The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Abstract
It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury. Although there are certainly multiple components to clinical ischemic and reperfusion injury, it appears likely that free-radical production may make a major contribution at certain stages in the progression of the injury. The primary source of superoxide in reperfused reoxygenated tissues appears to be the enzyme xanthine oxidase, released during ischemia by a calcium-triggered proteolytic attack on xanthine dehydrogenase. Reperfused tissues are protected in a variety of laboratory models by scavengers of superoxide radicals or hydroxyl radicals or by allopurinol or other inhibitors of xanthine oxidase. Dysfunction induced by free radicals may thus be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
l-citrulline supplementation can avoid the formation of detrimental high ADMA levels.
“This supplementation can avoid the formation of detrimental high ADMA levels (632).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [632]
Xanthine oxidase catalyzes the oxidation of xanthine to uric acid (antioxidant) accompanied by the formation of superoxide radical anion, O2·−, and hydrogen peroxide.
“Xanthine oxidase catalyzes the oxidation of xanthine to uric acid (antioxidant) accompanied by the formation of superoxide radical anion, O2·−, and hydrogen peroxide (McCord 1985).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as McCord 1985
Citations
Cites
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Self-citationThe Reduction of Cytochrome c by Milk Xanthine Oxidase
McCord, J. M., & Fridovich, I. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91929-0 · Cited by 1,196
Self-citationSuperoxide radicals in feline intestinal ischemia
Granger, D. N., Rutili, G., & McCord, J. M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90648-x · Cited by 1,184
Self-citationSuperoxide Radical: An Endogenous Toxicant
Fridovich, I. (1983) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.23.040183.001323 · Cited by 1,168
Ischemic injury in the cat small intestine: Role of superoxide radicals
Parks, D. A., Bulkley, G. B., Granger, D. N., Hamilton, S. R., & McCord, J. M. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90115-9 · Cited by 741
Self-citationМеерсон, Ф. З., Kagan, V. E., Kozlov, Y. P., Belkina, L. M., & Arkhipenko, Y. V. (1982) · Basic Research in Cardiology · doi:10.1007/bf01907940 · Cited by 521
The effect of hyperoxia on superoxide production by lung submitochondrial particles
Turrens, J. F., Freeman, B. Α., Levitt, J. G., & Crapo, J. D. (1982) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(82)90518-5 · Cited by 448
Corte, E. D., & Stirpe, F. (1972) · Biochemical Journal · doi:10.1042/bj1260739 · Cited by 437
Role of oxygen-derived free radicals in digestive tract diseases.
Parks, D. A., Bulkley, G. B., & Granger, D. N. (1983) · PubMed · Cited by 367
Shlafer, M., Kane, P. F., & Kirsh, M. M. (1982) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)37178-8 · Cited by 335
The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps
Manson, P. N., Anthenelli, R. M., IM, M. J. C., Bulkley, G. B., & Hoopes, J. E. (1983) · Annals of Surgery · doi:10.1097/00000658-198307000-00017 · Cited by 243
Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat
Battelli, M. G., Corte, E. D., & Stirpe, F. (1972) · Biochemical Journal · doi:10.1042/bj1260747 · Cited by 192
Responses of the ischemic myocardium to allopurinol
DeWall, R. A., Vasko, K. A., Stanley, E. L., & Kezdi, P. (1971) · American Heart Journal · doi:10.1016/0002-8703(71)90302-4 · Cited by 181
Effect of allopurinol on hemorrhagic shock
Crowell, J. W., Ce, J., & Ee, S. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.4.744 · Cited by 139
Effect of Allopurinol on the Survival of Hyperemic Island Skin Flaps
IM, M. J. C., Shen, W.-H., Pak, C. J., et al. (1984) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198402000-00023 · Cited by 119
Effect of local arterial hypotension on cat intestinal capillary permeability
Granger, D. N., Sennett, M., McElearney, P., et al. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90372-8 · Cited by 92
Toledo-Pereyra, L. H., Simmons, R. L., & Najarian, J. S. (1974) · Annals of Surgery · doi:10.1097/00000658-197411000-00012 · Cited by 79
Super oxide and ischemia : Conversion of xanthine dehydrogenase to xanthine oxidase
Roy, R. (1983) · Medical Entomology and Zoology · Cited by 72
Sackler, M. L. (1966) · Journal of Histochemistry & Cytochemistry · doi:10.1177/14.4.326 · Cited by 70
Acute necrosis of the intestinal mucosa
Bounous, G. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90084-1 · Cited by 68
Significance of increased blood uric acid following extensive hemorrhage
