Neurogenic Orthostatic Hypotension
Abstract
A 65-year-old man reports a 6-month history of dizziness, light-headedness, weakness, and fatigue while upright. He takes no medication and has no personal or family history of neurologic disease. On physical examination, his supine blood pressure is 160/100 mm Hg, with a heart rate of 72 beats per minute; on standing, his blood pressure falls to 70/40 mm Hg, with no change in heart rate. The results of the remainder of the examination, including neurologic examination, are normal. How should he be evaluated and treated?
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The most common paraneoplastic antibodies are anti-Hu, while others are anti-Purkinje cell cytoplasmic autoantibody type 2 and anti-collapsin response mediator protein 5.
“The most common paraneoplastic antibodies are anti-Hu, while others are anti-Purkinje cell cytoplasmic autoantibody type 2 and anti-collapsin response mediator protein 5.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [431]
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- Authors
- Freeman, R.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Freeman, Roy
- ORCID
- Freeman, Roy
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2008-02-07
- Volume
- 358
- Issue
- 6
- Pages
- 615-624
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2137626905
- Cited by
- 384
- References
- 55
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 24 · 2019: 21 · 2018: 30 · 2017: 19 · 2016: 24 · 2015: 31 · 2014: 21 · 2013: 21 · 2012: 14
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- neurogenic orthostatic hypotension, autonomic dysfunction, orthostatic hypotension, dizziness, blood pressure, treatment
- MeSH terms
- Aged, Amyloidosis, Autonomic Nervous System Diseases, Diagnosis, Differential, Humans, Hypotension, Orthostatic, Male, Medical History Taking, Sjogren's Syndrome, Baroreflex, Syncope, Vasovagal, Amyloid Neuropathies, Familial
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