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Cited by 93Coenzyme Q10 studies and effectsParkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Altered redox state of platelet coenzyme Q 10 in Parkinson's disease

Götz, M. E., Gerstner, A., Harth, R., Dirr, A., Janetzky, B., Kuhn, W., Riederer, P., Gerlach, M.·2000·Journal of Neural Transmission
DOI 10.1007/s007020050003
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Abstract

Background The reduced form of coenzyme Q10 (CoQ10) acts as a lipophilic antioxidant and participates in electron and proton transport of the respiratory chain in the inner mitochondrial membrane. An alteration in CoQ10 redox state may thus reflect a change in membrane electron transport and the effectiveness of defense against toxic reactive oxygen species such as hydrogen peroxide and superoxide. In Parkinson's disease alterations in the activities of complex I have been reported in substantia nigra and platelets. Deficiency of mitochondrial enzyme activities could affect electron transport which might be reflected by the platelet CoQ10 redox state.Method We have determined concentrations of the reduced and oxidized forms of CoQ10 and the activity of monoamine oxidase B in platelets isolated from parkinsonian patients and age- and gender-matched controls.Results Platelet CoQ10 redox ratios (reduced CoQ10 to oxidized CoQ10) and the ratio of the reduced form, compared with total platelet CoQ10, were significantly decreased in de novo parkinsonian patients. Platelet CoQ10 redox ratios were further decreased by L-DOPA treatment (not significant), whilst selegiline treatment partially restored CoQ10 redox ratios. Monoamine oxidase activities in non-selegiline treated patients were similar to controls.Interpretation Our results either suggest an impairment of electron transport or a higher need for reduced forms of CoQ10 in the platelets of even de novo parkinsonian patients. However, the CoQ10 redox ratio was not correlated to disease severity, as determined by the Hoehn and Yahr PD disability classification, suggesting that this parameter may not be useful as a peripheral trait marker for the severity of PD but as an early state marker of PD.

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  • The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid of PD patients and in plasma of ALS patients.

    “The ratio of reduced to oxidized CoQ10 is significantly reduced in the platelets and cerebrospinal fluid (CSF) of PD patients156, 157 and in plasma of ALS patients158.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [156]

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Authors
Götz, M. E., Gerstner, A., Harth, R., Dirr, A., Janetzky, B., Kuhn, W., Riederer, P., & Gerlach, M.
Affiliations
  • University of Würzburg (DE)
  • St. Josef-Hospital (DE)
  • Technische Universität Dresden (DE)
ORCID
Venue
Journal of Neural Transmission
Publisher
Springer Science and Business Media LLC
Published
2000-01-20
Volume
107
Issue
1
Pages
41-48
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
DOI
10.1007/s007020050003
OpenAlex
W1993308019
Cited by
93
References
15
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 9 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
Parkinson's disease, coenzyme Q10, redox state, platelets, monoamine oxidase B, mitochondrial electron transport chain, selegiline, L-DOPA, oxidative stress, biomarkers, disease severity
MeSH terms
Aged, Aged, 80 and over, Antioxidants, Antiparkinson Agents, Blood Platelets, Coenzymes, Female, Humans, Levodopa, Male, Middle Aged, Monoamine Oxidase, Oxidation-Reduction, Parkinson Disease, Selegiline, Ubiquinone, Biomarkers

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