The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
Abstract
The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q 10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q 10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age‐ and sex‐matched control subjects and that the levels of coenzyme Q 10 and the activities of complex I and complex II/III were significantly correlated.
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“In this study, oral administration of CoQ10 in PD patients was well tolerated and resulted in significant, dose-dependent increases in plasma CoQ10 levels.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [159]
In the citing paper
“We found a significant reduction in CoQ10 levels in mitochondria isolated from platelets of PD patients, that directly correlated with a decrease in complex-I activity159.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [159]
Citations
Cites
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Self-citationLovastatin decreases coenzyme Q levels in humans.
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Research works printed but not linked: 1
- Gotz ME, 1996, Platelet coenzyme Q10 in Parkinson's disease, Mov Disord, 11, 127
Cited by
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The Role of Oxidative Stress in Parkinson's Disease
Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Metabolism and function of coenzyme Q
Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026
Fox, S. H., Katzenschlager, R., Lim, S., Barton, B. R., de Bie, R. M. A., Seppi, K., Coelho, M. M., & Sampaio, C. (2018) · Movement Disorders · doi:10.1002/mds.27372 · Cited by 1,009
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline
Shults, C. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1541 · Cited by 984
Self-citation
Metadata
- Authors
- Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F.
- Affiliations
- United States Department of Veterans Affairs (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Shults, Clifford W.
- ORCID
- Haas, Richard H.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1997-08
- Volume
- 42
- Issue
- 2
- Pages
- 261-264
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2084464741
- Cited by
- 326
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 16 · 2013: 14 · 2012: 11
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns032365-03, 5r01ns029504-03)
- U.S. Public Health Service (P01 12992)
- National Institute of Neurological Disorders and Stroke (R01 NS32365, R01 NS29504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- coenzyme Q10, Parkinson's disease, mitochondrial complex I, platelet mitochondria, mitochondrial electron transport chain, mitochondrial dysfunction
- MeSH terms
- Blood Platelets, Coenzymes, Female, Humans, Male, Mitochondria, Multienzyme Complexes, Oxidoreductases, Parkinson Disease, Reference Values, Succinate Dehydrogenase, Electron Transport Complex III, Ubiquinone, NAD(P)H Dehydrogenase (Quinone), Electron Transport Complex II
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