Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
Open accessAbstract
Background Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to identify sensitive and reliable biomarkers in premanifest carriers of mutated HTT and in individuals with early HD that could provide essential methodology for the assessment of therapeutic interventions.Methods This multicentre study uses an extensive battery of novel assessments, including multi-site 3T MRI, clinical, cognitive, quantitative motor, oculomotor, and neuropsychiatric measures. Blinded analyses were done on the baseline cross-sectional data from 366 individuals: 123 controls, 120 premanifest (pre-HD) individuals, and 123 patients with early HD.Findings The first participant was enrolled in January, 2008, and all assessments were completed by August, 2008. Cross-sectional analyses identified significant changes in whole-brain volume, regional grey and white matter differences, impairment in a range of voluntary neurophysiological motor, and oculomotor tasks, and cognitive and neuropsychiatric dysfunction in premanifest HD gene carriers with normal motor scores through to early clinical stage 2 disease.Interpretation We show the feasibility of rapid data acquisition and the use of multi-site 3T MRI and neurophysiological motor measures in a large multicentre study. Our results provide evidence for quantifiable biological and clinical alterations in HTT expansion carriers compared with age-matched controls. Many parameters differ from age-matched controls in a graded fashion and show changes of increasing magnitude across our cohort, who range from about 16 years from predicted disease diagnosis to early HD. These findings might help to define novel quantifiable endpoints and methods for rapid and reliable data acquisition, which could aid the design of therapeutic trials.
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The findings are consistent with prior studies suggesting that physiologic changes may be detectable before behavioral changes become manifest in a variety of neurological and neurodevelopmental disorders.
“Our findings are consistent with prior studies suggesting that physiologic changes may be detectable before behavioral changes become manifest in a variety of neurological and neurodevelopmental disorders [36–43].”
From EEG power at 3 months in infants at high familial risk for autism (2017) · cites this paper as [38]
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Cites
MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366 · see citing works
Unified Huntington's disease rating scale: Reliability and consistency
Kremer, H. P. H. (1996) · Movement Disorders · doi:10.1002/mds.870110204 · Cited by 2,109 · see citing works
Fischl, B. R., Liu, A., & Dale, A. M. (2001) · IEEE Transactions on Medical Imaging · doi:10.1109/42.906426 · Cited by 1,755 · see citing works
Look away: the anti-saccade task and the voluntary control of eye movement
Munoz, D. P., & Everling, S. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1345 · Cited by 1,423 · see citing works
Trinucleotide repeat length instability and age of onset in Huntington's disease
Duyao, M., Ambrose, C., Myers, R., Novelletto, A., Persichetti, F., Frontali, M., Folstein, S., Ross, C., Franz, M., Abbott, M., et al. (1993) · Nature Genetics · doi:10.1038/ng0893-387 · Cited by 1,089 · see citing works
Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease
Yamamoto, A., Lucas, J. J., & Hen, R. (2000) · Cell · doi:10.1016/s0092-8674(00)80623-6 · Cited by 1,068 · see citing works
Unified Huntington's disease rating scale: reliability and consistency
Kremer, H. P. H. (1996) · Radboud Repository (Radboud University) · Cited by 1,059 · see citing works
Regional and progressive thinning of the cortical ribbon in Huntington’s disease
Rosas, H. D., Liu, A. K., Hersch, S., Glessner, M., Ferrante, R. J., Salat, D. H., van der Kouwe, A., Jenkins, B. G., Dale, A. M., & Fischl, B. (2002) · Neurology · doi:10.1212/wnl.58.5.695 · Cited by 1,044 · see citing works
Self-citationLangbehn, D. R., Brinkman, R. R., Falush, D., Paulsen, J. S., Hayden, M. R., & on behalf of an International Huntington's Disease Collaborative Group (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00241.x · Cited by 820 · see citing works
Self-citationDetection of Huntington's disease decades before diagnosis: the Predict-HD study
Paulsen, J. S., Langbehn, D. R., Stout, J. C., Aylward, E., Ross, C. A., NANCE, M. A., Guttman, M., Johnson, S., MacDonald, M. E., Beglinger, L. J., et al. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.128728 · Cited by 808 · see citing works
Self-citationHuntington disease: Clinical care and evaluation
Shoulson, I., & Fahn, S. (1979) · Neurology · doi:10.1212/wnl.29.1.1 · Cited by 746 · see citing works
CAG repeat number governs the development rate of pathology in Huntington's disease
Penney, J. B., Vonsattel, J., MacDonald, M. E., Gusella, J. F., & Myers, R. H. (1997) · Annals of Neurology · doi:10.1002/ana.410410521 · Cited by 670 · see citing works
Stipe, J., White, D., & Arsdale, E. V. (1979) · AJN American Journal of Nursing · doi:10.2307/3424618 · Cited by 602 · see citing works
Onset and rate of striatal atrophy in preclinical Huntington disease
Aylward, E., Sparks, B. F., Field, K. M., Yallapragada, V., Shpritz, B., Rosenblatt, A., Brandt, J., Gourley, L. M., Liang, K., Zhou, H., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000132965.14653.d1 · Cited by 400 · see citing works
Behavioral changes in Huntington Disease.
