The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Dopaminergic dysfunction in tourette syndrome
Abstract
A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome. Pretteatment cerebrospinal fluid levels of homovanillic acid (CSF HV A) were significantly reduced in all patients, whereas 5‐hydroxyindoleacetic acid was reduced in only two. With haloperidol treatment, symptoms decreased in all cases (21 to 88%) and clinical improvement was associated withan increased level of CSF HV A, often returning to the normal range. Optimal therapeutic response was found with serum levels of haloperidol between 1 and 4 ng/ml; however, disturbing side effects also occurred within this range. These results support the hypothesis that Tourette syndrome may result form a supersensitivity of dopaminergic receptors.
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“The DA hypothesis of TS was originally proposed nearly 30 years ago [617], and has been corroborated by post-mortem data [618]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [617]
Citations
Cites
Antischizophrenic Drugs and Brain Cholinergic Receptors
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Biogenic amine metabolism in tourette syndrome
Butler, I. J., Koslow, S. H., Seifert, W. E., Caprioli, R. M., & Singer, H. S. (1979) · Annals of Neurology · doi:10.1002/ana.410060109 · Cited by 185
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Cited by
Sorted by citations
Tourette syndrome, associated conditions and the complexities of treatment
Robertson, M. M. (2000) · Brain · doi:10.1093/brain/123.3.425 · Cited by 704
Beyond eye gaze: What else can eyetracking reveal about cognition and cognitive development?
Eckstein, M. K., Guerra-Carrillo, B., Singley, A. T. M., & Bunge, S. A. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.11.001 · Cited by 765
Treatment of ADHD in children with tics: A randomized controlled trial
The Tourette’s Syndrome Study Group (2002) · Neurology · doi:10.1212/wnl.58.4.527 · Cited by 504
Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus
Visser-Vandewalle, V. E. R. M., van der Linden, C., Groenewegen, H. J., & Caemaert, J. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05964-9 · Cited by 427
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Singer, H. S. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)01012-4 · Cited by 309
Self-citation
Metadata
- Authors
- Singer, H. S., Butler, I. J., Tune, L. E., Seifert, W. E., & Coyle, J. T.
- Affiliations
- Johns Hopkins University (US)
- United States Public Health Service (US)
- Corresponding author
- Singer, Harvey S.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1982-10
- Volume
- 12
- Issue
- 4
- Pages
- 361-366
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2011897114
- Cited by
- 180
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 4 · 2013: 3 · 2012: 7
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, haloperidol, dopaminergic dysfunction, homovanillic acid, cerebrospinal fluid, 5-hydroxyindoleacetic acid, antipsychotic treatment response, adverse drug reactions
- MeSH terms
- Adolescent, Dopamine, Female, Tourette Syndrome, Haloperidol, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Male, Methoxyhydroxyphenylglycol, Nervous System Diseases
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