The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Adenosine: A potential mediator of seizure arrest and postictal refractoriness
Abstract
Adenosine is a potent inhibitory neuromodulator and has been proposed as an endogenous anticonvulsant. Depth electrodes modified to include a microdialysis probe were implanted for 10 to 16 days in the hippocampi of 4 patients with intractable complex partial epilepsy to test the hypothesis that during seizures extracellular adenosine reaches levels that may depress epileptiform activity. Samples were collected bilaterally at 3‐minute intervals before, during, and after a single, spontaneous‐onset seizure in each patient. All seizures commenced in one hippocampus and propagated to the contralateral hippocampus. Extracellular adenosine levels increased by 6‐ to 31‐fold with the increase significantly greater in the epileptogenic hippocampus. During seizures, levels of adenosine in the dialysate reached concentrations as high as 2.5 μM, reflecting extracellular concentrations of approximately 65 μM. Adenosine at concentrations of 40 to 50 μM depresses epileptiform activity in vitro, so the levels we report may suppress seizure activity in vivo. Moreover, adenosine levels remain elevated above basal values for the entire 18‐minute postical period. These data support the role of adenosine in mediating seizure arrest and postictal refractoriness and suggest that treatments which facilitate adenosine may be effective in preventing seizures.
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Cites
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Theophylline-Induced Seizures in Adults: Correlation with Serum Concentrations
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Is Adenosine an Endogenous Anticonvulsant?
Dragunow, M., Goddard, G. V., & Laverty, R. (1985) · Epilepsia · doi:10.1111/j.1528-1157.1985.tb05684.x · Cited by 245
Endogenously Released Adenosine Regulates Excitability in the In Vitro Hippocampus
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Cited by
The Role and Regulation of Adenosine in the Central Nervous System
Dunwiddie, T. V., & Masino, S. A. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.31 · Cited by 1,632
Devinsky, O., Cilio, M. R., Cross, H., Fernandez‐Ruiz, J., French, J., Hill, C., Katz, R., Di Marzo, V., Jutras‐Aswad, D., Notcutt, W. G., et al. (2014) · Epilepsia · doi:10.1111/epi.12631 · Cited by 1,000
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
Cunha, R. A. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-0649-1 · Cited by 537
Neuron–glia interactions in the pathophysiology of epilepsy
Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0126-4 · Cited by 462
How does adenosine control neuronal dysfunction and neurodegeneration?
Cunha, R. A. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13724 · Cited by 441
Metadata
- Authors
- During, M. J., & Spencer, D. D.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1992-11
- Volume
- 32
- Issue
- 5
- Pages
- 618-624
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2033456548
- Cited by
- 476
- References
- 30
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- During, M. J., & Spencer, D. D. (1992). Adenosine: A potential mediator of seizure arrest and postictal refractoriness. Annals of Neurology. https://doi.org/10.1002/ana.410320504
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
