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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease

Weeks, R. A., Piccini, P., Harding, A. E., Brooks, D. J.·1996·Annals of Neurology
DOI 10.1002/ana.410400110
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Abstract

We have investigated striatal dopamine D1 and D2 receptor binding in asymptomatic subjects from Huntington's disease (HD) families using positron emission tomography. Nineteen adult subjects at risk of developing HD were scanned with 11 C‐SCH 23390 and 11 C‐raclopride to calculate the D1 and D2 receptor binding potential, respectively. Eight of the 19 were shown to have the HD mutation; of these, 4 subjects had significant reductions in striatal dopamine receptor binding. Abnormalities were more common in older subjects and were not correlated with the size of the HD mutation. There was a strong coefficient of correlation between individual levels of striatal D1 and D2 binding in subjects with the mutation. Of 6 other cases with a 50% risk of carrying the HD gene, 1 showed subclinical loss of caudate and putamen D2 binding. Our study suggests that both striatal D1 and D2 dopamine receptors are lost in parallel from both cauudate and putamen in presymptomatic HD and that dopamine receptor binding provides a sensitive means of detecting subclinical striatal dysfunction.

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  • The Drd2-eGFP colony is a transgenic mouse line generated in 2003 by GENSAT, with primary labelling in Drd2 positive medium spiny neurons from the indirect basal ganglia pathway.

    “The Drd2-eGFP colony is a transgenic mouse line generated in 2003 by the GENSAT (Gene Expression Nervous System Atlas) project at Rockefeller University in New York 60 .Primary labelling was found to occur in Drd2 positive medium spiny neurons from the indirect basal ganglia pathway.”

    From SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington’s disease phenotypes (2021) · cites this paper as [60]

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Research works printed but not linked: 29

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Metadata

Authors
Weeks, R. A., Piccini, P., Harding, A. E., & Brooks, D. J.
Venue
Annals of Neurology
Publisher
Wiley
Published
1996-07
Volume
40
Issue
1
Pages
49-54
ISSN
  • 0364-5134
  • 1531-8249
DOI
10.1002/ana.410400110
Cited by
166
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3021 d)

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