Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060 · see citing works

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950 · see citing works

Protein Oxidation and Aging

Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701 · see citing works

The mitochondrial permeability transition

Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Evolution of ageing

Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007 · see citing works

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

Sherman, F. (1982) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(82)90271-7 · Cited by 1,361 · see citing works

Oxidative stress and apoptosis

Kannan, K., & Jain, S. K. (2000) · Pathophysiology · doi:10.1016/s0928-4680(00)00053-5 · Cited by 1,291 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

Sian, J., Dexter, D. T., Lees, A. J., Daniel, S., Agid, Y., Javoy‐Agid, F., Jenner, P., & Marsden, C. D. (1994) · Annals of Neurology · doi:10.1002/ana.410360305 · Cited by 1,161 · see citing works

Oxidative stress and Alzheimer disease

Christen, Y. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.621s · Cited by 1,158 · see citing works

MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

Shadel, G. S., & Clayton, D. A. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.409 · Cited by 1,059 · see citing works

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

DEXTER, D. T., CARAYON, A., JAVOY-AGID, F., AGID, Y., WELLS, F. R., DANIEL, S. E., LEES, A. J., JENNER, P., & MARSDEN, C. D. (1991) · Brain · doi:10.1093/brain/114.4.1953 · Cited by 1,043 · see citing works

Oxidative stress and the molecular biology of antioxidant defenses.

Scandalios, J. G. (1997) · Cited by 1,037 · see citing works

Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works

Protein Oxidation

Stadtman, E. R., & Levine, R. L. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06187.x · Cited by 1,037 · see citing works

Antioxidant defence mechanisms: From the beginning to the end (of the beginning)

Halliwell, B. B. (1999) · Free Radical Research · doi:10.1080/10715769900300841 · Cited by 1,023 · see citing works

Cellular Defenses against Unfolded Proteins

Sherman, M. Y., & Goldberg, A. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00177-5 · Cited by 984 · see citing works

A CASE OF SEVERE HYPERMETABOLISM OF NONTHYROID ORIGIN WITH A DEFECT IN THE MAINTENANCE OF MITOCHONDRIAL RESPIRATORY CONTROL: A CORRELATED CLINICAL, BIOCHEMICAL, AND MORPHOLOGICAL STUDY

Luft, R., Ikkos, D., Palmieri, G. M. A., Ernster, L., & Afzelius, B. A. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104637 · Cited by 981 · see citing works

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897 · see citing works

Evolution of ageing

Kirkwood, T. B. L. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00419-5 · Cited by 801 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · see citing works

Parkinson's disease: A disorder due to nigral glutathione deficiency?

Perry, T. L., Godin, D. V., & Hansen, S. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90390-1 · Cited by 753 · see citing works

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosisPreprint

Zong, W.-X., Edelstein, L., Chen, C.-L., Bash, J., & Gélinas, C. (1999) · Genes & Development · doi:10.1101/gad.13.4.382 · Cited by 738 · see citing works

Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

Varadarajan, S., Yatin, S., Aksenova, M., & Butterfield, D. A. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4274 · Cited by 735 · see citing works

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721 · see citing works

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703 · see citing works

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

Hunot, S., Brugg, B., Ricard, D., Michel, P. P., Muriel, M., Ruberg, M., Faucheux, B. A., Agid, Y., & Hirsch, É. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7531 · Cited by 678 · see citing works

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart

Di Lisa, F., Menabò, R., Canton, M., Barile, M., & Bernardi, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006825200 · Cited by 678 · see citing works

The Molecular biology of the yeast saccharomyces, life cycle and inheritance

Strathern, J. N., Jones, E. W., & Broach, J. R. (1981) · Cold Spring Harbor Laboratory eBooks · Cited by 651 · see citing works

On the nature of the aging process

Szilard, L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.30 · Cited by 651 · see citing works

Role of mitochondria in oxidative stress and ageing

Lenaz, G. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00120-0 · Cited by 650 · see citing works

Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

Morimoto, R. I., & SANTORO, M. G. (1998) · Nature Biotechnology · doi:10.1038/nbt0998-833 · Cited by 634 · see citing works

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2642 · Cited by 611 · see citing works

