Increased HTLV‐I proviral DNA in HTLV‐I–associated myelopathy: A quantitative polymerase chain reaction study
Abstract
Using the polymerase chain reaction, we quantitated the amount of human T‐lymphotropic virus type I (HTLV‐I) proviral DNA in peripheral blood mononuclear cells from 18 patients with HTLV‐I–associated myelopathy/tropical spastic paraparesis; 17 HTLV‐I carriers without HTLV‐I–associated myelopathy/tropical spastic paraparesis, with or without other autoimmune or inflammatory diseases; and 19 seronegative control subjects. The HTLV‐I proviral DNA was 10‐ to 100‐fold higher in the patients and in the HTLV‐I carriers without HAM/TSP who had autoimmune or inflammatory diseases than in the carriers without autoimmune or inflammatory diseases. The patients who had had onset of myelopathy at a younger age (15 to 39 years) had an extremely high level of HTLV‐I proviral DNA in the early phase, as compared with findings in those with a late onset of myelopathy (at 44 to 61 years). The large increase in HTLV‐I proviral DNA in peripheral blood mononuclear cells is presumably closely related to the development of autoimmune or inflammatory processes in HTLV‐I carriers, including HTLV‐I–associated myelopathy/tropical spastic paraparesis.
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Increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression.
“There is strong evidence suggesting that increased HTLV-1 PVL in PBMCs is a potent risk factor for disease progression [216,271,272,273].”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [271]
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- Authors
- Kira, J., Koyanagi, Y., Yamada, T., Itoyama, Y., Goto, I., Yamamoto, N., Sasaki, H., & Sakaki, Y.
- Affiliations
- Kyushu University (JP)
- Yamaguchi University (JP)
- Corresponding author
- Kira, Jun‐ichi
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1991-02
- Volume
- 29
- Issue
- 2
- Pages
- 194-201
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2089048401
- Cited by
- 152
- References
- 41
- Citations by year
- 2024: 6 · 2023: 2 · 2022: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2013: 3 · 2012: 4
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- HTLV-1, proviral DNA, tropical spastic paraparesis, peripheral blood mononuclear cells, HTLV-1 carriers, autoimmune disease, inflammatory diseases, age of onset, viral load
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, DNA, Viral, Female, Humans, Leukocytes, Mononuclear, Male, Middle Aged, Human T-lymphotropic virus 1, Paraparesis, Tropical Spastic, Polymerase Chain Reaction
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