Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP
Abstract
To date, high human T‐cell lymphotropic virus type I proviral load in patients with human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related to the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis. However, the proviral load in cerebrospinal fluid has not been well investigated. We measured human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells from human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis patients using real‐time quantitative polymerase chain reaction (TaqMan). Human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells were significantly higher than that of the matched peripheral blood mononuclear cells, and a high ratio of human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells to peripheral blood mononuclear cells were observed in patients with short duration of illness. Human T‐cell lymphotropic virus type I Tax‐specific CD8+ T cells, as detected by peptide‐loaded HLA tetramers, accumulated in cerebrospinal fluid compared with that in peripheral blood mononuclear cells, while the frequency of cytomegalovirus‐specific CD8+ T cells in cerebrospinal fluid was reduced. These observations suggest that accumulation of both human T‐cell lymphotropic virus type I‐infected cells and preferential expansion of human T‐cell lymphotropic virus type I‐specific CD8+ cells in cerebrospinal fluid may play a role in the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis.
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Tax is associated with T cell transformation, resulting in activation and proliferation of infected cells and HTLV-1 leukaemogenesis.
“It is associated with T cell transformation, resulting in the activation and proliferation of infected cells and HTLV-1 leukaemogenesis [46,68,215,216].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
Increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression.
“There is strong evidence suggesting that increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression [216,271,272,273].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]
Cites
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011 · see citing works
ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS
Gessain, A., Vernant, J. C., Maurs, L., Barin, F., Gout, O., Calender, A., & de Thé, G. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92734-5 · Cited by 2,812 · see citing works
HTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITY
Osame, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Igata, A., Matsumoto, M., & Tara, M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91298-5 · Cited by 2,381 · see citing works
T‐lymphocyte entry into the central nervous system
Hickey, W. F., Hsu, B. L., & Kimura, H. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280213 · Cited by 1,176 · see citing works
Nagai, M., Usuku, K., Matsumoto, W., Kodama, D., Takenouchi, N., Moritoyo, T., Hashiguchi, S., Ichinose, M., Bangham, C. R., Izumo, S., et al. (1998) · Journal of Neurovirology · doi:10.3109/13550289809114225 · Cited by 694 · see citing works
Self-citationFolks, T. M. (1991) · Virus Research · doi:10.1016/0168-1702(91)90100-a · Cited by 251 · see citing works
Greten, T. F., Slansky, J. E., Kubota, R., Soldan, S. S., Jaffee, E. M., Leist, T. P., Pardoll, D. M., Jacobson, S., & Schneck, J. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7568 · Cited by 247 · see citing works
Self-citationIsolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis
Jacobson, S., Raine, C. S., Mingioli, E. S., & McFarlin, D. E. (1988) · Nature · doi:10.1038/331540a0 · Cited by 246 · see citing works
Self-citationElovaara, I., Koenig, S., Brewah, A., Woods, R. M., Lehky, T., & Jacobson, S. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.6.1567 · Cited by 197 · see citing works
Self-citationFratricide among CD8+ T Lymphocytes Naturally Infected with Human T Cell Lymphotropic Virus Type I
Hanon, E., Stinchcombe, J. C., Saito, M., Asquith, B., Taylor, G. P., Tanaka, Y., Weber, J. N., Griffiths, G. M., & Bangham, C. R. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00065-0 · Cited by 176 · see citing works