Heat shock factors and the control of the stress response

SANTORO, M. G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00299-3 · Cited by 581 · see citing works

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

Sayre, L. M., Perry, G. L., Harris, P. L. R., Liu, Y. A., Schubert, K. A., & Smith, M. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740270.x · Cited by 538 · see citing works

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Chomyn, A., Martinuzzi, A., Yoneda, M., Daga, A., Hurko, O., Johns, D. R., Lai, S. T., Nonaka, I., Angelini, C. I., & Attardi, G. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4221 · Cited by 491 · see citing works

Role of Mitochondria in Oxidative Stress and Aging

Lenaz, G., Bovina, C., D’Aurelio, M., Fato, R., Formiggini, G., Genova, M. L., GIULIANO, G., Pich, M. M., Paolucci, U., Castelli, G. P., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02094.x · Cited by 489 · see citing works

The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death

Petronilli, V., Penzo, D., Scorrano, L., Bernardi, P., & Di Lisa, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010604200 · Cited by 472 · see citing works

Reactive oxygen species, mitochondria, apoptosis and aging

Papa, S., & Skulachev, V. P. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6111-8_47 · Cited by 462 · see citing works

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

Mattson, M. P., Culmsee, C., Yu, Z., & Camandola, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740443.x · Cited by 449 · see citing works

Aging and oxidative stress: Modulation by dietary restriction

Yu, B. P. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00162-1 · Cited by 443 · see citing works

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

Hagen, T. M., Yowe, D. L., Bartholomew, J. C., Wehr, C. M., Katherine, L. B. B., Park, J.-Y., & Ames, B. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3064 · Cited by 434 · see citing works

Therapeutic modulation of brain temperature: relevance to ischemic brain injury.

Ginsberg, M. D., Sternau, L., Globus, M. Y. ‐., et al. (1992) · PubMed · Cited by 428 · see citing works

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

Lovell, M. A., Ehmann, W. D., Mattson, M. P., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00108-5 · Cited by 413 · see citing works

Multiple NF-κB Enhancer Elements Regulate Cytokine Induction of the Human Inducible Nitric Oxide Synthase Gene

Taylor, B. S., de Vera, M. E., Ganster, R. W., Wang, Q., Shapiro, R. A., Morris, S. M., Billiar, T. R., & Geller, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15148 · Cited by 413 · see citing works

Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: An HPLC and ESR study

Dexter, D. T., Holley, A. E., Flitter, W. D., Slater, T. F., Wells, F. R., Daniel, S. E., Lees, A. J., Jenner, P. G., & MARSDEN, C. D. (1994) · Movement Disorders · doi:10.1002/mds.870090115 · Cited by 407 · see citing works

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 398 · see citing works

Chapter 7 Protein Oxidation Processes in Aging Brain

Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390 · see citing works

Reactive oxygen species, mitochondria, apoptosis and aging

Papa, S., & Скулачев, В. П. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006873518427 · Cited by 389 · see citing works

An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration

Cassarino, D. S., & Bennett, J. P. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00046-0 · Cited by 379 · see citing works

Energy Thresholds in Brain Mitochondria

Davey, G. P., Peuchen, S., & Clark, J. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12753 · Cited by 361 · see citing works

Longevity, Genes, and Aging

Jazwinski, S. M. (1996) · Science · doi:10.1126/science.273.5271.54 · Cited by 354 · see citing works

Evolutionary Theories of Aging: Confirmation of a Fundamental Prediction, with Implications for the Genetic Basis and Evolution of Life Span

Ricklefs, R. E. (1998) · The American Naturalist · doi:10.1086/286147 · Cited by 350 · see citing works

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

Beutner, G., Rück, A., Riede, B., Welte, W., & Brdiczka, D. G. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01092-7 · Cited by 337 · see citing works

INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS

Nass, S., & Nass, M. M. K. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.3.613 · Cited by 332 · see citing works

Discussion

(1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00056-1 · Cited by 330 · see citing works

Mitochondrial Implication in Accidental and Programmed Cell Death: Apoptosis and Necrosis

