The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Abnormal glutamate metabolism in amyotrophic lateral sclerosis
Abstract
Glutamate levels were determined in the fasting plasma of 22 patients with early‐stage primary amyotrophic lateral sclerosis (ALS) and compared to those of healthy and diseased controls. There was a significant increase (by approximately 100%, p < 0.0005) in the plasma glutamate of the ALS patients as compared with the controls. Oral glutamate loading (60 mg of monosodium glutamate per kilogram of body weight, taken orally after overnight fasting) resulted in significantly greater elevations in the plasma glutamate and aspartate levels in the ALS patients than in the controls. Glutamate, a potentially neuroexcitotoxic compound, is thought to be the transmitter of the corticospinal tracts and certain spinal cord interneurons. A systemic defect in the metabolism of this amino acid may underlie primary ALS.
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Cites
Glutamate and the pathophysiology of hypoxic–ischemic brain damage
Rothman, S. M., & Olney, J. W. (1986) · Annals of Neurology · doi:10.1002/ana.410190202 · Cited by 2,428
Olney, J. W., Ho, O., & Rhee, V. (1971) · Experimental Brain Research · doi:10.1007/bf00234911 · Cited by 802
Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist
Wieloch, T. (1985) · Science · doi:10.1126/science.2996146 · Cited by 673
Tandan, R., & Bradley, W. G. (1985) · Annals of Neurology · doi:10.1002/ana.410180302 · Cited by 365
Rowland, L. P. (1982) · PubMed · Cited by 348
Abnormal Glutamate Metabolism in an Adult-Onset Degenerative Neurological Disorder
Plaitakis, A., Berl, S., & Yahr, M. D. (1982) · Science · doi:10.1126/science.6121377 · Cited by 225
Self-citationThe metabolic significance of anion transport in mitochondria
Meijer, A. J., & van Dam, K. (1974) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(74)90001-9 · Cited by 223
CSF amino acids and plasma‐CSF amino acid ratios in adults1
Perry, T. L., Hansen, S., & Kennedy, J. (1975) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1975.tb07680.x · Cited by 194
Neurological disorders associated with deficiency of glutamate dehydrogenase
Plaitakis, A., Berl, S., & Yahr, M. D. (1984) · Annals of Neurology · doi:10.1002/ana.410150206 · Cited by 183
Self-citationAmyotrophic leteral sclerosis: Part 2. Etiopathogenesis
Tandan, R., & Bradley, W. G. (1985) · Annals of Neurology · doi:10.1002/ana.410180402 · Cited by 144
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Neurologic Sequelae of Domoic Acid Intoxication Due to the Ingestion of Contaminated Mussels
Teitelbaum, J. S., Zatorre, R. J., Carpenter, S., Gendron, D., Evans, A. C., Gjedde, A., & Cashman, N. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006213222505 · Cited by 555
Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro
Carriedo, S. G., Yin, H. Z., & Weiss, J. H. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04069.1996 · Cited by 441
Excitotoxic Amino Acids and Neuropsychiatric Disorders
Olney, J. W. (1990) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.000403 · Cited by 406
Metadata
- Authors
- Plaitakis, A., & Caroscio, J. T.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1987-11
- Volume
- 22
- Issue
- 5
- Pages
- 575-579
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2065845618
- Cited by
- 305
- References
- 19
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Plaitakis, A., & Caroscio, J. T. (1987). Abnormal glutamate metabolism in amyotrophic lateral sclerosis. Annals of Neurology. https://doi.org/10.1002/ana.410220503
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