Increased replication of HTLV‐I in HTLV‐I–associated myelopathy
Yoshida, M., Osame, M., Kawai, H., Toita, M., Kuwasaki, N., Nishida, Y., Hiraki, Y., Takahashi, K., Nomura, K., Sonoda, S., et al. (1989) · Annals of Neurology · doi:10.1002/ana.410260304 · Cited by 176 · see citing works
CD8+ T cells are an in vivo reservoir for human T-cell lymphotropic virus type I
Nagai, M., Brennan, M. B., Sakai, J. A., Mora, C. A., & Jacobson, S. (2001) · Blood · doi:10.1182/blood.v98.6.1858 · Cited by 168 · see citing works
Self-citationKira, J., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, N., Sasaki, H., & Sakaki, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410290214 · Cited by 152 · see citing works
Bieganowska, K. D., Höllsberg, P., Buckle, G. J., Lim, D., Greten, T. F., Schneck, J. P., Altman, J. D., Jacobson, S., Ledis, S. L., Hanchard, B., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1765 · Cited by 134 · see citing works
Self-citationSolache, A., Morgan, C. L., Dodi, A. I., Morte, C., Scott, I., BABOONIAN, C., Zal, B., Goldman, J. M., Grundy, J. E., & Madrigal, J. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5512 · Cited by 134 · see citing works
Nagai, M., Kubota, R., Greten, T. F., Schneck, J. P., Leist, T. P., & Jacobson, S. (2001) · The Journal of Infectious Diseases · doi:10.1086/317932 · Cited by 131 · see citing works
Self-citationGessain, A., Saal, F., Gout, O., Daniel, M., Flandrin, G., de The, G., Peries, J., & Sigaux, F. (1990) · Blood · doi:10.1182/blood.v75.2.428.428 · Cited by 130 · see citing works
Cavrois, M., Antoine Gessain, A., Gout, O., Wain–Hobson, S., & Wattel, E. (2000) · The Journal of Infectious Diseases · doi:10.1086/315844 · Cited by 72 · see citing works
Sakai, J. A., Nagai, M., Brennan, M. B., Mora, C. A., & Jacobson, S. (2001) · Blood · doi:10.1182/blood.v98.5.1506 · Cited by 69 · see citing works
Self-citationMoritoyo, T., Izumo, S., Moritoyo, H., Tanaka, Y., Kiyomatsu, Y., Nagai, M., Usuku, K., Sorimachi, M., & Osame, M. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909015810 · Cited by 66 · see citing works
Self-citationMor, F., & Cohen, I. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116136 · Cited by 66 · see citing works
Mori, M., Kinoshita, K.-I., Ban, N., Yamada, Y., & Shiku, H. (1988) · Annals of Neurology · doi:10.1002/ana.410240220 · Cited by 47 · see citing works
Ijichi, S., Eiraku, N., Osame, M., Izumo, S., Kubota, R., Maruyama, I., Matsumoto, M., Niimura, T., & Sonoda, S. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90143-4 · Cited by 46 · see citing works
Puccioni‐Sohler, M., Rios, M., Bianco, C., Zhu, S. W., Oliveira, C., Novis, S. A. P., & Pombo‐de‐Oliveira, M. S. (1999) · Neurology · doi:10.1212/wnl.53.6.1335 · Cited by 31 · see citing works
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Cited by
Sorted by citations
Yamano, Y., & Sato, T. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00389 · Cited by 202 · see citing works
Self-citationComparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2
Feuer, G., & Green, P. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208971 · Cited by 169 · see citing works
Yamano, Y., Takenouchi, N., Li, H., Tomaru, U., Yao, K., Grant, C. W., Maric, D., & Jacobson, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23913 · Cited by 168 · see citing works
Self-citationFutsch, N., Mahieux, R., & Dutartre, H. (2017) · Viruses · doi:10.3390/v10010001 · Cited by 155 · see citing works
Immunopathogenesis of Human T Cell Lymphotropic Virus Type I–Associated Neurologic Disease
Jacobson, S. (2002) · The Journal of Infectious Diseases · doi:10.1086/344269 · Cited by 152 · see citing works
Self-citationInflammatory manifestations of HTLV-1 and their therapeutic options
Martin, F., Taylor, G. P., & Jacobson, S. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.966690 · Cited by 148 · see citing works
Self-citationTelomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
