The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Biological differences between ischemia, hypoglycemia, and epilepsy
Abstract
Ischemia, hypoglycemia, and epilepsy have long been thought to produce similar or identical brain damage. Further more, these insults have been assumed to be additive in their damaging effects. These notions have been based on neuropathological observations in the hippocampus and cerebral cortex, and on the tenet that energy failure (ischemia. hypoglycemia) and increased demand for energy (epilepsy) similarly give rise to selective neuronal neuronal mecrosis Recently, other bases for considering these three insults identical have grown out of observations that loss of calcium homeostasis is common to all and that an excitotoxic mechanism of selective neuronal necrosis exists in all three conditions. Fundamental differences between ischemia, hypoglycemia, and epilepsy include the underlying neurochemical changes induced, the neuronal revival times, the time course of neuronal death, the distribution of selective neuronal necrosis, and the likely excitotoxins released. Lactic acid accumulation, implicated in damage to the neuropil as well as to neuronal cell bodies, also occurs to different degrees and in different distributions in the three conditions. The degree and distribution of pannecrosis is thus also different in ischemia, hypoglycemia, and epilepsy.
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Glutamate and the pathophysiology of hypoxic–ischemic brain damage
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Glutamate: A Neurotransmitter in Mammalian Brain
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Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion
Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738
Young, B. G., Jordan, K. G., & Doig, G. S. (1996) · Neurology · doi:10.1212/wnl.47.1.83 · Cited by 668
Lindvall, O., Ernfors, P., Bengzon, J., Kokaia, Z., Smith, M. L., Siesjö, B. K., & Persson, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.648 · Cited by 514
Self-citationActivation of human medial prefrontal cortex during autonomic responses to hypoglycemia
Teves, D., Videen, T. O., Cryer, P. E., & Powers, W. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307048101 · Cited by 138
Hannonen, R., Tupola, S., Ahonen, T., & Riikonen, R. (2003) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2003.tb00341.x · Cited by 106
Metadata
- Authors
- Auer, R. N., & Siesjo, B. K.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1988-12
- Volume
- 24
- Issue
- 6
- Pages
- 699-707
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2158188612
- Cited by
- 331
- References
- 63
- FWCI
- 16.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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