Craufurd, D., Thompson, J. C., & Snowden, J. S. (2001) · PubMed · Cited by 385 · see citing works
Self-citationRate of functional decline in Huntington’s disease
Marder, K., Zhao, H., Myers, R. H., Cudkowicz, M., Kayson, E., Kieburtz, K., Orme, C., Paulsen, J., Penney, J. B., Siemers, E., et al. (2000) · Neurology · doi:10.1212/wnl.54.2.452 · Cited by 362 · see citing works
Motor disorder in Huntington's disease begins as a dysfunction in error feedback control
Smith, M. A., Brandt, J., & Shadmehr, R. (2000) · Nature · doi:10.1038/35000576 · Cited by 352 · see citing works
Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
Rosas, H. D., Hevelone, N. D., Zaleta, A. K., Greve, D. N., Salat, D. H., & Fischl, B. R. (2005) · Neurology · doi:10.1212/01.wnl.0000174432.87383.87 · Cited by 310 · see citing works
Self-citationStructural MR image processing using the brains2 toolbox
Magnotta, V. A., Harris, G., Andreasen, N. C., OʼLeary, D. S., Yuh, W. T. C., & Heckel, D. (2002) · Computerized Medical Imaging and Graphics · doi:10.1016/s0895-6111(02)00011-3 · Cited by 301 · see citing works
Preparing for Preventive Clinical Trials
Paulsen, J. S. (2006) · Archives of Neurology · doi:10.1001/archneur.63.6.883 · Cited by 292 · see citing works
Ciarmiello, A., Cannella, M., Lastoria, S., Simonelli, M., Frati, L., Rubinsztein, D. C., & Squitieri, F. (2006) · PubMed · Cited by 292 · see citing works
Interactive algorithms for the segmentation and quantitation of 3-D MRI brain scans
Freeborough, P. A., Fox, N. C., & Kitney, R. I. (1997) · Computer Methods and Programs in Biomedicine · doi:10.1016/s0169-2607(97)01803-8 · Cited by 276 · see citing works
Self-citationThe distribution of structural neuropathology in pre-clinical Huntington's disease
Thieben, M. J. (2002) · Brain · doi:10.1093/brain/awf179 · Cited by 270 · see citing works
Brain Structure in Preclinical Huntington’s Disease
Paulsen, J. S., Magnotta, V. A., Mikos, A., Paulson, H. L., Penziner, E., Andreasen, N. C., & Nopoulos, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.003 · Cited by 235 · see citing works
Psychiatric disorders in preclinical Huntington's disease
Julien, C. L., Thompson, J. C., Wild, S., Yardumian, P., Snowden, J. S., Turner, G., & Craufurd, D. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.103309 · Cited by 219 · see citing works
Self-citationStriatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease
Weeks, R. A., Piccini, P. P., Harding, A. E., & Brooks, D. J. (1996) · Annals of Neurology · doi:10.1002/ana.410400110 · Cited by 207 · see citing works
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
Johnson, H. J., Stout, J. C., Solomon, A. C., Langbehn, D. R., Aylward, E., Cruce, C. B., Ross, C. A., NANCE, M. A., Kayson, E., Julian-Baros, E., et al. (2007) · Brain · doi:10.1093/brain/awm107 · Cited by 195 · see citing works
Self-citationKlöppel, S., Draganski, B., Golding, C. V. P., Chu, C., Nagy, Z., Cook, P. A., Hicks, S. L., Christopher Kennard, C., Alexander, D. C., Parker, G. J. M., et al. (2007) · Brain · doi:10.1093/brain/awm275 · Cited by 171 · see citing works
Self-citationWolf, R. C., Vasić, N., Schönfeldt‐Lecuona, C., Landwehrmeyer, G. B., & Ecker, D. (2007) · Brain · doi:10.1093/brain/awm210 · Cited by 138 · see citing works
Subtle changes among presymptomatic carriers of the Huntington's disease gene
Kirkwood, S. C. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.6.773 · Cited by 136 · see citing works
Spectrum of gait impairments in presymptomatic and symptomatic Huntington's disease
Rao, A. K., Muratori, L. M., Louis, E. D., Moskowitz, C. B., & Marder, K. S. (2008) · Movement Disorders · doi:10.1002/mds.21987 · Cited by 130 · see citing works
Clinical correlation of striatal 1H MRS changes in Huntington’s disease
Sánchez‐Pernaute, R., García-Segura, J. M., Alba, A. D. B., Viano, J. C., & de Yébenes, J. G. (1999) · Neurology · doi:10.1212/wnl.53.4.806 · Cited by 113 · see citing works
fMRI detection of early neural dysfunction in preclinical Huntington's disease
Zimbelman, J. L., Paulsen, J. S., Mikos, A., Reynolds, N. C., Hoffmann, R. G., & Rao, S. M. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707071214 · Cited by 111 · see citing works
Defective emotion recognition in early HD is neuropsychologically and anatomically generic