Bellon, M., & Nicot, C. (2017) · Viruses · doi:10.3390/v9100289 · Cited by 146 · see citing works
Olindo, S., Lézin, A., Cabre, P., Merle, H., Saint-Vil, M., Edimonana-Kaptue, M., Signaté, A., Césaire, R., & Smadja, D. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.010 · Cited by 142 · see citing works
Yamano, Y., Araya, N., Sato, T., Utsunomiya, A., Azakami, K., Hasegawa, D., Izumi, T., Fujita, H., Aratani, S., Yagishita, N., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006517 · Cited by 140 · see citing works
Self-citationBrunetto, G. S., Massoud, R., Leibovitch, E. C., Caruso, B. P., Johnson, K. R., Ohayon, J. M., Fenton, K. M., Cortese, I. C. M., & Jacobson, S. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0249-3 · Cited by 123 · see citing works
Self-citationHTLV-1 induces a Th1-like state in CD4+CCR4+ T cells
Araya, N., Sato, T., Ando, H., Tomaru, U., Yoshida, M., Coler-Reilly, A. L. G., Yagishita, N., Yamauchi, J., Hasegawa, A., Kannagi, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75250 · Cited by 114 · see citing works
Self-citationHTLV-1, Immune Response and Autoimmunity
Quaresma, J. A. S., Yoshikawa, G. T., Koyama, R. V. L., Dias, G., Fujihara, S., & Fuzii, H. T. (2015) · Viruses · doi:10.3390/v8010005 · Cited by 107 · see citing works
Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy
Ando, H., Sato, T., Tomaru, U., Yoshida, M., Utsunomiya, A., Yamauchi, J., Araya, N., Yagishita, N., Coler-Reilly, A. L. G., Shimizu, Y., et al. (2013) · Brain · doi:10.1093/brain/awt183 · Cited by 104 · see citing works
Self-citationYamano, Y., Cohen, C. J., Takenouchi, N., Yao, K., Tomaru, U., Li, H., Reiter, Y., & Jacobson, S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032042 · Cited by 105 · see citing works
Self-citationTakenouchi, N., Yamano, Y., Usuku, K., Osame, M., & Izumo, S. (2003) · Journal of NeuroVirology · doi:10.1080/13550280390173418 · Cited by 98 · see citing works
Self-citationLézin, A., Olindo, S., Olière, S., Varrin‐Doyer, M., Marlin, R., Cabre, P., Smadja, D., & Césaire, R. (2005) · The Journal of Infectious Diseases · doi:10.1086/429962 · Cited by 96 · see citing works
Olière, S., Hernandez, E., Lézin, A., Arguello, M., Douville, R. N., Nguyên, T. L.-A., Olindo, S., Panelatti, G., Kazanji, M., Wilkinson, P. A., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001177 · Cited by 88 · see citing works
Goon, P. K. C., Biancardi, A., Fast, N. M., Igakura, T., Hanon, E., Mosley, A. J., Asquith, B., Gould, K. G., Marshall, S. E., Taylor, G. P., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/420832 · Cited by 88 · see citing works
Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
Enose-Akahata, Y., Vellucci, A., & Jacobson, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02563 · Cited by 88 · see citing works
Self-citationCytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases
Futsch, N., Prates, G. D. S., Mahieux, R., Casseb, J., & Dutartre, H. (2018) · Viruses · doi:10.3390/v10120691 · Cited by 87 · see citing works
Yakova, M., Lézin, A., Dantin, F., Lagathu, G., Olindo, S., Jean-Baptiste, G., Arfi, S., & Césaire, R. (2005) · Retrovirology · doi:10.1186/1742-4690-2-4 · Cited by 87 · see citing works
Human T-Cell Lymphotropic Virus Type I and Neurological Diseases
Nagai, M., & Osame, M. (2003) · Journal of NeuroVirology · doi:10.1080/13550280390194028 · Cited by 83 · see citing works
Self-citationInterferon‐β1a therapy in human T‐lymphotropic virus type I–associated neurologic disease
Oh, U., Yamano, Y., Mora, C. A., Ohayon, J., Bagnato, F., Butman, J. A., Dambrosia, J., Leist, T. P., McFarland, H., & Jacobson, S. (2005) · Annals of Neurology · doi:10.1002/ana.20429 · Cited by 74 · see citing works
Self-citationVeroni, C., & Aloisi, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665718 · Cited by 73 · see citing works
Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system
Cinque, P. M., Bossolasco, S., & Lundkvist, Å. (2003) · Journal of Clinical Virology · doi:10.1016/s1386-6532(02)00173-7 · Cited by 69 · see citing works