Zamzami, N., Hirsch, T., Dallaporta, B., PETIT, P. X., & Kroemer, G. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022694131572 · Cited by 326 · see citing works

Caspase Pathways, Neuronal Apoptosis, and CNS Injury

Eldadah, B. A., & Faden, A. I. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.811 · Cited by 319 · see citing works

Chaperones Hsp70 and Hsp40 Suppress Aggregate Formation and Apoptosis in Cultured Neuronal Cells Expressing Truncated Androgen Receptor Protein with Expanded Polyglutamine Tract

Kobayashi, Y., Kume, A., Li, M., Doyu, M., Hata, M., Ohtsuka, K., & Sobue, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8772 · Cited by 316 · see citing works

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

Yenari, M. A., Fink, S. L., Sun, G. H., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410440403 · Cited by 315 · see citing works

Mitochondrial involvement in Parkinson’s disease, Huntington’s disease, hereditary spastic paraplegia and Friedreich’s ataxia

Schapira, A. H. V. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00164-9 · Cited by 310 · see citing works

Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression

Pettegrew, J. W., Levine, J., & McClure, R. J. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000805 · Cited by 304 · see citing works

The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism

Cassarino, D. S., Parks, J. K., Parker, W. D., & Bennett, J. P. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00083-0 · Cited by 304 · see citing works

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

Münch, G. W., Schinzel, R., Loske, C., Wong, A. O., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G. L., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050069 · Cited by 302 · see citing works

Threshold Effect and Tissue Specificity

Rossignol, R., Malgat, M., Mazat, J.-P., & Letellier, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33426 · Cited by 288 · see citing works

NO Synthase and NO-Dependent Signal Pathways in Brain Aging and Neurodegenerative Disorders: The Role of Oxidant/Antioxidant Balance

Calabrese, V., Bates, T. E., & Stella, A. M. G. (2000) · Neurochemical Research · doi:10.1023/a:1007604414773 · Cited by 285 · see citing works

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

Müller‐Höcker, J. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90006-9 · Cited by 284 · see citing works

Intense oxidative DNA damage promoted by l ‐DOPA and its metabolites implications for neurodegenerative disease

Spencer, J. P. E., Jenner, A. M., Aruoma, O. I., Evans, P., Kaur, H., Dexter, D. T., Jenner, P. G., Lees, A. J., Marsden, D. C., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01056-0 · Cited by 278 · see citing works

Mitochondrial Genetics and FunctionsPreprint

Dujon, B. (1981) · Cold Spring Harbor Monograph Archive · doi:10.1101/87969139.11a.505 · Cited by 275 · see citing works

Cybrids in Alzheimer's disease: a cellular model of the disease?

Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Maguire, D. J., Maguire, R. S., Bennett, J. P., Davis, R. E., & Parker, W. D. (1997) · Neurology · doi:10.1212/wnl.49.4.918 · Cited by 272 · see citing works

Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications

Papa, S. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00077-1 · Cited by 264 · see citing works

Endothelial Heme Oxygenase-1 Induction by Hypoxia

Motterlini, R., Foresti, R., Bassi, R., Calabrese, V., Clark, J., & Green, C. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13613 · Cited by 261 · see citing works

Cybrids in Alzheimer's disease: A cellular model of the disease?

Swerdlow, R. H., & Parker, D. W. (1998) · Neurology · doi:10.1212/wnl.51.1.326-a · Cited by 260 · see citing works

Acetyl- l -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M. H., & Ames, B. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9562 · Cited by 252 · see citing works

Mitochondrial dysfunction in Parkinson's disease

Greenamyre, J. T., MacKenzie, G. M., Peng, T., & Stephans, S. E. (1999) · Biochemical Society Symposia · doi:10.1042/bss0660085 · Cited by 248 · see citing works

Mitotic signaling by β‐amyloid causes neuronal death

Copani, A., Condorelli, F., CARUSO, A., Vancheri, C., Sala, A., Stella, A. M. G., Canonico, P. L., Nicoletti, F., & Sortino, M. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2225 · Cited by 246 · see citing works

Neuroprotective signaling and the aging brain: take away my food and let me run11Published on the World Wide Web on 24 August 2000.

