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Cited by 26Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

The Association Between Apolipoprotein E Allele 4 and Late-Onset Alzheimer's Disease: Pathogenic Relationship or Differential Survival Bias

Riggs, J. E., Keefover, R. W.·1994·Archives of Neurology
DOI 10.1001/archneur.1994.00540200024011
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Abstract

Recent genetic epidemiological studies 1-3 have documented a significant association between the apolipoprotein E (ApoE) allele e4 (ApoE-e4) and late-onset familial and sporadic Alzheimer's disease (AD). This association is so impressive that one group of investigators concluded that homozygosity for ApoE-e4 was virtually sufficient to cause AD by age 80. 1 However, the bane of any epidemiological association is bias. 4 We suggest that selection bias may have significantly contributed to, or even produced, the observed association between ApoE-e4 and late-onset AD. The three common ApoE alleles are e2, e3, and e4. The relative frequencies of these alleles in healthy population samples are about 8%, 76%, and 14%, respectively. 5-6 Individuals with ApoE-e4 have an increased risk of premature coronary artery disease. 7-9 As a result of earlier mortality due to heart disease, the relative frequency of the e4 allele was predicted, and found, to decline with age. 10-11 This

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Crossref · 10.1001/archneur.1994.00540200024011

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  • The studies challenge the suggestion that differential survival bias contributed to or produced the association between the e4 allele and Alzheimer's disease.

    “They challenge the suggestion 39 that a differential survival bias (i.e., the selection of a distinctive subgroup of surviving carriers of the e4 allele in casecontrol studies) contributed to, or even produced, the association between the e4 allele and Alzheimer's disease”

    From Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E (1996) · cites this paper as [39]

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Authors
Riggs, J. E., & Keefover, R. W.
ORCID
Riggs, J. E.
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
1994-08-01
Volume
51
Issue
8
Pages
750-750
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.1994.00540200024011
OpenAlex
W2091716473
Cited by
26
References
17
FWCI
5.20
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
apolipoprotein E, APOE ε4, late-onset Alzheimer's disease, selection bias, genetic association, allele frequency, coronary artery disease mortality
MeSH terms
Alleles, Alzheimer Disease, Apolipoproteins E, Humans, Selection Bias, Apolipoprotein E4

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