Araya, N., Takahashi, K., Sato, T., Nakamura, T., Sawa, C., Hasegawa, D., Ando, H., Aratani, S., Yagishita, N., Fujii, R., et al. (2010) · Antiviral Therapy · doi:10.3851/imp1699 · Cited by 66 · see citing works
Self-citationYamauchi, J., Araya, N., Yagishita, N., Sato, T., & Yamano, Y. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107669 · Cited by 63 · see citing works
Self-citationMatsuzaki, T., Saito, M., Usuku, K., Nose, H., Izumo, S., Arimura, K., & Osame, M. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.05.011 · Cited by 65 · see citing works
Gómez-Acevedo, H., Li, M. Y., & Jacobson, S. (2009) · Bulletin of Mathematical Biology · doi:10.1007/s11538-009-9465-z · Cited by 64 · see citing works
Self-citationFukumoto, R., Dundr, M., Nicot, C., Adams, A., Valeri, V. W., Samelson, L. E., & Franchini, G. (2007) · Journal of Virology · doi:10.1128/jvi.02703-06 · Cited by 64 · see citing works
Oh, U., & Jacobson, S. (2008) · Neurologic Clinics · doi:10.1016/j.ncl.2008.03.008 · Cited by 63 · see citing works
Self-citationAraya, N., Sato, T., Yagishita, N., Ando, H., Utsunomiya, A., Jacobson, S., & Yamano, Y. (2011) · Viruses · doi:10.3390/v3091532 · Cited by 62 · see citing works
Self-citationNeuroimmunity of HTLV-I Infection
Matsuura, E., Yamano, Y., & Jacobson, S. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-010-9216-9 · Cited by 62 · see citing works
Self-citationGoon, P. K. C., Igakura, T., Hanon, E., Mosley, A. J., Asquith, B., Gould, K. G., Taylor, G. P., Weber, J. N., & Bangham, C. R. M. (2003) · Journal of Virology · doi:10.1128/jvi.77.17.9716-9722.2003 · Cited by 61 · see citing works
Azakami, K., Sato, T., Araya, N., Utsunomiya, A., Kubota, R., Suzuki, K., Hasegawa, D., Izumi, T., Fujita, H., Aratani, S., et al. (2009) · Blood · doi:10.1182/blood-2009-02-203042 · Cited by 59 · see citing works
Self-citationYamano, Y., & Coler-Reilly, A. L. G. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.012 · Cited by 56 · see citing works
Self-citationAnderson, M. R., Pleet, M. L., Enose‐Akahata, Y., Erickson, J. W., Monaco, M. C., Akpamagbo, Y., Velluci, A., Tanaka, Y., Azodi, S., Lepene, B., et al. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-018-0204-7 · Cited by 52 · see citing works
Self-citationImmunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP)
Fuzii, H. T., Dias, G. A. D. S., de Barros, R. J. S., Falcão, L. F. M., & Quaresma, J. A. S. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.03.025 · Cited by 53 · see citing works
Saito, M., Nakagawa, M., Kaseda, S., Matsuzaki, T., Jonosono, M., Eiraku, N., Kubota, R., Takenouchi, N., Nagai, M., Furukawa, Y., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/380101 · Cited by 52 · see citing works
Self-citationNozuma, S., & Jacobson, S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00885 · Cited by 51 · see citing works
Self-citationImmunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Enose-Akahata, Y., & Jacobson, S. (2019) · Retrovirology · doi:10.1186/s12977-019-0499-5 · Cited by 49 · see citing works
Self-citationCo-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence
Pise-Masison, C. A., de Castro‐Amarante, M. F., Enose‐Akahata, Y., Buchmann, R. C., Fenizia, C., Parks, R. W., Edwards, D. C., Fiocchi, M., Alcantara, L. C., Bialuk, I., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004454 · Cited by 49 · see citing works
Self-citationNascimento, M., Primo, J., Bittencourt, A. L., de Siqueira, I. C., de Oliveira, M. D. F. S. P., Meyer, R., Schriefer, A., Santos, S., & Carvalho, E. M. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03869.x · Cited by 49 · see citing works
Montanheiro, P., de Oliveira, A. C. P., Smid, J., Fukumori, L. M. I., Olah, I., Duarte, A. J. D. S., & Casseb, J. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02291.x · Cited by 47 · see citing works
Tumor immunity against adult T‐cell leukemia
Kannagi, M., Harashima, N., Kurihara, K., Ohashi, T., Utsunomiya, A., Tanosaki, R., Masuda, M., Tomonaga, M., & Okamura, J. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00050.x · Cited by 47 · see citing works
Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals
