The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.
Open accessAbstract
The extent to which polymorphonuclear leukocytes and monocytes/macrophages contribute to the pathobiology of cerebral ischemia and stroke is an issue of long-standing contradiction and controversy. Recent developments in the ability to selectively modify leukocyte adhesion with antiadhesion antibodies and the potential clinical application of this therapeutic approach have spurred a resurgence of experimental studies examining the role of leukocytes in cerebral ischemia and stroke. We review studies examining leukocyte accumulation, initiation of thrombosis, and exacerbation of ischemic brain injury in stroke, and we examine other proposed contributions of leukocytes to cerebrovascular pathophysiology. The importance of specific characteristics of a given ischemia model and of underlying stroke risk factors in determining the degree of leukocyte involvement and effectiveness of therapies directed against these cells is discussed.
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Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Induction of reproducible brain infarction by photochemically initiated thrombosis
Watson, B. D., Dietrich, W. D., Busto, R., Wachtel, M. S., & Ginsberg, M. D. (1985) · Annals of Neurology · doi:10.1002/ana.410170513 · Cited by 1,135
Interleukin 1 of the central nervous system is produced by ameboid microglia.
Giulian, D., Baker, T. J., Shih, L. C., & Lachman, L. B. (1986) · The Journal of experimental medicine · doi:10.1084/jem.164.2.594 · Cited by 859
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Tumor Necrosis Factor-α: A Mediator of Focal Ischemic Brain Injury
Barone, F. C., Arvin, B., White, R. F., Miller, A., Webb, C. L., Willette, R. N., Lysko, P. G., & Feuerstein, G. Z. (1997) · Stroke · doi:10.1161/01.str.28.6.1233 · Cited by 863
Soares, H., Hicks, R., Smith, D., & McIntosh, T. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08223.1995 · Cited by 379
Mabuchi, T., Kitagawa, K., Ohtsuki, T., Kuwabara, K., Yagita, Y., Yanagihara, T., Hori, M., & Matsumoto, M. (2000) · Stroke · doi:10.1161/01.str.31.7.1735 · Cited by 280
Guido, S., Sebastian, J., & Schroeter, M. (2003) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0123-7_3 · Cited by 276
Metadata
- Authors
- Kochanek, P. M., & Hallenbeck, J. M.
- Venue
- Stroke
- Published
- 1992-09
- Volume
- 23
- Issue
- 9
- Pages
- 1367-1379
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2050694917
- Cited by
- 615
- References
- 3
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kochanek, P. M., & Hallenbeck, J. M. (1992). Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke. https://doi.org/10.1161/01.str.23.9.1367
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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