The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Computerized densitometry and color coding of [14C] deoxyglucose autoradiographs
Open accessAbstract
A computerized image processing system has been developed for quantitative analyses of autoradiographs obtained with the [14 C] deoxyglucose method. The system is composed of standard, commercially available components and includes a scanning microdensitometer, computer, image memory and display system, and monochrome and color monitors. The associated computer programs are written in PASCAL. Autoradiographs are automatically scanned, and the optical density of each spot is digitized at a maximum resolution of 65,536 readings per 6.4 X 6.4 mm area and stored in memory. Images can be reconstructed from the data in memory, displayed on the monitors, and utilized for microdensitometric analyses or manipulated for image enhancement, enlargement, or weighted averaging of selected regions. The digitized data can also be utilized to solve the operational equation of the [14 C] deoxyglucose method, and color‐coded images of autoradiographs can be reconstructed so that each color represents a narrow range of the rate of glucose utilization. By means of this system, it is possible to generate quantitative metabolic maps that display the distribution of actual rates of local glucose utilization throughout the entire central nervous system in regions as small as 100 μm or less.
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Cites
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Self-citation(1982) · Elsevier eBooks · doi:10.1016/c2009-0-21955-6 · Cited by 4,596
The [18F]fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man.
Reivich, M., Kuhl, D., Wolf, A., Greenberg, J., Phelps, M., Ido, T., Casella, V, Fowler, J., Hoffman, E., Alavi, A., et al. (1979) · Circulation Research · doi:10.1161/01.res.44.1.127 · Cited by 1,220
Self-citationHartl, P. (1976) · Ecological Studies · doi:10.1007/978-3-642-66236-2_9 · Cited by 1,213
Hawkes, P. W. (1978) · Nature · doi:10.1038/272740a0 · Cited by 827
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb03919.x · Cited by 807
Self-citationLassen, N. A., Ingvar, D. H., & Skinhøj, E. (1978) · Scientific American · doi:10.1038/scientificamerican1078-62 · Cited by 637
Kennedy, C., Des Rosiers, M. H., Sakurada, O., Shinohara, M., Reivich, M., Jehle, J. W., & Sokoloff, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4230 · Cited by 306
Self-citationLocal cerebral glucose utilization in the normal conscious macaque monkey
Kennedy, C., Sakurada, O., Shinohara, M., Jehle, J., & Sokoloff, L. (1978) · Annals of Neurology · doi:10.1002/ana.410040402 · Cited by 246
Self-citationMetabolic Anatomy of Focal Motor Seizures
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Sokoloff, L. (1981) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1981.4 · Cited by 580
Self-citationHill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413
Curtis, C., Gamez, J. E., Singh, U., Sadowsky, C. H., Villena, T., Sabbagh, M. N., Beach, T. G., Duara, R., Fleisher, A. S., Frey, K. A., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4144 · Cited by 332
Everson, C., Smith, C., & Sokoloff, L. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-11-06769.1994 · Cited by 96
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Metadata
- Authors
- Goochee, C., Rasband, W., & Sokoloff, L.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1980-04
- Volume
- 7
- Issue
- 4
- Pages
- 359-370
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2051094114
- Cited by
- 344
- References
- 14
- FWCI
- 28.00
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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