Cited by 144T-cell and Retrovirus StudiesHIV Research and TreatmentInfectious Diseases and Tuberculosis

Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP

Nagai, Masahiro, Yamano, Yoshihisa, Brennan, Meghan B., Mora, Carlos A., Jacobson, Steven·2001·Annals of Neurology

Abstract

To date, high human T‐cell lymphotropic virus type I proviral load in patients with human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related to the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis. However, the proviral load in cerebrospinal fluid has not been well investigated. We measured human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells from human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis patients using real‐time quantitative polymerase chain reaction (TaqMan). Human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells were significantly higher than that of the matched peripheral blood mononuclear cells, and a high ratio of human T‐cell lymphotropic virus type I proviral load in cerebrospinal fluid cells to peripheral blood mononuclear cells were observed in patients with short duration of illness. Human T‐cell lymphotropic virus type I Tax‐specific CD8+ T cells, as detected by peptide‐loaded HLA tetramers, accumulated in cerebrospinal fluid compared with that in peripheral blood mononuclear cells, while the frequency of cytomegalovirus‐specific CD8+ T cells in cerebrospinal fluid was reduced. These observations suggest that accumulation of both human T‐cell lymphotropic virus type I‐infected cells and preferential expansion of human T‐cell lymphotropic virus type I‐specific CD8+ cells in cerebrospinal fluid may play a role in the pathogenesis of human T‐cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis.

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Crossref · 10.1002/ana.10065

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  • Tax is associated with T cell transformation, resulting in activation and proliferation of infected cells and HTLV-1 leukaemogenesis.

    “It is associated with T cell transformation, resulting in the activation and proliferation of infected cells and HTLV-1 leukaemogenesis [46,68,215,216].”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]

  • Increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression.

    “There is strong evidence suggesting that increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression [216,271,272,273].”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [216]

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Authors
Nagai, M., Yamano, Y., Brennan, M. B., Mora, C. A., & Jacobson, S.
Affiliations
National Institutes of Health (US)
Corresponding author
Jacobson, Steven
Venue
Annals of Neurology
Publisher
Wiley
Published
2001-11-29
Volume
50
Issue
6
Pages
807-812
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2085122076
Cited by
144
References
24
Citations by year
2026: 1 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 5
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords
HTLV-1, HTLV-1-associated myelopathy/tropical spastic paraparesis, cerebrospinal fluid, proviral load, CD8+ T cells, HLA tetramers, cytomegalovirus-specific T cells, pathogenesis, neuroinflammation
MeSH terms
Adolescent, Adult, Cerebrospinal Fluid, Female, Flow Cytometry, Humans, Male, Middle Aged, Peptide Fragments, Human T-lymphotropic virus 1, Biomarkers, Paraparesis, Tropical Spastic, Gene Products, tax, CD8-Positive T-Lymphocytes, Viral Load

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