Dystonia in parkinson's disease: Clinical and pharmacological features
Abstract
We studied the features of dystonia in 9 patients with untreated idiopathic Parkinson's disease and in 56 patients on sustained treatment with L-dopa. Dystonia was seen as an initial symptom in patients with both early- and late-onset Parkinson's disease and included action dystonia of the limbs and cranial dystonia. Although the coexistence of parkinsonism and dystonia suggests a common pathophysiology, antiparkinsonian drugs did not consistently influence dystonic spasms. L-dopa-induced dystonia was seen as an off-period, biphasic, or peak-dose phenomenon. Each type showed a distinctive pattern of localization of dystonic spasms, possibly reflecting neurochemical aspects of basal ganglia somatotopy. Neuropharmacological studies performed in 12 patients suggest that off-period dystonia is genuinely induced by L-dopa and best relieved by antiparkinsonian agents.
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In reports by Poewe and colleagues, the most frequent site for off dystonia is the foot, whereas in peak dose dystonia neck and face are more commonly involved.
“In reports by Poewe and colleagues, the most frequent site for off dystonia is the foot, whereas in peak dose dystonia neck and face are more commonly involved (Poewe and Lees 1987;Poewe et al. 1988).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Poewe et al. 1988
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The clinical symptoms of Parkinson's disease.
Sveinbjornsdottir, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13691 · Cited by 1,410 · see citing works
Dystonia in Parkinson’s disease
Tolosa, E., & Compta, Y. (2006) · Journal of Neurology · doi:10.1007/s00415-006-7003-6 · Cited by 176 · see citing works
Jankovic, J., & Tintner, R. (2001) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00025-6 · Cited by 135 · see citing works
Ray Chaudhuri, K., Poewe, W., & Brooks, D. (2018) · Movement Disorders · doi:10.1002/mds.27386 · Cited by 121 · see citing works
Self-citationvan Laar, T. (2003) · CNS Drugs · doi:10.2165/00023210-200317070-00002 · Cited by 43 · see citing works
- Authors
- Poewe, W. H., Lees, A. J., & Stern, G. M.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Poewe, W. H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-01
- Volume
- 23
- Issue
- 1
- Pages
- 73-78
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2158311794
- Cited by
- 162
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 6
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- dystonia, Parkinson's disease, cranial dystonia, antiparkinsonian drugs, neuropharmacology, parkinsonism
- MeSH terms
- Adult, Aged, Circadian Rhythm, Dose-Response Relationship, Drug, Dystonia, Humans, Injections, Intravenous, Levodopa, Middle Aged, Parkinson Disease, Substance Withdrawal Syndrome
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