Cited by 384Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlVestibular and auditory disorders

Neurogenic Orthostatic Hypotension

Freeman, Roy·2008·New England Journal of Medicine

Abstract

A 65-year-old man reports a 6-month history of dizziness, light-headedness, weakness, and fatigue while upright. He takes no medication and has no personal or family history of neurologic disease. On physical examination, his supine blood pressure is 160/100 mm Hg, with a heart rate of 72 beats per minute; on standing, his blood pressure falls to 70/40 mm Hg, with no change in heart rate. The results of the remainder of the examination, including neurologic examination, are normal. How should he be evaluated and treated?

Integrity signals

Registry

Crossref · 10.1056/nejmcp074189

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55 of 55 references verified0 citation errors · 0 not checkable

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  • The most common paraneoplastic antibodies are anti-Hu, while others are anti-Purkinje cell cytoplasmic autoantibody type 2 and anti-collapsin response mediator protein 5.

    “The most common paraneoplastic antibodies are anti-Hu, while others are anti-Purkinje cell cytoplasmic autoantibody type 2 and anti-collapsin response mediator protein 5.”

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Authors
Freeman, R.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Freeman, Roy
Venue
New England Journal of Medicine
Published
2008-02-07
Volume
358
Issue
6
Pages
615-624
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2137626905
Cited by
384
References
55
Citations by year
2026: 12 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 24 · 2019: 21 · 2018: 30 · 2017: 19 · 2016: 24 · 2015: 31 · 2014: 21 · 2013: 21 · 2012: 14
FWCI
3.98
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
neurogenic orthostatic hypotension, autonomic dysfunction, orthostatic hypotension, dizziness, blood pressure, treatment
MeSH terms
Aged, Amyloidosis, Autonomic Nervous System Diseases, Diagnosis, Differential, Humans, Hypotension, Orthostatic, Male, Medical History Taking, Sjogren's Syndrome, Baroreflex, Syncope, Vasovagal, Amyloid Neuropathies, Familial

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