Mattson, M. P. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02790-6 · Cited by 239 · see citing works

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Bartzokis, G., Sultzer, D. L., Cummings, J. L., Holt, L. E., Hance, D. B., Henderson, V. W., & Mintz, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.47 · Cited by 235 · see citing works

Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

Kristal, B. S., & Dubinsky, J. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020524.x · Cited by 229 · see citing works

The neuroprotective potential of heat shock protein 70 (HSP70)

Yenari, M. A., Giffard, R. G., Sapolsky, R. M., & Steinberg, G. K. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01599-3 · Cited by 229 · see citing works

Cell death mechanisms in Parkinson's disease

Jellinger, K. A. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050001 · Cited by 227 · see citing works

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini, L., Romano, G., & Senin, U. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815160 · Cited by 215 · see citing works

Mitochondrial Aging: Open Questionsa

Beckman, K. B., & Ames, B. N. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09897.x · Cited by 211 · see citing works

Huntington's disease progression

Andrews, T., Weeks, R. A., Turjanski, N., Gunn, R. N., Watkins, L., Sahakian, B. J., Hodges, J. R., Rosser, A., Wood, N. W., & Brooks, D. J. (1999) · Brain · doi:10.1093/brain/122.12.2353 · Cited by 205 · see citing works

Plasma Concentrations of Vitamins A and E and Carotenoids in Alzheimer's Disease

Zaman, Z., ROCHE, S., FIELDEN, P., Frost, P., Niriella, D. C., & CAYLEY, A. C. D. (1992) · Age and Ageing · doi:10.1093/ageing/21.2.91 · Cited by 202 · see citing works

Tissue variation in the control of oxidative phosphorylation: Implication for mitochondrial diseases

ROSSIGNOL, R., LETELLIER, T., MALGAT, M., ROCHER, C., & MAZAT, J.-P. (2000) · Biochemical Journal · doi:10.1042/bj3470045 · Cited by 202 · see citing works

Neurotoxic Aβ peptides increase oxidative stress in vivo through NMDA‐receptor and nitric‐oxide‐synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro

Parks, J. K., Smith, T. S., Trimmer, P. A., Bennett, J. P., & Parker, W. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00112.x · Cited by 198 · see citing works

Sequential Serum-dependent Activation of CREB and NRF-1 Leads to Enhanced Mitochondrial Respiration through the Induction of Cytochrome c

Herzig, R. P., Scacco, S., & Scarpulla, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13134 · Cited by 197 · see citing works

β‐Amyloid fragment 25–35 selectively decreases complex IV activity in isolated mitochondria

Canevari, L., Clark, J. B., & Bates, T. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01028-5 · Cited by 196 · see citing works

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

Ozawa, T., Tanaka, M., Ikebe, S.-I., Ohno, K., Kondo, T., & Mizuno, Y. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90698-m · Cited by 187 · see citing works

Cellular Physiology of STAT3: Where’s the Cytoplasmic Monomer?*

Ndubuisi, M., Guo, G., Fried, V., Etlinger, J. D., & Sehgal, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25499 · Cited by 185 · see citing works

Overexpression of Heme Oxygenase in Neuronal Cells, the Possible Interaction with Tau

Takeda, A., Perry, G. L., Abraham, N. G., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5395 · Cited by 183 · see citing works

Mitochondrial Free Radical Signal in Ceramide‐Dependent Apoptosis: A Putative Mechanism for Neuronal Death in Parkinson's Disease

France‐Lanord, V., Brugg, B., Michel, P. P., Agid, Y., & Ruberg, M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041612.x · Cited by 182 · see citing works

Neuronal death and survival in two models of hypoxic-ischemic brain damage

Walton, M. R., Connor, B. J., Lawlor, P. A., Young, D., Sirimanne, E. S., Gluckman, P. D., Cole, G. M., & Dragunow, M. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00053-8 · Cited by 164 · see citing works

Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

Qin, Z., Wang, Y., Nakai, M., & Chase, T. N. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.33 · Cited by 163 · see citing works

Functional expression of p-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes

Declèves, X., Régina, A., Laplanche, J., Roux, F. S., Boval, B., Launay, J., & Scherrmann, J. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000601)60:5 · Cited by 159 · see citing works

