CoChat
Sign Up
Cited by 395Multiple Sclerosis Research StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Magnetization transfer changes in the normal appering white matter precede the appearance of enhancing lesions in patients with multiple sclerosis

Filippi, Massimo, Rocca, Maria A., Martino, Gianvito, Horsfield, Mark A., Comi, Giancarlo·1998·Annals of Neurology
DOI 10.1002/ana.410430616
Open this paper in CoChat — free account

Abstract

Serial monthly magnetization transfer (MT) imaging was performed to evaluate whether a change of the normal appearing white matter (NAWM), which precedes the appearance of enhancing lesions, is seen in patients with multiple sclerosis (MS). Every 4 weeks for 3 months, 10 patients with relapsing-remitting MS were scanned with a T1-weighted sequence, 20 minutes after injection with 0.3 mmol/kg gadolinium-DTPA (Gd-DTPA). During each of the monthly sessions, MT and dual echo scans were also performed before Gd-DTPA injection. On coregistered images, the MT ratio (MTR) was measured in NAWM subsequently involved by enhancing lesions, in NAWM areas on the same slices but outside any present or future MR abnormality, and in enhancing lesions at the time of their appearance. Forty-eight new enhancing lesions with no corresponding abnormalities on previous scans were identified. Their average MTR was 33.1% (+/-8.4%). Three, 2, and 1 month before enhancement appearance, the mean MTR in NAWM, measured from areas corresponding to future enhancing lesions, was significantly lower than the mean MTR in NAWM outside enhancing areas; the MTR decreased steadily as the time when the enhanced lesion approached. These results suggest that changes in the NAWM of patients with MS occur before lesions become evident on conventional MRI scans.

Overview

Integrity signals

Registry

Crossref · 10.1002/ana.410430616

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 3

  1. Dousset V, 1995, Magnetization transfer profile of demyelinating CNS lesions, Proc Soc Magn Reson., 1, 114
  2. Lexa FJ, 1994, MR of Wallerian degeneration in the feline visual system: characterization by magnetization transfer rate with histopathologic correlation, AJNR., 15, 201
  3. Dousset V, 1994, MR imaging including diffusion and magnetization transfer of chronic relapsing experimental encephalomyelitis: correlation with immunological and pathological data, Proc Soc Magn Reson., 1, 483

Cited by

Sorted by citations

See all 395

Related

See all

Metadata

Authors
Filippi, M., Rocca, M. A., Martino, G., Horsfield, M. A., & Comi, G.
Affiliations
  • University of Milan (IT)
  • University of Leicester (GB)
Corresponding author
Filippi, Massimo
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
1998-06
Volume
43
Issue
6
Pages
809-814
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410430616
OpenAlex
W2102993505
Cited by
395
References
31
Citations by year
2026: 3 · 2025: 2 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 16 · 2012: 10
FWCI
18.79
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2321 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
multiple sclerosis, normal-appearing white matter, magnetization transfer ratio, enhancing lesions, lesion progression, relapsing-remitting multiple sclerosis, Gd-DTPA, white matter changes
MeSH terms
Adult, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Magnetics, Male, Multiple Sclerosis, Myelin Sheath, Nerve Fibers, Protons, Disease Progression

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review