The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema
Abstract
Oxygen‐derived free radicals and membrane lipid peroxidation have been postulated to be involved in brain edema and cell death, secondary to ischemia and traumatic injury. Using a model of brain edema induced by cold‐induced injury, we have demonstrated an early elevation of superoxide radicals followed by permeability changes in the blood‐‐brain barrier and development of edema in injured brain. Intravenous injection of liposome‐entrapped copper‐zinc‐‐superoxide dismutase 5 minutes before the injury‐enhanced entry of the enzyme into endothelial cells of the blood‐‐brain barrier of injured brain reduced the brain level of superoxide radicals and ameliorated blood‐‐brain barrier permeability changes and brain edema. Identical treatment 5 minutes after injury was also effective. These data demonstrate that superoxide radicals play an important role in the delayed development of vasogenic brain edema following brain injury.
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Citations
Cites
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399
Cited by
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Dugan, L., Sensi, S., Canzoniero, L., Handran, S., Rothman, S., Lin, T., Goldberg, M., & Choi, D. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06377.1995 · Cited by 772
Oxygen radical mechanisms of brain injury following ischemia and reperfusion
Traystman, R. J., Kirsch, J. R., & Koehler, R. C. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1185 · Cited by 653
Kochanek, P. M., & Hallenbeck, J. M. (1992) · Stroke · doi:10.1161/01.str.23.9.1367 · Cited by 615
Yang, G., Chan, P. H., Chen, J., Carlson, E., Chen, S. F., Weinstein, P., Epstein, C. J., & Kamii, H. (1994) · Stroke · doi:10.1161/01.str.25.1.165 · Cited by 567
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Metadata
- Authors
- Chan, P. H., Longar, S., & Fishman, R. A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1987-06
- Volume
- 21
- Issue
- 6
- Pages
- 540-547
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2139323441
- Cited by
- 278
- References
- 1
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chan, P. H., Longar, S., & Fishman, R. A. (1987). Protective effects of liposome‐entrapped superoxide dismutase on posttraumatic brain edema. Annals of Neurology. https://doi.org/10.1002/ana.410210604
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