Amyloidogenicity of rodent and human βA4 sequences

Dyrks, T., Dyrks, E., Masters, C. L., & Beyreuther, K. T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81399-k · Cited by 158 · see citing works

c-Jun, JNK/SAPK Kinase and Transcription Factor NF-κB Are Selectively Activated in Astrocytes, but not Motor Neurons, in Amyotrophic Lateral Sclerosis

Migheli, A., Piva, R., ATZORI, C., et al. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199712000-00006 · Cited by 158 · see citing works

Microglia, Scavenger Receptors, and the Pathogenesis of Alzheimer’s Disease

Khoury, J. B. E., Hickman, S., Thomas, C. A., Loike, J. D., & Silverstein, S. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00036-0 · Cited by 157 · see citing works

A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB

Mirza, A., Liu, S. L., Frizell, E., et al. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.2.g281 · Cited by 157 · see citing works

Free radical theory of aging: dietary implications

Harman, D. (1972) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/25.8.839 · Cited by 154 · see citing works

Roles of molecular chaperones in the nervous system

Ohtsuka, K., & Suzuki, T. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00325-7 · Cited by 153 · see citing works

The yeast mitochondrial RNA polymerase specificity factor, MTF1, is similar to bacterial sigma factors.

Jang, S., & Jaehning, J. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54622-6 · Cited by 151 · see citing works

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

Pettegrew, J. W., Klunk, W. E., Panchalingam, K., Kanfer, J. N., & McClure, R. J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)80001-8 · Cited by 148 · see citing works

OxyR: A Regulator of Antioxidant Genes

Storz, G., & Tartaglia, L. A. (1992) · Journal of Nutrition · doi:10.1093/jn/122.suppl_3.627 · Cited by 142 · see citing works

Trial of d-alpha-tocopherol in Huntington's disease

Peyser, C. E., Folstein, M. F., Chase, G. A., STARKSTEIN, S. E., Brandt, J., Cockrell, J. R., Bylsma, F., Coyle, J. T., McHugh, P. R., & Folstein, S. E. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.12.1771 · Cited by 139 · see citing works

Astrocyte‐Derived Nitric Oxide Causes Both Reversible and Irreversible Damage to the Neuronal Mitochondrial Respiratory Chain

Stewart, V. C., Sharpe, M. A., Clark, J. B., & Heales, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750694.x · Cited by 133 · see citing works

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age

Cottrell, D. A., Blakely, E. L., Johnson, M. A., Ince, P. G., Borthwick, G. M., & Turnbull, D. M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00234-7 · Cited by 132 · see citing works

Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions

Smith, T. S., & Bennett, J. P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00429-0 · Cited by 129 · see citing works

The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria

Lutz, T., Westermann, B., Neupert, W., & Herrmann, J. M. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4527 · Cited by 125 · see citing works

Protein Oxidation in Aging Braina

Smith, C. D., Carney, J. M., TATSUMO, T., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38654.x · Cited by 124 · see citing works

cAMP-dependent Phosphorylation of the Nuclear Encoded 18-kDa (IP) Subunit of Respiratory Complex I and Activation of the Complex in Serum-starved Mouse Fibroblast Cultures

Scacco, S., Vergari, R., Scarpulla, R. C., Technikova-Dobrova, Z., Sardanelli, A. M., Lambo, R., Lorusso, V., & Papa, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001174200 · Cited by 121 · see citing works

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

Li, S.-H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2859 · Cited by 119 · see citing works

Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage

Forster, M. J., Sohal, B. H., & Sohal, R. S. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.11.b522 · Cited by 118 · see citing works

The effect of aging and acetyl-l-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria

Paradies, G., Ruggiero, F. M., Gadaleta, M. N., & Quagliariello, E. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90103-s · Cited by 112 · see citing works

Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria

Paradies, G., & Ruggiero, F. M. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90060-h · Cited by 111 · see citing works

Irreversible Inhibition of Mitochondrial Complex I by 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1): A Putative Nigral Endotoxin of Relevance to Parkinson's Disease

