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PET scan investigations of Huntington's disease: Cerebral metabolic correlates of neurological features and functional decline
Abstract
Fifteen drug‐free patients with early to midstage Huntington's disease were evaluated with quantitative neurological examinations, scales for functional capacity, computed tomographic (CT) scans, and positron emission tomographic (PET) scans of 18 F‐2‐fluoro‐2‐deoxyglucose (18 F‐FDG) uptake. All patients had abnormal indices of caudate metabolism on PET scanning, whereas in patients with early disease indices of putamen metabolism and CT measures of caudate atrophy were normal. Indices of caudate metabolism correlated highly with the patients' overall functional capacity (r = 0.906; p < 0.001) and bradykinesia/rigidity (r = −0.692; p < 0.01). Indices of putamen metabolism correlated highly with motor functions: Chorea (r = −0.841; p < 0.01), oculomotor abnormalities (r = −0.849; p < 0.01), and fine motor coordination (r = −0.866; p < 0.01). Indices of thalamic metabolism correlated positively with dystonia (r = 0.559; p < 0.05). The data suggest that PET scanning with 18 F‐FDG is a sensitive measure of brain dysfunction in Huntington's disease and that basal ganglia metabolism is highly correlated with the overall functional capacity of individual patients and with the degree of their motor abnormalities.
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Positron emission tomography with [18F]-fluorodeoxyglucose reveals a regional decrease of glucose usage in the striatum and cortex of persons symptomatic and at risk for HD.
“Positron emission tomography brain imaging with [18 F]-fluorodeoxyglucose has revealed a regional decrease of glucose usage in the striatum (caudate and putamen) and cortex (frontal and temporal lobes) of persons symptomatic and at risk for HD [3-8].”
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Cites
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A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266
Microglial activation correlates with severity in Huntington disease: A clinical and PET study
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NEUROIMAGING AND NEUROPSYCHOLOGY OF THE STRIATUM
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Metadata
- Authors
- Young, A. B., Penney, J. B., Starosta‐Rubinstein, S., Markel, D. S., Berent, S., Giordani, B., Ehrenkaufer, R., Jewett, D., & Hichwa, R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1986-09
- Volume
- 20
- Issue
- 3
- Pages
- 296-303
- ISSN
- 0364-5134
- 1531-8249
- Cited by
- 218
- References
- 1
- Language
- en
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