The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Pathological markers associated with normal aging and dementia in the elderly
Abstract
We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median age of both groups, 88 years) who had been studied prospectively for 4.0 ± 2.1 years. Very old demented subjects almost always had nonneuritic senile plaques, but over half had no neuritic senile plaques and little other AD pathology. Five subjects had cortical Lewy bodies; all were demented. We propose that hippocampal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia. When grouped together, these markers were significantly associated with dementia and occurred in 40% of demented subjects. As the relative frequency of neuritic markers of AD (and possibly AD itself) declines in the tenth decade, vascular dementia may become an increasingly important type of dementia.
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“In contrast to the increased prevalence of clinical dementia with advanced age, the prevalence of cases with high NP and high NFT pathologic diagnosis at autopsy seems to level off in the oldest old according to multiple autopsy series (154, 168-172).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
In the citing paper
“Thus, in the oldest old, the prevalence of concomitant non-AD brain diseases, including CVD and hippocampal sclerosis, begins to mimic the effects of AD pathologic diagnosis (154, 221, 222).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
In the citing paper
“Numerous CPC studies have assessed the association between NFTs and cognitive status (38, 98, 154, 158, 162, 185, 188, 189, 191, 223-232, 235-240, 244, 250-252, 258, 261, 264, 287-296).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [154]
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Cites
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643
Self-citationCrystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586
Self-citationSenile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 575
Morris, J. C., McKeel, D. W., Storandt, M., Rubin, E. H., Price, J. L., Grant, E. A., Ball, M. J., & Berg, L. (1991) · Neurology · doi:10.1212/wnl.41.4.469 · Cited by 473
Research works printed but not linked: 4
- Crystal H, 1992, Does Alzheimer's disease cause most cases of dementia in the oldest‐old?, Neurology, 42, 358
- Lipton R, 1992, Clinical and pathologic diagnosis of Alzheimer's disease in the oldest‐old, Neurology, 42, 358
- Masur D, 1992, Association of neuropathology with patterns of neuropsychological decline in elderly subjects, Neurology, 42, 359
- Knopman DS, 1988, Dementia lacking distinctive histologic features: a common non‐Alzheimer degenerative dementia, Neurology, 47, 536
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Gómez‐Tortosa, E., Ingraham, A. O., Irizarry, M. C., & Hyman, B. T. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb06016.x · Cited by 44
Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia
Burton, E. J., Mukaetova-Ladinska, E. B., Perry, R. H., Jaros, E., Barber, R., & O'Brien, J. T. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.12.015 · Cited by 43
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Abner, E. L., Neltner, J. H., Jicha, G. A., Patel, E., Anderson, S., Wilcock, D. M., Eldik, L. J. V., & Nelson, P. T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180514 · Cited by 42
Dugger, B. N., Serrano, G. E., Sue, L. I., Walker, D. G., Adler, C. H., Shill, H. A., Sabbagh, M. N., Caviness, J. N., Hidalgo, J., Saxon‐LaBelle, M., et al. (2012) · Journal of Parkinson s Disease · doi:10.3233/jpd-2012-11073 · Cited by 42
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Kaur, B., Himali, J. J., Seshadri, S. S., Beiser, A., Au, R., McKee, A. C., Auerbach, S. H., Wolf, P. A., & DeCarli, C. S. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000032 · Cited by 35
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Beach, T. G. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac030 · Cited by 37
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Lathe, R., & Clair, D. S. (2023) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12959 · Cited by 37
Patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.
Richards, B., Chertkow, H., Singh, V., Robillard, A., Massoud, F., Evans, A., & Kabani, N. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.019 · Cited by 43
Reduced Temporal Lobe Glucose Metabolism in Aging
Eberling, J. L., NORDAHL, T. E., Kusubov, N., Reed, B., Budinger, T. F., & Jagust, W. J. (1995) · Journal of Neuroimaging · doi:10.1111/jon199553178 · Cited by 33
Azarpazhooh, M. R., Avan, A., Cipriano, L. E., Munoz, D. G., Erfanian, M., Amiri, A., Stranges, S., & Hachinski, V. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.101002 · Cited by 32
Robinson, A., Davidson, Y. S., Horan, M. A., Pendleton, N., & Mann, D. M. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180171 · Cited by 29
Schochet, S. S. (1998) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70081-5 · Cited by 31
Forgetting in Dementia With and Without Subcortical Lacunes
Kramer, J. H., Mungas, D., Reed, B., Schuff, N. W., Weiner, M. W., Miller, B. L., & Chui, H. C. (2004) · The Clinical Neuropsychologist · doi:10.1080/13854040490507136 · Cited by 30
Anti-RAGE and A Immunoglobulin Levels Are Related to Dementia Level and Cognitive Performance
Wilson, J. S., Mruthinti, S., Buccafusco, J. J., Schade, R., Mitchell, M. B., Harrell, D., Gulati, N. K., & Miller, L. S. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln002 · Cited by 31
Panza, F., Frisardi, V., Capurso, C. A., D’Introno, A., Colacicco, A. M., Palo, A. D., Imbimbo, B. P., Vendemiale, G., Capurso, A., & Solfrizzi, V. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.48 · Cited by 27
Montine, T. J., Quinn, J. F., Montine, K. S., Kaye, J. A., & Breitner, J. C. S. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8405 · Cited by 23
Crystal, H., Dickson, D. W., Sliwinski, M. J., Masur, D., Blau, A. D., & Lipton, R. B. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550010102023 · Cited by 23
Self-citationProposals for Re-evaluation of Current Autopsy Criteria for the Diagnosis of Alzheimer’s Disease