Enose‐Akahata, Y., Abrams, A., Massoud, R., Bialuk, I., Johnson, K. R., Green, P. L., Maloney, E. M., & Jacobson, S. (2013) · Retrovirology · doi:10.1186/1742-4690-10-19 · Cited by 45 · see citing works
Self-citationComprehensive Analysis of TCR-β Repertoire in Patients with Neurological Immune-mediated Disorders
Sousa, A. D. P. A., Johnson, K. R., Ohayon, J. M., Zhu, J., Muraro, P. A., & Jacobson, S. (2019) · Scientific Reports · doi:10.1038/s41598-018-36274-7 · Cited by 45 · see citing works
Self-citationPresence of HTLV-I Tax protein in cerebrospinal fluid from HAM/TSP patients
Cartier, L., & Ramírez, E., V (2004) · Archives of Virology · doi:10.1007/s00705-004-0443-3 · Cited by 44 · see citing works
Kuramitsu, M., Sekizuka, T., Yamochi, T., Firouzi, S., Sato, T., Umeki, K., Sasaki, D., Hasegawa, H., Kubota, R., Sobata, R., et al. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00659-17 · Cited by 42 · see citing works
Self-citationMori, S. (2005) · Thorax · doi:10.1136/thx.2004.021667 · Cited by 41 · see citing works
The Antiproliferative Effect of Kefir Cell-Free Fraction on HuT-102 Malignant T Lymphocytes
Rizk, S. E., Maalouf, K., & Baydoun, E. (2009) · Clinical Lymphoma & Myeloma · doi:10.3816/clm.2009.s.012 · Cited by 40 · see citing works
Enose‐Akahata, Y., Abrams, A., Johnson, K. R., Maloney, E. M., & Jacobson, S. (2012) · Blood · doi:10.1182/blood-2011-11-390807 · Cited by 38 · see citing works
Self-citationEnose‐Akahata, Y., Oh, U., Grant, C. W., & Jacobson, S. (2008) · Blood · doi:10.1182/blood-2008-02-138529 · Cited by 39 · see citing works
Self-citationNozuma, S., Kubota, R., & Jacobson, S. (2020) · Journal of NeuroVirology · doi:10.1007/s13365-020-00881-w · Cited by 41 · see citing works
Self-citationSaito, M. (2010) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2010/478461 · Cited by 35 · see citing works
Varrin‐Doyer, M., Nicolle, A., Marignier, R., Cavagna, S., Benetollo, C., Wattel, E., & Giraudon, P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101562 · Cited by 36 · see citing works
Immunophenotypic characterization of CSF B cells in virus-associated neuroinflammatory diseases
Enose‐Akahata, Y., Azodi, S., Smith, B., Billioux, B. J., Vellucci, A., Ngouth, N., Tanaka, Y., Ohayon, J. M., Cortese, I. C. M., Nath, A., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007042 · Cited by 36 · see citing works
Self-citationKuramitsu, M., Okuma, K., Yamagishi, M., Yamochi, T., Firouzi, S., Momose, H., Mizukami, T., Takizawa, K., Araki, K., Sugamura, K., et al. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.02254-14 · Cited by 35 · see citing works
Hofbauer, J. P., Kelly, S. M., Price, N. C., Flanagan, J. U., & Brighty, D. W. (2003) · Journal of Virology · doi:10.1128/jvi.77.5.3281-3290.2003 · Cited by 33 · see citing works
Nakamura, T. (2009) · PubMed · Cited by 32 · see citing works
Santos, S. B., Porto, A. F., Muniz, A. L., Luna, T., Nascimento, M., Guerreiro, J. B., Filho, J. O., Morgan, D. J., & Carvalho, E. M. (2006) · NeuroImmunoModulation · doi:10.1159/000097259 · Cited by 32 · see citing works
Enose‐Akahata, Y., Matsuura, E., Oh, U., & Jacobson, S. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000682 · Cited by 29 · see citing works
Self-citationEnose‐Akahata, Y., Matsuura, E., Tanaka, Y., Oh, U., & Jacobson, S. (2012) · Retrovirology · doi:10.1186/1742-4690-9-16 · Cited by 28 · see citing works
Self-citationKuo, C.-W. S., Mirsaliotis, A., & Brighty, D. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100070 · Cited by 27 · see citing works
NK cells and monocytes modulate primary HTLV-1 infection
Moles, R., Sarkis, S., Galli, V., Omsland, M., Artesi, M., Bissa, M., McKinnon, K. M., Brown, S., Hahaut, V., Washington‐Parks, R., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010416 · Cited by 26 · see citing works
Moens, B., Decanine, D., Menezes, S. M., Khouri, R., Silva-Santos, G., López, G., Álvarez, C., Talledo, M., Gotuzzo, E., Kruschewsky, R. D. A., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001729 · Cited by 25 · see citing works
