The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies
Open accessAbstract
Objective: Blunted tachycardia during hypotension is a characteristic feature of patients with autonomic failure, but the range has not been defined. This study reports the range of orthostatic heart rate (HR) changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Methods: Patients evaluated at sites of the U.S. Autonomic Consortium (NCT01799915) underwent standardized autonomic function tests and full neurological evaluation. Results: We identified 402 patients with orthostatic hypotension (OH) who had normal sinus rhythm. Of these, 378 had impaired sympathetic activation (ie, neurogenic OH) and based on their neurological examination were diagnosed with Parkinson disease, dementia with Lewy bodies, pure autonomic failure, or multiple system atrophy. The remaining 24 patients had preserved sympathetic activation and their OH was classified as nonneurogenic, due to volume depletion, anemia, or polypharmacy. Patients with neurogenic OH had twice the fall in systolic blood pressure (SBP; −44 ± 25 vs −21 ± 14 mmHg [mean ± standard deviation], p < 0.0001) but only one‐third of the increase in HR of those with nonneurogenic OH (8 ± 8 vs 25 ± 11 beats per minute [bpm], p < 0.0001). A ΔHR/ΔSBP ratio of 0.492 bpm/mmHg had excellent sensitivity (91.3%) and specificity (88.4%) to distinguish between patients with neurogenic from nonneurogenic OH (area under the curve = 0.96, p < 0.0001). Within patients with neurogenic OH, HR increased more in those with multiple system atrophy (p = 0.0003), but there was considerable overlap with patients with Lewy body disorders. Interpretation: A blunted HR increase during hypotension suggests a neurogenic cause. A ΔHR/ΔSBP ratio < 0.5 bpm/mmHg is diagnostic of neurogenic OH. Ann Neurol 2018;83:522–531
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Cites
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289
Second consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140
Self-citationFreeman, R., Wieling, W., Axelrod, F. B., Benditt, D. G., Benarroch, E., Biaggioni, I., Cheshire, W. P., Chelimsky, T., Cortelli, P., Gibbons, C. H., et al. (2011) · Clinical Autonomic Research · doi:10.1007/s10286-011-0119-5 · Cited by 1,697 · cited 3×
“Neither the first nor the second OH consensus criteria defined HR ranges.(1,5) A recent consensus panel proposed an increase in HR of <15 beats per minute (bpm) to support the diagnosis of neurogenic OH, but this proposed range was based on experts’ clinical experience rather than scientific evidence.”
BackgroundSelf-citationFreeman, R., Wieling, W., Axelrod, F. B., Benditt, D. G., Benarroch, E., Biaggioni, I., Cheshire, W. P., Chelimsky, T., Cortelli, P., Gibbons, C. H., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.02.004 · Cited by 1,243
Self-citationNeurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384
Self-citationNeuropathology of multiple system atrophy: New thoughts about pathogenesis
Jellinger, K. A. (2014) · Movement Disorders · doi:10.1002/mds.26052 · Cited by 181
Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
Vogel, E. R., Sandroni, P., & Low, P. A. (2005) · Neurology · doi:10.1212/01.wnl.0000184504.13173.ef · Cited by 160
Self-citationIs cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study
Palma, J., Carmona‐Abellan, M., Barriobero, N., Trevino-Peinado, C., Garcia‐Lopez, M., Fernandez‐Jarne, E., & Luquin, M. R. (2013) · Movement Disorders · doi:10.1002/mds.25431 · Cited by 77
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The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy
Wenning, G. K., Stankovic, I., Vignatelli, L., Fanciulli, A., Calandra‐Buonaura, G., Seppi, K., Palma, J., Meissner, W. G., Krismer, F., Berg, D., et al. (2022) · Movement Disorders · doi:10.1002/mds.29005 · Cited by 833
Self-citationA biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria
Höglinger, G. U., Adler, C. H., Berg, D., Klein, C., Outeiro, T. F., Poewe, W., Postuma, R., Stoessl, A. J., & Lang, A. E. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00404-0 · Cited by 549
Kaufmann, H., Norcliffe-Kaufmann, L., & Palma, J.-A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1509723 · Cited by 265
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Metadata
- Authors
- Norcliffe‐Kaufmann, L., Kaufmann, H., Palma, J., Shibao, C. A., Biaggioni, I., Peltier, A. C., Singer, W., Low, P. A., Goldstein, D. S., Gibbons, C. H., Freeman, R., Robertson, D., & Autonomic Disorders Consortium
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 83
- Issue
- 3
- Pages
- 522-531
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2789300638
- Cited by
- 242
- References
- 8
- FWCI
- 18.62
- Type
- journal article
- Language
- en
- Open access
- green
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