The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy
Abstract
Brain areas damaged by stroke and seizures express high levels of the 27‐kd heat shock protein (HSP72). Whether HSP72 represents merely a marker of stress or plays a role in improving neuron survival in these cases has been debated. Some induced tolerance experiments have provided correlative evidence for a neuroprotective effect, and others have documented neuroprotection in the absence of HSP72 synthesis. We report that gene transfer therapy with defective herpes simplex virus vectors overexpressing hsp 72 improves neuron survival against focal cerebral ischemia and systemic kainic acid administration. HSP72 overexpression improved striatal neuron survival from 62.3 to 95.4% in rats subjected to 1 hour of middle cerebral artery occlusion, and improved survival of hippocampal dentate gyrus neurons after systemic kainic acid administration, from 21.9 to 64.4%. We conclude that HSP72 may participate in processes that enhance neuron survival during transient focal cerebral ischemia and excitotoxin‐induced seizures.
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‘Ischemic tolerance’ phenomenon found in the brain
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Kainic acid seizures in the rat
Sperk, G. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90019-1 · Cited by 688
Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons
Kirino, T., Tsujita, Y., & Tamura, A. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.62 · Cited by 582
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Localization of 70-kDa stress protein induction in gerbil brain after ischemia
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Cited by
Molecular targets in cerebral ischemia for developing novel therapeutics
Mehta, S. L., Manhas, N., & Raghubir, R. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.11.003 · Cited by 708
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
Sapolsky, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00971-9 · Cited by 699
Self-citationHeat shock proteins: Cellular and molecular mechanisms in the central nervous system
Stetler, R. A., Gan, Y., Zhang, W., Liou, A. K., Gao, Y., Cao, G., & Chen, J. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.05.002 · Cited by 305
Lucassen, P. J., Müller, M. B., Holsboer, F., Bauer, J., Holtrop, A., Wouda, J., Hoogendijk, W. J. G., De Kloet, E. R., & Swaab, D. F. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63988-0 · Cited by 286
Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263
Metadata
- Authors
- Yenari, M. A., Fink, S. L., Sun, G. H., Chang, L. K., Patel, M. K., Kunis, D. M., Onley, D., Ho, D. Y., Sapolsky, R. M., & Steinbrg, G. K.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1998-10
- Volume
- 44
- Issue
- 4
- Pages
- 584-591
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2062362233
- Cited by
- 313
- References
- 43
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. https://app.cochat.ai/papers/10.1002/ana.410440403
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- Yenari, M. A., Fink, S. L., Sun, G. H., Chang, L. K., Patel, M. K., Kunis, D. M., Onley, D., Ho, D. Y., Sapolsky, R. M., & Steinbrg, G. K. (1998). Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Annals of Neurology. https://doi.org/10.1002/ana.410440403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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