Ahuja, J., Kampani, K., Datta, S., Wigdahl, B. L., Flaig, K. E., & Jain, P. (2006) · Journal of NeuroVirology · doi:10.1080/13550280600614981 · Cited by 25 · see citing works
HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues
Nakamura, T. (2023) · Pathogens · doi:10.3390/pathogens12030492 · Cited by 24 · see citing works
Kuramitsu, M., Okuma, K., Yamochi, T., Sato, T., Sasaki, D., Hasegawa, H., Umeki, K., Kubota, R., Sobata, R., Matsumoto, C., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.01628-15 · Cited by 24 · see citing works
Self-citationClinical trial of raltegravir, an integrase inhibitor, in HAM/TSP
Enose‐Akahata, Y., Billioux, B. J., Azodi, S., Dwyer, J. E., Vellucci, A., Ngouth, N., Nozuma, S., Massoud, R., Cortese, I. C. M., Ohayon, J. M., et al. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51437 · Cited by 23 · see citing works
Self-citationTakenouchi, N. (2004) · Frontiers in bioscience · doi:10.2741/1414 · Cited by 23 · see citing works
Otaguiri, K. K., dos Santos, D. F., Slavov, S. N., Depieri, L. V., Palma, P. V. B., Meirelles, F. V., Covas, D. T., da Silveira, J. C., & Kashima, S. H. (2018) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2018.0115 · Cited by 22 · see citing works
Current State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22 · see citing works
Kamihira, S., Yamano, Y., Iwanaga, M., Sasaki, D., Satake, M., Okayama, A., Umeki, K., Kubota, R., Izumo, S., Yamaguchi, K., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01720.x · Cited by 20 · see citing works
Self-citationThe Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
Amorim, C. F., Carvalho, N. B., Neto, J. A. C., Santos, S. B., Grassi, M. F. R., Carvalho, L. P., & Carvalho, E. M. (2019) · Journal of Immunology Research · doi:10.1155/2019/6574828 · Cited by 19 · see citing works
HTLV‐1 oncovirus‐host interactions: From entry to the manifestation of associated diseases
Ghezeldasht, S. A., Shamsian, S. A. A., Navashenaq, J. G., Miri, R., Ashrafi, F., Mosavat, A., & Rezaee, S. A. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2235 · Cited by 17 · see citing works
Sagar, D., Masih, S., Schell, T. D., Jacobson, S., Comber, J. D., Philip, R., Wigdahl, B. L., Jain, P., & Khan, Z. K. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.03.087 · Cited by 19 · see citing works
Self-citationInterferon-α significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP
Feng, J., Misu, T., Fujihara, K., Saito, H., Takahashi, T., Kohnosu, T., Shiga, Y., Takeda, A., Sato, S., Takase, S., et al. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00219-4 · Cited by 18 · see citing works
Saito, M. (2013) · Journal of NeuroVirology · doi:10.1007/s13365-013-0192-8 · Cited by 17 · see citing works
Maloney, E. M., Yamano, Y., VanVeldhuisen, P., Sawada, T., Kim, N., Cranston, B., Hanchard, B., Jacobson, S., & Hisada, M. (2006) · The Journal of Infectious Diseases · doi:10.1086/506365 · Cited by 18 · see citing works
Self-citationClinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP
Enose‐Akahata, Y., Oh, U., Ohayon, J. M., Billioux, B. J., Massoud, R., Bryant, B. R., Vellucci, A., Ngouth, N., Cortese, I. C. M., Waldmann, T. A., et al. (2019) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50820 · Cited by 17 · see citing works
Self-citationAdult T-cell leukemia: future prophylaxis and immunotherapy
Kannagi, M., Harashima, N., Kurihara, K., Utsunomiya, A., Tanosaki, R., & Masuda, M. (2004) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.4.3.369 · Cited by 17 · see citing works
Early-Onset HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
Schwalb, A., Pérez-Muto, V., Cachay, R., Tipismana, M., Álvarez, C., Mejía, F., González-Lagos, E., & Gotuzzo, E. (2020) · Pathogens · doi:10.3390/pathogens9060450 · Cited by 16 · see citing works
Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells
Johnson-Nauroth, J. M., Graber, J. J., Yao, K., Jacobson, S., & Calabresi, P. A. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.013 · Cited by 15 · see citing works
Self-citationAnalysis of a hepatitis B viral infection model with immune response delay
