Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
Abstract
To estimate the replication of the human T‐cell leukemia virus type I (HTLV‐I) in patients with HTLV‐I‐associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV‐I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV‐I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymtopmatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV‐I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV‐I DNA, indicating adult T‐cell leukemia.
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Symptomatic patients have significantly higher HTLV-1 PVL compared to asymptomatic controls.
“Previous studies have reported that symptomatic patients have significantly higher HTLV-1 PVL compared to asymptomatic controls [120,273,274,275].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [274]
Cites
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Kira, J., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, N., Sasaki, H., & Sakaki, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410290214 · Cited by 152 · see citing works
Therapeutic trials in 200 patients with HTLV-Iassociated myelopathy/tropical spastic paraparesis
Nakagawa, M., Nakahara, K., Maruyama, Y., Kawabata, M., Higuchi, I., Kubota, H., Izumo, S., Arimura, K., & Osame, M. (1996) · Journal of Neurovirology · doi:10.3109/13550289609146899 · Cited by 150 · see citing works
Self-citationNagai, M., Yamano, Y., Brennan, M. B., Mora, C. A., & Jacobson, S. (2001) · Annals of Neurology · doi:10.1002/ana.10065 · Cited by 144 · see citing works
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Self-citationCurrent State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works
- Authors
- Yoshida, M., Osame, M., Kawai, H., Toita, M., Kuwasaki, N., Nishida, Y., Hiraki, Y., Takahashi, K., Nomura, K., Sonoda, S., Eiraku, N., Ijichi, S., & Usuku, K.
- Affiliations
- The Cancer Institute Hospital (JP)
- Kagoshima University (JP)
- Tokushima University (JP)
- Kurume University (JP)
- Corresponding author
- Yoshida, Mitsuaki
- ORCID
- Ijichi, Shinji
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1989-09
- Volume
- 26
- Issue
- 3
- Pages
- 331-335
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1966528056
- Cited by
- 176
- References
- 1
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2014: 1 · 2013: 3
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- HTLV-1, tropical spastic paraparesis, viral replication, lymphocytes, asymptomatic carriers, adult T-cell leukemia/lymphoma
- MeSH terms
- Adult, DNA Replication, Female, Humans, Middle Aged, Muscular Diseases, Nucleic Acid Hybridization, Virus Replication, Leukemia-Lymphoma, Adult T-Cell, Paraparesis, Tropical Spastic
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