Cited by 180Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

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Dopaminergic dysfunction in tourette syndrome

Singer, Harvey S., Butler, Ian J., Tune, Larry E., Seifert, William E., Coyle, Joseph T.·1982·Annals of Neurology

DOI 10.1002/ana.410120408

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Abstract

A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome. Pretteatment cerebrospinal fluid levels of homovanillic acid (CSF HV A) were significantly reduced in all patients, whereas 5‐hydroxyindoleacetic acid was reduced in only two. With haloperidol treatment, symptoms decreased in all cases (21 to 88%) and clinical improvement was associated withan increased level of CSF HV A, often returning to the normal range. Optimal therapeutic response was found with serum levels of haloperidol between 1 and 4 ng/ml; however, disturbing side effects also occurred within this range. These results support the hypothesis that Tourette syndrome may result form a supersensitivity of dopaminergic receptors.

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Authors: Singer, H. S., Butler, I. J., Tune, L. E., Seifert, W. E., & Coyle, J. T.
Affiliations: Johns Hopkins University (US)
United States Public Health Service (US)
Corresponding author: Singer, Harvey S.
ORCID: Singer, Harvey S.
Coyle, Joseph T.
Venue: Annals of Neurology
Publisher: Wiley
Published: 1982-10
Volume: 12
Issue: 4
Pages: 361-366
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.410120408
OpenAlex: W2011897114
Cited by: 180
References: 28
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2013: 3 · 2012: 7
FWCI: 8.36
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8042 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: Tourette syndrome, haloperidol, dopaminergic dysfunction, homovanillic acid, cerebrospinal fluid, 5-hydroxyindoleacetic acid, antipsychotic treatment response, adverse drug reactions
MeSH terms: Adolescent, Dopamine, Female, Tourette Syndrome, Haloperidol, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Male, Methoxyhydroxyphenylglycol, Nervous System Diseases

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