The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy
Abstract
Gabapentin has come into clinical use as adjunctive therapy in the treatment of epilepsy. Designed to mimic gammaaminobutyric acid (GABA), its mechanism of action remains elusive. In vivo measurements of GABA in human brain were made using 1 H magnetic resonance spectroscopy. We used a 2.1‐T magnetic resonance imager‐spectrometer and an 8‐cm surface coil to measure a 13.5‐cm 3 volume in the occipital cortex. GABA levels were measured in 14 patients enrolled in an open‐label trial of gabapentin. GABA was elevated in patients taking gabapentin compared with 14 complex partial epilepsy patients, matched for antiepileptic drug treatment. Brain GABA levels appeared to be higher in patients taking high‐dose gabapentin (3,300–3,600 mg/day) than in those taking standard doses (1,200–2,400 mg/ day). Gabapentin appears to increase human brain GABA levels.
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Cited by
Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553
A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders
Frye, M. A., Ketter, T. A., Kimbrell, T. A., Dunn, R. T., Speer, A. M., Osuch, E. A., Luckenbaugh, D. A., Corá-Locatelli, G., Leverich, G. S., & Post, R. M. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200012000-00004 · Cited by 446
Update on the Mechanism of Action of Antiepileptic Drugs
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A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal
Myrick, H., Malcolm, R., Randall, P. K., Boyle, E., Anton, R. F., Becker, H. C., & Randall, C. L. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00986.x · Cited by 201
Cai, K., Nanga, R. P., Lamprou, L., Schinstine, C., Elliott, M., Hariharan, H., Reddy, R., & Epperson, C. N. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.142 · Cited by 128
Metadata
- Authors
- Petroff, O. A. C., Rothman, D. L., Behar, K. L., Lamoureux, D., & Mattson, R. H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 39
- Issue
- 1
- Pages
- 95-99
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2116471965
- Cited by
- 285
- References
- 1
- FWCI
- 23.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. https://app.cochat.ai/papers/10.1002/ana.410390114
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- Petroff, O. A. C., Rothman, D. L., Behar, K. L., Lamoureux, D., & Mattson, R. H. (1996). The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy. Annals of Neurology. https://doi.org/10.1002/ana.410390114
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