Li, H., & Dryhurst, G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041530.x · Cited by 110 · see citing works

Caloric restriction improves thermotolerance and reduces hyperthermia‐induced cellular damage in old rats

HALL, D. M., Oberley, T. D., Moseley, P. L., Buettner, G. R., Oberley, L. W., Weindruch, R. H., & Kregel, K. C. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.1.78 · Cited by 107 · see citing works

A 1-year controlled trial of acetyl- l -carnitine in early-onset AD

Thal, L. J., Calvani, M., Amato, A., & Carta, A. (2000) · Neurology · doi:10.1212/wnl.55.6.805 · Cited by 102 · see citing works

Effect of aging and acetyl‐ l ‐carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria

Paradies, G., Ruggiero, F. M., Petrosillo, G., Gadaleta, M. N., & Quagliariello, E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00763-2 · Cited by 101 · see citing works

Cybrids in Alzheimer's disease: A cellular model of the disease?

Schon, E. A., Shoubridge, E. A., & Moraes, C. T. (1998) · Neurology · doi:10.1212/wnl.51.1.326 · Cited by 101 · see citing works

Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD

Bruce‐Keller, A. J., Geddes, J. W., Knapp, P. E., McFall, R. W., Keller, J. N., Holtsberg, F. W., Parthasarathy, S., Steiner, S. M., & Mattson, M. P. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00190-8 · Cited by 100 · see citing works

Stress proteins and SH-groups in oxidant-induced cell damage after acute ethanol administration in rat

Calabrese, V., Renis, M., Calderone, A., et al. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02095-0 · Cited by 100 · see citing works

Vitamin Ε as an Antioxidant/Free Radical Scavenger Against Amyloid β-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease

Butterfield, D. A., Koppal, T., Subramaniam, R., & Yatin, S. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.141 · Cited by 97 · see citing works

Oxidative stress indicators are elevated in de novo Parkinson's disease patients.

Ilic, T. V., Jovanovic, M., Jovicic, A., et al. (1999) · PubMed · Cited by 95 · see citing works

Stress Proteins and SH-Groups in Oxidant-Induced Cellular Injury After Chronic Ethanol Administration in Rat

Calabrese, V., Renis, M., Calderone, A., Russo, A., Reale, S., Barcellona, M. L., & Rizza, V. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00441-3 · Cited by 95 · see citing works

Network theory of aging

Kirkwood, T. B. L., & Kowald, A. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00171-4 · Cited by 94 · see citing works

Mutation in the NDUFS4 gene of complex I abolishes cAMP‐dependent activation of the complex in a child with fatal neurological syndrome

Papa, S., Scacco, S., Sardanelli, A. M., Vergari, R., Papa, F., Budde, S., van den Heuvel, L., & Smeitink, J. A. M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02334-6 · Cited by 94 · see citing works

HSP70 Induction in the Brain Following Ethanol Administration in the Rat: Regulation by Glutathione Redox State

Calabrese, V., Testa, G., Ravagna, A., Bates, T. E., & Stella, A. M. G. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2311 · Cited by 93 · see citing works

The evolutionary genetics of ageing and longevity

Zwaan, B. J. (1999) · Heredity · doi:10.1046/j.1365-2540.1999.00544.x · Cited by 89 · see citing works

Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl‐l‐Carnitine and N‐tert‐Butyl‐α‐phenyl‐nitronea

Hagen, T. M., Wehr, C. M., & Ames, B. N. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09904.x · Cited by 88 · see citing works

What do mitochondrial diseases teach us about normal mitochondrial functions... that we already knew: threshold expression of mitochondrial defects

Mazat, J., Rossignol, R., Malgat, M., Rocher, C., Faustin, B., & Letellier, T. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00236-x · Cited by 85 · see citing works

The effect of aging and acetyl‐L‐carnitine on the pyruvate transport andoxidation in rat heart mitochondria

Paradies, G., Petrosillo, G., Gadaleta, M. N., & Ruggiero, F. M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00809-1 · Cited by 84 · see citing works

Nitric oxide and nitric oxide synthase in Huntington's disease

Deckel, A. W. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1057 · Cited by 83 · see citing works

