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Cited by 106Diabetes Management and ResearchDiabetes and associated disordersDiabetes Management and Education

Neurocognitive functioning in children with type-1 diabetes with and without episodes of severe hypoglycaemia

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Hannonen, Riitta, Tupola, Sarimari, Ahonen, Timo, Riikonen, Raili·2003·Developmental Medicine & Child Neurology
DOI 10.1111/j.1469-8749.2003.tb00341.x
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Abstract

Previous studies have shown that recurrent severe hypoglycaemia can cause long‐term cognitive impairment in children with type‐1 diabetes, but the results are controversial, possibly due to the heterogeneity of samples and lack of comprehensive neuropsychological assessments of children. The aim of this study was to assess the effects of diabetes and severe hypoglycaemia on the neurocognitive functioning of children with a standardized, wide age‐range neuropsychological test battery designed for the assessment of children. Eleven children with diabetes and a history of severe hypoglycaemia, 10 children with diabetes without a history of severe hypoglycaemia, and 10 healthy control children (a total of 31 children: 14 males and 17 females, age range 5 years 6 months to 11 years 11 months, mean 9 years 4 months, SD 1 year 11 months) were studied using the Wechsler Intelligence Scale for Children‐Revised (WISC‐R) and the NEPSY, a Developmental Neuropsychological Assessment. The NEPSY assessed development in attention and executive functions, language, sensorimotor functions, visuospatial processing, and learning and memory. Children with a history of severe hypoglycaemia had more neuropsychological impairments, more learning difficulties (as reported by parents), and needed more part‐time special education than those in the other groups. Significant differences were found in verbal short‐term memory and phonological processing. Results suggest that severe hypoglycaemia is a risk factor for learning due to deficits in auditory‐verbal functioning.

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  1. Tanner JM. (1962) Growth at Adolescence. 2nd edn. Oxford: Blackwell Scientific Publications.
  2. Waney Squier, Oxford, UK;

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Authors
Hannonen, R., Tupola, S., Ahonen, T., & Riikonen, R.
Affiliations
  • Kymenlaakson keskussairaala (FI)
  • University of Helsinki (FI)
  • University of Jyväskylä (FI)
  • University of Eastern Finland (FI)
ORCID
Venue
Developmental Medicine & Child Neurology
Publisher
Wiley
Published
2003-04
Volume
45
Issue
4
Pages
262-268
ISSN
  • 0012-1622 (ISSN-L)
  • 1469-8749
DOI
10.1111/j.1469-8749.2003.tb00341.x
OpenAlex
W2118695182
Cited by
106
References
36
Citations by year
2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 4 · 2013: 9 · 2012: 6
FWCI
1.63
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1414 d)
Locations
  • Developmental Medicine & Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
type 1 diabetes, severe hypoglycemia, neurocognitive function, children, learning difficulties, verbal short-term memory, phonological processing, executive function, attention, special education, cognitive impairment
MeSH terms
Child, Child, Preschool, Cognition Disorders, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Language Disorders, Male, Neuropsychological Tests, Perceptual Disorders, Psychomotor Disorders, Severity of Illness Index

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