Jones, C., Crowell, J. W., & Smith, E. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.214.6.1374 · Cited by 50
Effect of a Xanthine Oxidase Inhibitor on Adenine Nucleotide Degradation in Hemorrhagic Shock
Cunningham, S. K., & Keaveny, T. V. (2008) · European Surgical Research · doi:10.1159/000128020 · Cited by 41
Possible role for calmodulin in calcium paradox-induced heart failure
Schaffer, S. W., Roy, R. S., & McMcord, J. M. (1983) · European Heart Journal · doi:10.1093/eurheartj/4.suppl_h.81 · Cited by 41
ALLOPURINOL AND HYPOXANTHINE PRETREATMENT OF CANINE KIDNEY DONORS
Owens, M. L., Lazarus, H. M., Wolcott, M. W., Maxwell, J. G., & Taylor, J. B. (1974) · Transplantation · doi:10.1097/00007890-197404000-00015 · Cited by 40
Splanchnic organ adenine nucleotides and their metabolites in haemorrhagic shock
Cunningham, S. K., & Keaveny, T. V. (1977) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf03030948 · Cited by 31
Flagged first, then by citations
Research works printed but not linked: 8
- Haglund, 1978, Fed Proc, 37, 2729
- Parks, 1983, Surgery, 94, 415
- Schoenberg M, Younes M, Muhl E, Sellin D, Fredholm B, Schildberg FW. Free radical involvement in ischemic damage of the small intestine. In: Greenwald R, Cohen G, eds. Oxy radicals and their scavenger systems. Vol. 2. Cellular and molecular aspects. New York: Elsevier Science, 1983:154–7.
- Grøgaard, 1982, Am J Physiol, 242, G448
- Parks, 1982, Fed Proc, 41, 1742
- Shlafer, 1982, Circulation, 66, I-85
- Stewart, 1982, Surg Forum, 33, 317
- Casale, 1983, Surg Forum, 34, 313
Cited by
Sorted by citations
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Self-citationThe mononuclear molybdenum enzymes
Hille, R., Hall, J., & Basu, P. (2014) · Chemical Reviews · doi:10.1021/cr400443z · Cited by 1,738
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
Phagocytes and oxidative stress
Babior, B. M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00481-2 · Cited by 1,061
Obstructive sleep apnoea syndrome – an oxidative stress disorder
Lavie, L. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0261 · Cited by 993
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Mori, K., Lee, H. T., Rapoport, D., Drexler, I. R., Foster, K., Yang, J., Schmidt-Ott, K. M., Chen, X., Li, J. Y., Weiss, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23056 · Cited by 954
Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769
Free Radical Pathways in CNS Injury
LEWÉN, A., MATZ, P., & CHAN, P. H. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.871 · Cited by 759
Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
MCEWEN, B. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00027-1 · Cited by 753
Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Nishino, T., & Pai, E. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10723 · Cited by 733
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Allopurinol Improves Endothelial Dysfunction in Chronic Heart Failure
Farquharson, C. A. J., Butler, R., Hill, A., Belch, J. J. F., & Struthers, A. D. (2002) · Circulation · doi:10.1161/01.cir.0000022140.61460.1d · Cited by 504
Tumor hypoxia and malignant progression
Vaupel, P., Mayer, A., & Höckel, M. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)81023-1 · Cited by 496
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491
Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy
Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436
An Extremely Potent Inhibitor of Xanthine Oxidoreductase
Okamoto, K., Eger, B. T., Nishino, T., Kondo, S., Pai, E. F., & Nishino, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208307200 · Cited by 434
An Attempt to Prevent Senescence: A Mitochondrial Approach
Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.12.008 · Cited by 430
Nitric oxide as an antioxidant
Kanner, J., Harel, S., & Rina, G. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90452-o · Cited by 429
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333
Dietary iron intake and risk of coronary disease among men.
Ascherio, A., Willett, W. C., Rimm, E. B., Giovannucci, E. L., & Stampfer, M. J. (1994) · Circulation · doi:10.1161/01.cir.89.3.969 · Cited by 286
Amaya, Y., Yamazaki, K., Sato, M., Noda, K., Nishino, T., & Nishino, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77283-9 · Cited by 275
Petrosillo, G., Francesca, M. R., Di Venosa, N., & Paradies, A. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0729fje · Cited by 261
Battelli, M. G., Bolognesi, A., & Polito, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.022 · Cited by 256
“In particular, attention has been focused on the role of XOR-derived ROS in the pathogenesis of tissue lesions induced by reperfusion after ischaemia (reviewed in [16,146]).”
