The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Parkinson's disease and brain levels of organochlorine pesticides
Abstract
Epidemiological studies have suggested an etiologic relationship between pesticide exposure and Parkinson's disease (PD). Organochlorine pesticides were assayed in postmortem brain samples from 20 PD, 7 Alzheimer's disease (AD), and 14 nonneurological control cases. The three groups were similar in age at death, sex, and demographic variables. Only two of 16 pesticide residues screened were detected. A long‐lasting residue of DDT (pp‐DDE) was found in the majority of cases of PD and AD, as well as in all the control cases; pp‐DDT was significantly more likely to be found in AD controls than the PD cases (Fisher's exact two‐tailed, p = 0.04). Dieldrin was detected in 6 of 20 PD brains, 1 of 7 AD, and in none of 14 control samples. Despite the relatively small number of brains assayed, the association between Dieldrin and the diagnosis of PD was highly significant (p = 0.03). Dieldrin, a lipid‐soluble, long‐lasting mitochondrial poison, should be investigated as a potential etiological agent of Parkinsonism.
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Cites
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961
Cited by
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Wirdefeldt, K., Adami, H.-O., Cole, P., Trichopoulos, D., & Mandel, J. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9581-6 · Cited by 1,199
Epidemiology of parkinson’s disease
Tanner, C. M., & Goldman, S. M. (1996) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70259-0 · Cited by 640
Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598
Early Environmental Origins of Neurodegenerative Disease in Later Life
Landrigan, P. J., Sonawane, B., Butler, R. N., Trasande, L., Callan, R., & Droller, D. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7571 · Cited by 357
Potential occupational risks for neurodegenerative diseases
Park, R. M., Schulte, P. A., Bowman, J. D., Walker, J. T., Bondy, S. C., Yost, M. G., Touchstone, J. A., & Dosemeci, M. (2005) · American Journal of Industrial Medicine · doi:10.1002/ajim.20178 · Cited by 256
Metadata
- Authors
- Fleming, L., Mann, J. B., Bean, J., Briggle, T., & Sanchez‐Ramos, J. R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1994-07
- Volume
- 36
- Issue
- 1
- Pages
- 100-103
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2159728608
- Cited by
- 352
- References
- 1
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Parkinson's disease and brain levels of organochlorine pesticides. https://app.cochat.ai/papers/10.1002/ana.410360119
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- Fleming, L., Mann, J. B., Bean, J., Briggle, T., & Sanchez‐Ramos, J. R. (1994). Parkinson's disease and brain levels of organochlorine pesticides. Annals of Neurology. https://doi.org/10.1002/ana.410360119
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