Pang, J., & Cui, J. (2016) · International Journal of Biomathematics · doi:10.1142/s1793524517500206 · Cited by 14 · see citing works
de Sá, K. S. G., Santana, B. B., Ferreira, T. C. D. S., Sousa, R. C. M., Caldas, C. A. M., Azevedo, V. N., Feitosa, R. N. M., Machado, L. F. A., Ishak, M. D. O. G., Ishak, R., et al. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.004 · Cited by 14 · see citing works
Gudo, E. S., Silva-Barbosa, S. D., Linhares‐Lacerda, L., Alves, M. R., Côrte‐Real, S., Bou‐Habib, D. C., & Savino, W. (2015) · Virology Journal · doi:10.1186/s12985-015-0398-x · Cited by 14 · see citing works
Tarokhian, H., Taghadosi, M., Rafatpanah, H., Rajaei, T., Azarpazhooh, M. R., Valizadeh, N., & Rezaee, S. A. (2016) · Virus Research · doi:10.1016/j.virusres.2016.11.009 · Cited by 14 · see citing works
Monocyte and Macrophage Functions in Oncogenic Viral Infections
Echevarria‐Lima, J., & Moles, R. (2024) · Viruses · doi:10.3390/v16101612 · Cited by 13 · see citing works
Martins, M. L., Carneiro‐Proietti, A. B. F., Nicolato, R., de Miranda, D. M., & Romanelli, L. C. F. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0632-6 · Cited by 13 · see citing works
Enose-Akahata, Y., Ngouth, N., Ohayon, J., Mandel, M., Chavin, J., Turner, T. J., & Jacobson, S. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000986 · Cited by 13 · see citing works
Self-citationQuantification of HTLV-I proviral load in experimentally infected rabbits
Zhao, T., Hague, B. F., Caudell, D. L., Simpson, R. J., & Kindt, T. J. (2005) · Retrovirology · doi:10.1186/1742-4690-2-34 · Cited by 13 · see citing works
Neurologic disease due to HTLV-1 infection
McKendall, R. R. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53488-0.00024-9 · Cited by 12 · see citing works
Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease
Nozuma, S., Matsuura, E., Tanaka, M., Kodama, D., Matsuzaki, T., Yoshimura, A., Sakiyama, Y., Nakahata, S., Morishita, K., Enose‐Akahata, Y., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.167422 · Cited by 12 · see citing works
Ghezeldasht, S. A., Mosavat, A., & Rezaee, S. A. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.2567 · Cited by 11 · see citing works
Mirsaliotis, A., Lamb, D., & Brighty, D. W. (2008) · Journal of Virology · doi:10.1128/jvi.02458-07 · Cited by 11 · see citing works
T cell receptor repertoire analysis in HTLV-1-associated diseases
Clauze, A., Enose‐Akahata, Y., & Jacobson, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.984274 · Cited by 10 · see citing works
Self-citationImmunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease
Nozuma, S., Enose‐Akahata, Y., Johnson, K. R., Monaco, M. C., Ngouth, N., ELKAHLOUN, A. G., Ohayon, J. M., Zhu, J., & Jacobson, S. (2021) · JCI Insight · doi:10.1172/jci.insight.144869 · Cited by 10 · see citing works
Self-citationNagai, M., Tsujii, T., Iwaki, H., Nishikawa, N., & Nomoto, M. (2013) · Internal Medicine · doi:10.2169/internalmedicine.52.0869 · Cited by 10 · see citing works
Self-citationGutowska, A., McKinnon, K. M., Sarkis, S., Doster, M. N., Bissa, M., Moles, R., Stamos, J. D., Rahman, M. A., Washington‐Parks, R., Davis, D. A., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.897264 · Cited by 9 · see citing works
- Authors
- Nagai, M., Yamano, Y., Brennan, M. B., Mora, C. A., & Jacobson, S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Jacobson, Steven
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-11-29
- Volume
- 50
- Issue
- 6
- Pages
- 807-812
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085122076
- Cited by
- 144
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- HTLV-1, HTLV-1-associated myelopathy/tropical spastic paraparesis, cerebrospinal fluid, proviral load, CD8+ T cells, HLA tetramers, cytomegalovirus-specific T cells, pathogenesis, neuroinflammation
- MeSH terms
- Adolescent, Adult, Cerebrospinal Fluid, Female, Flow Cytometry, Humans, Male, Middle Aged, Peptide Fragments, Human T-lymphotropic virus 1, Biomarkers, Paraparesis, Tropical Spastic, Gene Products, tax, CD8-Positive T-Lymphocytes, Viral Load
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