BackgroundZhang, Z., Naughton, D., Winyard, P. G., Benjamin, N., Blake, D. R., & Symons, M. C. R. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9226 · Cited by 246
Effect of Iron Chelation Therapy on Recovery from Deep Coma in Children with Cerebral Malaria
Gordeuk, V., Thuma, P., Brittenham, G., McLaren, C., Parry, D., Backenstose, A., Biemba, G., Msiska, R., Holmes, L., McKinley, E., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199211193272101 · Cited by 210
Role of free radicals in viral pathogenesis and mutation
Akaike, T. (2001) · Reviews in Medical Virology · doi:10.1002/rmv.303 · Cited by 207
Hyperuricemia and xanthine oxidase in preeclampsia, revisited
Many, A., Hubel, C. A., & Roberts, J. M. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70410-6 · Cited by 187
Cameron, N. E., Cotter, M. A., & Maxfield, E. K. (1993) · Diabetologia · doi:10.1007/bf00400231 · Cited by 181
Superoxide dependent iron release from ferritin in inflammatory diseases
Biemond, P., Swaak, A. J. G., van Eijk, H. G., & Koster, J. F. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90026-3 · Cited by 182
Giraldez, R. R., Panda, A., Xia, Y., Sanders, S. P., & Zweier, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21420 · Cited by 180
Biemond, P., Swaak, A. J. G., Beindorff, C. M., & Koster, J. F. (1986) · Biochemical Journal · doi:10.1042/bj2390169 · Cited by 179
Mitochondrial Generation of Oxygen Radicals During Reoxygenation of Ischemic Tissues
Turrens, J. F., Beconi, M., Barilla, J., Chavez, U. B., & McCord, J. M. (1991) · Free Radical Research Communications · doi:10.3109/10715769109145847 · Cited by 177
Self-citationOxidative stress in skeletal muscle atrophied by immobiIization
KONDO, H., MIURA, M., & ITOKAWA, Y. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09191.x · Cited by 150
Cameron, N. E., & Cotter, M. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118104 · Cited by 147
Brown, J. M., Terada, L. S., Grosso, M. A., Whitmann, G. J., Velasco, S. E., Patt, A., Harken, A. H., & Repine, J. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113448 · Cited by 137
Regulation of xanthine oxidase by nitric oxide and peroxynitrite
Lee, C.-I., Liu, X., & Zweier, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9369 · Cited by 140
Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications
Casas, A. I., Dao, V. T.-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., et al. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6433 · Cited by 136
Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall
Zweier, J. L., Li, H., Samouilov, A., & Liu, X. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.12.004 · Cited by 132
De Pascali, F., Hemann, C., Samons, K., Chen, C.-A., & Zweier, J. L. (2014) · Biochemistry · doi:10.1021/bi500076r · Cited by 131
Iron and 8-isoprostane levels in acute and chronic wounds
Yeoh-Ellerton, S., & Stacey, M. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12471.x · Cited by 125
Gao, X., Feng, G., Manghnani, P. N., Hu, F., Jiang, N., Liu, J., Liu, B., Sun, J. Z., & Tang, B. Z. (2017) · Chemical Communications · doi:10.1039/c6cc09307h · Cited by 121
Portugal, M., Barak, V., Ginsburg, I., & Kohen, R. (2007) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.05.010 · Cited by 121
Iron Chelation Therapy for Malaria
Mabeza, G. F., Loyevsky, M., Gordeuk, V. R., & Weiss, G. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00037-0 · Cited by 111
Increased xanthine oxidase in the thalamus and putamen in depression
Michel, T. M., Camara, S., Tatschner, T., Frangou, S., Sheldrick, A. J., Riederer, P., & Grünblatt, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802123695 · Cited by 114
Krishna, C. M., Liebmann, J. E., Kaufman, D., DeGraff, W., Hahn, S. M., McMurry, T., Mitchell, J. B., & Russo, A. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90142-j · Cited by 110
Rak, R., Chao, D. L., Pluta, R. M., Mitchell, J. B., Oldfield, E. H., & Watson, J. C. (2000) · Journal of Neurosurgery · doi:10.3171/jns.2000.92.4.0646 · Cited by 106
Bonini, M. G., Miyamoto, S., Mascio, P. D., & Augusto, O. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406929200 · Cited by 99
The Reaction of Reduced Xanthine Dehydrogenase with Molecular Oxygen
Harris, C. M., & Massey, V. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8370 · Cited by 96
Kundu, T. K., Velayutham, M., & Zweier, J. L. (2012) · Biochemistry · doi:10.1021/bi3000879 · Cited by 93
Nishino, T., & Nishino, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29859 · Cited by 93