Henley, S. M. D., Wild, E. J., Hobbs, N. Z., Warren, J. D., Frost, C. D., Scahill, R. I., Ridgway, G. R., MacManus, D. G., Barker, R. A., Fox, N. C., et al. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.02.025 · Cited by 100 · see citing works
Self-citationCoordination of Prehensile Forces during Precision Grip in Huntington's Disease
Gordon, A. M., Quinn, L., Reilmann, R., & Marder, K. S. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7348 · Cited by 96 · see citing works
Self-citationBerríos, G. E., Wagle, A. C., Marková, I. S., Wagle, S. A., Rosser, A., & Hodges, J. R. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.0o456.x · Cited by 94 · see citing works
Identification of an oculomotor biomarker of preclinical Huntington disease
Golding, C. V. P., Danchaivijitr, C., Hodgson, T. L., Tabrizi, S. J., & Christopher Kennard, C. (2006) · Neurology · doi:10.1212/01.wnl.0000218215.43328.88 · Cited by 88 · see citing works
Self-citationWhole‐brain atrophy as a measure of progression in premanifest and early Huntington's disease
Henley, S. M. D., Wild, E. J., Hobbs, N. Z., Frost, C. D., MacManus, D. G., Barker, R. A., Fox, N. C., & Tabrizi, S. J. (2009) · Movement Disorders · doi:10.1002/mds.22485 · Cited by 54 · see citing works
Self-citationOculomotor deficits indicate the progression of Huntington's Disease
Hicks, S. L., Robert, M. P. A., Golding, C. V. P., Tabrizi, S. J., & Christopher Kennard, C. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00678-x · Cited by 45 · see citing works
Self-citationReilmann, R., Kirsten, F., Bohlen, S. C., et al. (2005) · Max Planck Institute for Plasma Physics · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [40]Tibben A Bates GP Harper PS Jones L Genetic counselling and presymptomatic testing Huntington‘s disease 2002 Oxford Oxford Medical Publishers 198 250
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The connectomics of brain disorders
Fornito, A., Zalesky, A., & Breakspear, M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3901 · Cited by 1,734 · see citing works
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., Nance, M., Ross, C. A., Scahill, R. I., Wetzel, R., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.5 · Cited by 1,641 · see citing works
Self-citationTargeting Huntingtin Expression in Patients with Huntington’s Disease
Tabrizi, S. J., Leavitt, B. R., Landwehrmeyer, G. B., Wild, E. J., Saft, C., Barker, R. A., Blair, N. F., Craufurd, D., Priller, J., Rickards, H., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900907 · Cited by 708 · see citing works
Self-citationRohrer, J. D., Nicholas, J. M., Cash, D. M., van Swieten, J., Dopper, E., Jiskoot, L., van Minkelen, R., Rombouts, S. A., Cardoso, M. J., Clegg, S., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70324-2 · Cited by 538 · see citing works
Self-citationHazlett, H. C., Poe, M. D., Gerig, G., Styner, M., Chappell, C., Smith, R. G., Vachet, C., & Piven, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.39 · Cited by 481 · see citing works
Byrne, L. M., Rodrigues, F. B., Blennow, K., Durr, A., Leavitt, B. R., Roos, R. A. C., Scahill, R. I., Tabrizi, S. J., Zetterberg, H., Langbehn, D., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30124-2 · Cited by 364 · see citing works
Self-citationMoss, D. J. H., Pardiñas, A. F., Langbehn, D., Lo, K., Leavitt, B. R., Roos, R., Durr, A., Mead, S., Coleman, A., Santos, R. D., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30161-8 · Cited by 312 · see citing works
Self-citationHohenfeld, C., Werner, C. J., & Reetz, K. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.03.013 · Cited by 232 · see citing works
Jiang, R., Diaz-Castro, B., Looger, L. L., & Khakh, B. S. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3693-15.2016 · Cited by 237 · see citing works
Politis, M., Pavese, N., Tai, Y. F., Kiferle, L., Mason, S. L., Brooks, D. J., Tabrizi, S. J., Barker, R. A., & Piccini, P. (2011) · Human Brain Mapping · doi:10.1002/hbm.21008 · Cited by 212 · see citing works
Self-citationWasser, C. I., Mercieca, E.-C., Kong, G., Hannan, A. J., McKeown, S. J., Glikmann-Johnston, Y., & Stout, J. C. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa110 · Cited by 198 · see citing works
Self-citationHuntington disease: A single-gene degenerative disorder of the striatum
Nopoulos, P. C. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/pnopoulos · Cited by 161 · see citing works
Biological and clinical manifestations of juvenile Huntington’s disease: A retrospective analysis
