Near‐infrared light is neuroprotective in a monkey model of P arkinson disease
Open accessAbstract
Objective: To examine whether near‐infrared light (NIr) treatment reduces clinical signs and/or offers neuroprotection in a subacute 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) monkey model of Parkinson disease. Methods: We implanted an optical fiber device that delivered NIr (670nm) to the midbrain of macaque monkeys, close to the substantia nigra of both sides. MPTP injections (1.5–2.1mg/kg) were made over a 5‐ to 7‐day period, during which time the NIr device was turned on. This was then followed by a 3‐week survival period. Monkeys were evaluated clinically (eg, posture, bradykinesia) and behaviorally (open field test), and their brains were processed for immunohistochemistry and stereology. Results: All monkeys in the MPTP group developed severe clinical and behavioral impairment (mean clinical scores = 21–34; n = 11). By contrast, the MPTP‐NIr group developed much less clinical and behavioral impairment (n = 9); some monkeys developed moderate clinical signs (mean scores = 11–15; n = 3), whereas the majority—quite remarkably—developed few clinical signs (mean scores = 1–6; n = 6). The monkeys that developed moderate clinical signs had hematic fluid in their optical fibers at postmortem, presumably limiting NIr exposure and overall clinical improvement. NIr was not toxic to brain tissue and offered neuroprotection to dopaminergic cells and their terminations against MPTP insult, particularly in animals that developed few clinical signs. Interpretation: Our findings indicate NIr to be an effective therapeutic agent in a primate model of the disease and create the template for translation into clinical trials. ANN NEUROL 2016;79:59–75
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Wraparound peripheral nerve interfaces can reduce foreign body reactions caused by insertion.
“The wraparound peripheral nerve interface can reduce foreign body reactions caused by insertion.[58,302,551,554]”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [554]
The Surgical Procedure and Optical Fiber Implant Sites in Midbrain sections describe an optical fiber inserted into monkeys’ midbrains, not a wraparound peripheral nerve interface. The No Sign of Toxicity in the Brain by NIr section reports mechanical damage and gliosis along the fiber tract, but does not test whether a wraparound design reduces insertion-related foreign-body reactions. Searches for wraparound and peripheral nerve interfaces found no passage addressing that comparison; page numbers were not provided in our copy. (LLM, conf=0.76)
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- Authors
- Darlot, F., Moro, C., El Massri, N., Chabrol, C., Johnstone, D. M., Reinhart, F., Agay, D., Torres, N., Bekha, D., Auboiroux, V., Costecalde, T., Peoples, C. L., Anastascio, H. D. T., Shaw, V. E., Stone, J., Mitrofanis, J., & Benabid, A.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Departments of Anatomy University of Sydney Sydney New South Wales Australia
- The University of Sydney (AU)
- University Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus Grenoble France
- Corresponding author
- Mitrofanis, John
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2015-12-12
- Volume
- 79
- Issue
- 1
- Pages
- 59-75
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1946919574
- Semantic Scholar
- ba58b5cfd5da3670ae46ed5854a0d70139efc482
- Cited by
- 114
- References
- 49
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 8 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 9
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sir Zelman Cowen Universities Fund
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- near-infrared phototherapy, Parkinson's disease, neuroprotection, MPTP, substantia nigra, dopaminergic neurons, bradykinesia, low-level laser therapy
- MeSH terms
- Animals, Behavior, Animal, Disease Models, Animal, Infrared Rays, Macaca fascicularis, Male, Mesencephalon, Neurotoxins, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP Poisoning, Low-Level Light Therapy, Optical Fibers
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