Mast Cells in Allergic and Inflammatory Diseases
Sismanopoulos, N., Delivanis, D.-A., Alysandratos, K.-D., Angelidou, A., Therianou, A., Kalogeromitros, D., & C. Theoharides, T. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212800165997 · Cited by 87
Kundu, T. K., Hille, R., Velayutham, M., & Zweier, J. L. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.12.032 · Cited by 83
Dietary haem iron and coronary heart disease in women
van der A, D. L., Peeters, P. H. M., Grobbee, D. E., Marx, J. J. M., & van der Schouw, Y. T. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi027 · Cited by 78
Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia
Poss, W. B., Huecksteadt, T. P., Panus, P. C., Freeman, B. A., & Hoidal, J. R. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.270.6.l941 · Cited by 79
Rouquette, M., Page, S., Bryant, R., Benboubetra, M., Stevens, C. R., Blake, D. R., Whish, W. D., Harrison, R., & Tosh, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00385-8 · Cited by 78
Kozlov, A. V., Dietrich, B., & Nohl, H. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705323 · Cited by 69
Molecular and biochemical changes of the cardiovascular system due to smoking exposure
Armani, C., Landini Jr., L., & Leone, A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787846973 · Cited by 68
Bar-Or, D., Thomas, G. W., Rael, L. T., Lau, E. P., & Winkler, J. V. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4533 · Cited by 68
Tauler, P., Aguiló, A., Fuentespina, E., Tur, J., & Pons, A. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-001-0770-0 · Cited by 65
Protective effect of melanocortin peptides in rat myocardial ischemia
Bazzani, C., Guarini, S., Botticelli, A. R., Zaffe, D., Tomasi, A., Bini, A., Cainazzo, M. M., Ferrazza, G., Mioni, C., & Bertolini, A. (2001) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29636-1 · Cited by 59
Müller, M. J., Vollmar, B., Friedl, H.-P., & Menger, M. D. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00028-7 · Cited by 51
Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress
Droy-Lefaix, M. T. (1997) · AGE · doi:10.1007/s11357-997-0013-1 · Cited by 49
Martini, S., Austin, T., Aceti, A., Faldella, G., & Corvaglia, L. (2020) · Pediatric Research · doi:10.1038/s41390-019-0639-6 · Cited by 50
Allopurinol, Xanthine Oxidase, and Cardiac Ischemia
Lee, B. E., Toledo, A. H., Anaya-Prado, R., Roach, R. R., & Toledo-Pereyra, L. H. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181bca50c · Cited by 46
Deferoxamine decreases necrosis in dorsally based pig skin flaps.
Weinstein, G. S., Maves, M. D., & McCormack, M. L. (1989) · Otolaryngology–Head and Neck Surgery · doi:10.1177/019459988910100508 · Cited by 29
Manganese Superoxide Dismutase Modulates Interleukin-1α Levels in HT-1080 Fibrosarcoma Cells
Melendez, J. A., & Davies, K. J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18898 · Cited by 28
Haj-Yehia, A. I., Nassar, T., Assaf, P., Nassar, H., & Änggård, E. E. (1999) · Antioxidants & Redox Signaling · doi:10.1089/ars.1999.1.2-221 · Cited by 25
Effects of remifentanil preconditioning on osteoblasts under hypoxia-reoxygenation condition
Baik, S.-W., Park, B.-S., Kim, Y.-H., Kim, Y.-D., Kim, C.-H., Yoon, J.-Y., & Yoon, J.-U. (2015) · International Journal of Medical Sciences · doi:10.7150/ijms.11839 · Cited by 14
Kazmi, S. S. H., Safi, N., Berge, S. T., Kazmi, M., Sundhagen, J. O., Julien, K., Thorsby, P. M., Ånonsen, K. V., Medhus, A. W., & Hisdal, J. (2022) · Vascular Health and Risk Management · doi:10.2147/vhrm.s365625 · Cited by 7
Metadata
- Authors
- Epstein, F. H., & McCord, J. M.
- Affiliations
- University of South Alabama (US)
- Corresponding author
- McCord, Joe M.
- ORCID
- McCord, Joe M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-01-17
- Volume
- 312
- Issue
- 3
- Pages
- 159-163
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2097744068
- Cited by
- 5,399
- References
- 25
- Citations by year
- 2026: 9 · 2025: 24 · 2024: 27 · 2023: 40 · 2022: 34 · 2021: 61 · 2020: 60 · 2019: 58 · 2018: 66 · 2017: 64 · 2016: 72 · 2015: 91 · 2014: 122 · 2013: 104 · 2012: 118
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxygen free radicals, ischemia-reperfusion injury, superoxide, xanthine oxidase, xanthine dehydrogenase, hydroxyl radicals, superoxide scavengers, allopurinol, tissue damage
- MeSH terms
- Animals, Calcium, Coronary Disease, Free Radicals, Humans, Intestines, Ischemia, Shock, Superoxides, Transplantation, Xanthine Dehydrogenase, Xanthine Oxidase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