Fusilli, C., Migliore, S., Mazza, T., Consoli, F., De Luca, A., Barbagallo, G., Ciammola, A., Gatto, E. M., Cesarini, M., Etcheverry, J. L., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30294-1 · Cited by 148 · see citing works
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Novak, M. J. U., & Tabrizi, S. J. (2011) · International Review of Neurobiology · doi:10.1016/b978-0-12-381328-2.00013-4 · Cited by 137 · see citing works
Self-citationBirba, A., García-Cordero, I., Kozono, G., Legaz, A., Ibáñez, A., Sedeño, L., & García, A. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.011 · Cited by 128 · see citing works
Novel Methods and Technologies for 21st-Century Clinical Trials: A Review
Dorsey, E. R., Venuto, C., Venkataraman, V., Harris, D. A., & Kieburtz, K. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4524 · Cited by 118 · see citing works
(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63233-3.00017-8 · Cited by 122 · see citing works
Self-citationEEG power at 3 months in infants at high familial risk for autism
Levin, A. R., Varcin, K. J., O’Leary, H. M., Tager-Flusberg, H., & Nelson, C. A. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9214-9 · Cited by 107 · see citing works
Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91 · see citing works
Feigin, A., Evans, E. E., Fisher, T. L., Leonard, J. E., Smith, E. S., Reader, A., Mishra, V., Manber, R., Walters, K. A., Kowarski, L., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01919-8 · Cited by 67 · see citing works
Self-citationStriatal atrophy and dendritic alterations in a knock-in mouse model of Huntington's disease
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Faster perceptual learning through excitotoxic neurodegeneration
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Thorley, E. M., Iyer, R. G., Wicks, P., Curran, C., Gandhi, S. K., Abler, V., Anderson, K. E., & Carlozzi, N. E. (2018) · The Patient - Patient-Centered Outcomes Research · doi:10.1007/s40271-018-0312-x · Cited by 32 · see citing works
Ranganathan, M., Kostyk, S. K., Allain, D. C., Race, J. A., & Daley, A. M. (2021) · Clinical Genetics · doi:10.1111/cge.13857 · Cited by 20 · see citing works
Fisher, E. R., Rocha, N. P., Morales-Scheihing, D. A., Venna, V. R., Furr-Stimming, E. E., Teixeira, A. L., & Rossetti, M. A. (2021) · Journal of Huntington's disease · doi:10.3233/jhd-210467 · Cited by 8 · see citing works
- Authors
- Tabrizi, S. J., Langbehn, D. R., Leavitt, B. R., Roos, R. A., Durr, A., Craufurd, D., Kennard, C., Hicks, S. L., Fox, N. C., Scahill, R. I., Borowsky, B., Tobin, A. J., Rosas, H. D., Johnson, H., Reilmann, R., Landwehrmeyer, B., & Stout, J. C.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- University of Iowa (US)
- University of British Columbia (CA)
- Leiden University (NL)
- St Mary's Hospital (GB)
- University of Oxford (GB)
- CHDI Foundation (US)
- Harvard University (US)
- University of Münster (DE)
- Indiana University Bloomington (US)
- Corresponding author
- Tabrizi, Sarah J
- ORCID
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 8
- Issue
- 9
- Pages
- 791-801
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3725974
- OpenAlex
- W2124660038
- Cited by
- 984
- References
- 40
- Citations by year
- 2026: 37 · 2025: 44 · 2024: 51 · 2023: 44 · 2022: 56 · 2021: 64 · 2020: 69 · 2019: 63 · 2018: 74 · 2017: 59 · 2016: 54 · 2015: 70 · 2014: 63 · 2013: 63 · 2012: 69
- FWCI
- 23.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10123)
- National Institute of Neurological Disorders and Stroke (R01NS042861, P01NS058793)
- National Center for Research Resources (M01RR001066)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Huntington's disease, TRACK-HD, premanifest Huntington's disease, biomarkers, brain volume, gray and white matter, motor impairment, eye movement disorders, cognitive impairment, neuropsychiatric symptoms, 3T MRI, multicenter study
- MeSH terms
- Adolescent, Adult, Aged, Atrophy, Brain, Cognition Disorders, Cross-Sectional Studies, Female, Genetic Testing, Genetic Carrier Screening, Humans, Huntington Disease, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Predictive Value of Tests, Reference Values, Cohort Studies, Biomarkers, Disease Progression, Genetic Predisposition to Disease, Early Diagnosis, Young Adult
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