Increased cortical nuclear factor-κB (NF-κB) DNA binding activity after traumatic brain injury in rats

Yang, K., Mu, X. S., & Hayes, R. L. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11919-n · Cited by 82 · see citing works

Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition

Koppal, T., Subramaniam, R., Drake, J., Prasad, M. R., Dhillon, H. S., & Butterfield, D. A. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01466-2 · Cited by 77 · see citing works

Cytochrome Oxidase Inhibition: A Novel Animal Model of Alzheimer's Disease

Bennett, M. C., Diamond, D. M., Stryker, S. L., Parks, J. K., & Parker, W. D. (1992) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/002383099200500206 · Cited by 77 · see citing works

Modulating cellular aging in vitro: Hormetic effects of repeated mild heat stress on protein oxidation and glycation

Verbeke, P., Clark, B. F. C., & Rattan, S. I. S. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00143-1 · Cited by 76 · see citing works

Inhibitors of Mitochondrial Respiration, Iron (II), and Hydroxyl Radical Evoke Release and Extracellular Hydrolysis of Glutathione in Rat Striatum and Substantia Nigra

Han, J., Cheng, F., Yang, Z., & Dryhurst, G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731683.x · Cited by 74 · see citing works

The Effects of Dietary Restriction on Mitochondrial Dysfunction in Aginga

Feuers, R. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09902.x · Cited by 70 · see citing works

Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.

Calvani, M., & Arrigoni‐Martelli, E. (1999) · PubMed · Cited by 69 · see citing works

Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients.

Scarpini, E. A., Sacilotto, G., Baron, P., et al. (1997) · PubMed · Cited by 68 · see citing works

Intranuclear targeted delivery of functional NF‐κB by 70 kDa heat shock protein

Fujihara, S. M., & Nadler, S. G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.411 · Cited by 67 · see citing works

The Nature of Gerontogenes and Vitagenes: Antiaging Effects of Repeated Heat Shock on Human Fibroblasts

Rattan, S. I. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09891.x · Cited by 67 · see citing works

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

Partridge, R. S., Monroe, S., Parks, J. K., Johnson, K. L., Parker, W. D., Eaton, G. R., & Eaton, S. S. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1159 · Cited by 66 · see citing works

Alzheimer's peptide kills cells of retina in vivo

Jen, L. S., Hart, A. J., Jen, A., Relvas, J. B., Gentleman, S. M., Garey, L. J., & Patel, A. J. (1998) · Nature · doi:10.1038/32327 · Cited by 63 · see citing works

Mitochondria and ageing

Cottrell, D. A., & Turnbull, D. M. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200011000-00009 · Cited by 63 · see citing works

Acetyl L-Carnitine Slows Decline in Younger Patients With Alzheimer's Disease: A Reanalysis of a Double-Blind, Placebo-Controlled Study Using the Trilinear Approach

Brooks, J. O., Yesavage, J. A., Carta, A., & Bravi, D. (1998) · International Psychogeriatrics · doi:10.1017/s1041610298005304 · Cited by 61 · see citing works

Werner's syndrome: from clinics to genetics.

Goto, M. (2001) · PubMed · Cited by 60 · see citing works

The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes

Boerrigter, M. E. T. I., Franceschi, C., Arrigoni-Martelli, E., et al. (1993) · Carcinogenesis · doi:10.1093/carcin/14.10.2131 · Cited by 59 · see citing works

Analysis of compound heterozygous mice reveals that the Trembler mutation can behave as a gain‐of‐function allele

Adlkofer, K., Naef, R., & Suter, U. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 59 · see citing works

Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine

Paradies, G., Ruggiero, F. M., Petrosillo, G., et al. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01636-8 · Cited by 50 · see citing works

CSF and serum metabolic profile of patients with Huntington's chorea: A study by high resolution proton NMR spectroscopy and HPLC

Nicoli, F., Vion‐Dury, J., Maloteaux, J. M., Delwaide, C., Sylviane Confort-gouny, A., SCIAKY, M., & Cozzone, P. J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90168-k · Cited by 48 · see citing works

Kainic acid-induced activation of nuclear factor-κB in rat hippocampus

Matsuoka, Y., Kitamura, Y., Okazaki, M., Terai, K., & Taniguchi, T. (1999) · Experimental Brain Research · doi:10.1007/s002210050616 · Cited by 48 · see citing works

Pathophysiology of mitochondrial cell death control

Vieira, H. L. A., & Kroemer, G. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050486 · Cited by 47 · see citing works

Mitochondria and Free Radicals in Neurodegenerative Diseases

Oberley, L. W. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199805000-00010 · Cited by 43 · see citing works

Xenon-133 inhalation method for regional cerebral blood flow measurements: normal values and test-retest results.