Jellinger, K. A., & Bancher, C. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00071-7 · Cited by 23
Age, education and dementia related deaths. The Norwegian Counties Study and The Cohort of Norway
Strand, B. H., Langballe, E. M., Rosness, T. A., Bergem, A. L. M., Engedal, K., Nafstad, P. H. J., Tell, G. S., Ormstad, H., Tambs, K., & Bjertness, E. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.07.009 · Cited by 22
Biomarkers for Alzheimer’s disease
Sonnen, J. A., Keene, C. D., Montine, K. S., Li, G., Peskind, E. R., Zhang, J., & Montine, T. J. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.8.1021 · Cited by 18
Carlos, A. F., & Josephs, K. A. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11073-3 · Cited by 18
Pathological Lesions in Vascular Dementia
Pantoni, L., Palumbo, V., & Sarti, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04827.x · Cited by 16
Neuropathologic Changes of Alzheimer’s Disease and Related Dementias: Relevance to Future Prevention
White, L. R., Corrada, M. M., Kawas, C. H., Cholerton, B., Edland, S. E., Flanagan, M. E., & Montine, T. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230331 · Cited by 13
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Baba, Y., Putzke, J. D., Tsuboi, Y., Josephs, K. A., Thomas, N., Wszołek, Z. K., & Dickson, D. W. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.032 · Cited by 12
Self-citationRobinson, A., McNamee, R., Davidson, Y. S., Horan, M. A., Snowden, J. S., McInnes, L., Pendleton, N., & Mann, D. M. A. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000486827 · Cited by 11
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Román, G. C., & Benavente, O. (2004) · Seminars in Cerebrovascular Diseases and Stroke · doi:10.1053/j.scds.2004.10.002 · Cited by 11
Vascular cognitive impairment: dementia biology and translational animal models.
Barone, F. C., Rosenbaum, D. M., Zhou, J., & Crystal, H. (2009) · PubMed · Cited by 11
Self-citationJellinger, K. A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00048-1 · Cited by 11
Classification of dementias based on functional morphology
Jellinger, K. A., & Bancher, C. (1994) · Key topics in brain research · doi:10.1007/978-3-7091-9376-1_2 · Cited by 10
Datasets for Special Series on Cognitive Reserve
Bennett, D. A., & Barnes, L. L. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000622 · Cited by 10
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Butler, C., & Ahmed, S. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.016 · Cited by 6
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Morris, J. C. (1995) · Elsevier eBooks · doi:10.1016/b978-012286965-5/50013-3 · Cited by 6
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Mohr, J. P. (1998) · Annals of Neurology · doi:10.1002/ana.410440503 · Cited by 6
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Mast, H., & Mohr, J. P. (2004) · Elsevier eBooks · doi:10.1016/b0-44-306600-0/50037-7 · Cited by 5
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Jeong, J. H., Kim, E., Seo, S. W., & Na, D. L. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139924771.020 · Cited by 3
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Quinn, J. F., Morrow, J. D., Montine, T. J., & Kaye, J. A. (2005) · Oxidative stress and disease · doi:10.1201/9781420026559.ch8 · Cited by 3
Cognitive and behavioral abnormalities of vascular dementia
Jeong, J. H., Kim, E., Seo, S. W., & Na, D. L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511581410.021 · Cited by 2
Dementia associated with cortical dysplasia
Bigio, E. H., Fontaine, C. S., Dababo, M. A., Prahlow, J. A., Chason, D. P., Weiner, M., & White, C. L. (1998) · Acta Neuropathologica · doi:10.1007/s004010050786 · Cited by 2
Forstmeier, S., & Maercker, A. R. A. (2009) · Zeitschrift für Neuropsychologie · doi:10.1024/1016-264x.20.1.47 · Cited by 2
Anderson, N. H., & Woodburn, K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-7020-3137-3.00022-x · Cited by 1
Current Diagnostic Criteria for Assessment of Neuropathological Alzheimer’s Disease
Gambetti, P. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00060-2 · Cited by 1
Neltner, J. H., & Nelson, P. T. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch1 · Cited by 1
Grinberg, L. T. (2006) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2006.tde-04042007-082907
Opii, W. O. (2006) · UKnowledge (University of Kentucky)
Chapter 3 Structural Changes in the Aged Brain
Dickson, D. W. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60053-x
Self-citationMan with post-operative cognitive impairment
Román, G. C., & Bazán, C. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511997433.023
Paulo, S. (2006)
Okello, A. (2011) · Spiral (Imperial College London) · doi:10.25560/7110
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Kim, G. H., Hwang, J., & Jeong, J. H. (2020) · Stroke revisited · doi:10.1007/978-981-10-1433-8_9
Mackie, E. C., Cheng, C.-H., Alibrio, M. N., Rutledge, C., Xin, H., Chopp, M., McCann, R., Rosene, D. L., Yang, Q., Zeldich, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.14.623673
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Nascimento, C. F. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2015.tde-18062015-114710
- Self-citation
Metadata
- Authors
- Crystal, H. A., Dickson, D. W., Sliwinski, M. J., Lipton, R. B., Grober, E., Marks‐Nelson, H., & Antis, P.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Crystal, Howard A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1993-10
- Volume
- 34
- Issue
- 4
- Pages
- 566-573
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2163665026
- Cited by
- 161
- References
- 37
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 9
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-O3949)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, dementia with Lewy bodies, vascular dementia, normal aging, dementia, cortical Lewy bodies, hippocampal sclerosis, leukoencephalopathy, cognitive function, older adults, pathological markers
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cerebral Infarction, Dementia, Female, Hippocampus, Humans, Male, Dementia, Vascular, Lewy Bodies, Neurofibrillary Tangles
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