[F‐18]AV‐1451 positron emission tomography retention in choroid plexus: More than “off‐target” binding
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Off-target binding cannot fully account for [18F]AV-1451 signal in the striatum or cortex, nor in the choroid plexus.
“However, ‘off-target’ binding can neither fully account for [18F]AV-1451 signal in striatum or cortex – as previous post mortem analyses reveal that no neuromelanin accumulates there8,33 – nor in choroid plexus as histological analysis revealed tangle-like inclusions in its epithelial cells34.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [34]
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- Authors
- Ikonomovic, M. D., Abrahamson, E. E., Price, J. C., Mathis, C. A., & Klunk, W. E.
- Affiliations
- Departments of Neurology University of Pittsburgh VA Pittsburgh HS Pittsburgh PA
- University of Pittsburgh (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2016-07-07
- Volume
- 80
- Issue
- 2
- Pages
- 307-308
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC4982815
- OpenAlex
- W2466842601
- Cited by
- 81
- References
- 4
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 10 · 2018: 13 · 2017: 9 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P01 AG025204, P01 AG14449)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- positron emission tomography, choroid plexus, off-target binding, radiotracer retention, neuroimaging
- MeSH terms
- Carbolines, Choroid Plexus, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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