The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Apolipoprotein E and cognitive change in an elderly population
Abstract
The apolipoprotein E (apoE) ε4 allele is overrepresented, and the apoE ε2 allele underrepresented, in Alzheimer's disease. To assess the risk of cognitive impairment in individuals with these genotypes in the general population, we studied a population‐based sample of 1,899 individuals 65 years and older as a follow‐up to the Iowa 65+ Rural Health Study. Multiple regression and logistic regression analyses demonstrated significant effects of apoE ε4 and apoE ε2 in predicting performance on a delayed recall task over a 4‐ to 7‐year period. The magnitude of this effect was, however, fairly modest, with odds ratios for developing impairment of approximately 1.37 (95% confidence interval: 1.007, 1.850; p = 0.045) for apoE ε4 and 0.53 (95% confidence interval: 0.368, 0.777; p = 0.001) for apoE ε2. These effects were more pronounced in women than men. Importantly, 85% of elderly apoE ε4/4 individuals (average age, 81) scored in the unimpaired range on a screening mental status test. Thus, many individuals reach old age without cognitive impairment despite inheritance of one or two apoE ε4 alleles. This suggests that apoE genotyping will have limited utility as a diagnostic or prognostic indicator of cognitive decline in individuals.
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Cites
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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920
Neuropsychological detection and characterization of preclinical Alzheimer’s disease
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Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
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Self-citationOrdovas, J. M., Litwack-Klein, L., Wilson, P. W., Schaefer, M. M., & Schaefer, E. J. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38690-9 · Cited by 238
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Cited by
Apolipoprotein E: Far More Than a Lipid Transport Protein
Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer’s disease
Small, G. W., Ercoli, L. M., Silverman, D. H. S., Huang, S.-C., Komo, S., Bookheimer, S. Y., Lavretsky, H., Miller, K., Siddarth, P., Rasgon, N. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090106797 · Cited by 790
Haan, M. N. (1999) · JAMA · doi:10.1001/jama.282.1.40 · Cited by 457
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406
Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160826 · Cited by 360
Metadata
- Authors
- Hyman, B. T., Gomez‐Isla, T., Briggs, M., Chung, H., Nichols, S., Kohout, F., & Wallace, R.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1996-07
- Volume
- 40
- Issue
- 1
- Pages
- 55-66
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2091775763
- Cited by
- 205
- References
- 8
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hyman, B. T., Gomez‐Isla, T., Briggs, M., Chung, H., Nichols, S., Kohout, F., & Wallace, R. (1996). Apolipoprotein E and cognitive change in an elderly population. Annals of Neurology. https://doi.org/10.1002/ana.410400111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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