an entire field of clinical and experimental studies on disease mechanisms and immunological abnormalities. Also, these findings inspired the search for additional autoantibodies, which has been very successful to date and has not yet reached its peak. This Review summarizes this rapid development at a point in time where preclinical studies have started delivering fundamental new data for mechanistic understanding, where new technologies are being introduced into this field, and — most importantly — where the first specifically tailored immunotherapeutic approaches are emerging. Here, Harald Prüss discusses how autoantibodies can contribute to neurological diseases. The identification of specific autoantibodies to neuronal and glial targets has increased our understanding of autoimmunity in the central nervous system and led to the reclassification of some diseases previously thought to result from infection or ‘idiopathic’ causes.
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1 retracted
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Self-citationAlzheimer Disease: An Update on Pathobiology and Treatment Strategies
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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
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B cells drive neuropathic pain–related behaviors in mice through IgG–Fc gamma receptor signaling
Lacagnina, M. J., Willcox, K. F., Boukelmoune, N., Bavencoffe, A., Sankaranarayanan, I., Barratt, D. T., Zuberi, Y. A., Dayani, D., Chavez, M. V., Lu, J. T., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj1277 · Cited by 60
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities
Bünger, I., Talucci, I., Kreye, J., Höltje, M., Makridis, K. L., Foverskov Rasmussen, H., van Hoof, S., Cordero-Gomez, C., Ullrich, T., Sedlin, E., et al. (2023) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2023.100678 · Cited by 5
Self-citation
Metadata
- Authors
- Prüss, H.
- Venue
- Nature Reviews Immunology
- Published
- 2021-05-11
- Volume
- 21
- Issue
- 12
- Pages
- 798-813
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W3160102114
- Cited by
- 319
- References
- 190
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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