McHenry, L. C., Merory, J. R., Bass, E. B., et al. (1978) · Stroke · doi:10.1161/01.str.9.4.396 · Cited by 41 · see citing works

Effects of acetyl-l-carnitine treatment and stress exposure on the nerve growth factor receptor (p75NGFR) mRNA level in the central nervous system of aged rats

Foreman, P. J., Perez-Polo, J. R., Angelucci, L., Ramacci, M. T., & Taglialatela, G. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00109-u · Cited by 40 · see citing works

Spatial memory and NGF levels in aged rats: Natural variability and effects of acetyl-l-carnitine treatment

Taglialatela, G., Caprioli, A., Giuliani, A., et al. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(96)00052-6 · Cited by 37 · see citing works

Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain

Suzuki, T., Mitake, S., & Murata, S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01762-x · Cited by 35 · see citing works

Dietary Restriction Augments Protection Against Induction of the Mitochondrial Permeability Transition

Kristal, B. S., & Yu, B. P. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00444-9 · Cited by 35 · see citing works

Reduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemic pretreatment

Baek, S.-H., Kim, J. Y., Choi, J.-H., et al. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02376-8 · Cited by 35 · see citing works

Action of L-Acetylcarnitine on Different Cerebral Mitochondrial Populations from Cerebral Cortex

Gorini, A., D’Angelo, A., & Villa, R. F. (1998) · Neurochemical Research · doi:10.1023/a:1020907400905 · Cited by 34 · see citing works

Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood–brain barrier

Hurst, R. D., Azam, S., Hurst, A., & Clark, J. B. (2001) · Brain Research · doi:10.1016/s0006-8993(01)01992-8 · Cited by 34 · see citing works

Attenuated c-fos mRNA Induction after Middle Cerebral Artery Occlusion in CREB Knockout Mice Does Not Modulate Focal Ischemic Injury

Hata, R., Gass, P., Mies, G., Wießner, C., & Hossmann, K.-A. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199812000-00007 · Cited by 34 · see citing works

Macromolecular Turnover in Brain during Aging

Stella, A. M. G., & Lajtha, Á. (2009) · Gerontology · doi:10.1159/000212867 · Cited by 32 · see citing works

Oxidative Stress in MitochondriaPreprint

Richter, C., & Schweizer, M. (1997) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969502.34.169 · Cited by 32 · see citing works

Formation of Propionate After Short-Term Ethanol Treatment and Its Interaction with the Carnitine Pool in Rat

Calabrese, V., & Rizza, V. (1999) · Alcohol · doi:10.1016/s0741-8329(99)00036-1 · Cited by 29 · see citing works

Effects of L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Calabrese, V., & Rizza, V. (1999) · Neurochemical Research · doi:10.1023/a:1020984114824 · Cited by 28 · see citing works

Energy Metabolism of Synaptosomal Subpopulations from Different Neuronal Systems of Rat Hippocampus: Effect of L-Acetylcarnitine Administration In Vivo

Gorini, A., D’Angelo, A., & Villa, R. F. (1999) · Neurochemical Research · doi:10.1023/a:1021008306414 · Cited by 27 · see citing works

Metabolic control analysis and mitochondrial pathologies

Letellier, T., Malgat, M., Rossignol, R., & Mazat, J. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_28 · Cited by 26 · see citing works

Effect of nitric oxide synthase induction on the expression of mitochondrial respiratory chain enzyme subunits in mixed cortical and astroglial cell cultures

Nicoletti, V. G., Caruso, A., Tendl, E. A., et al. (1998) · Biochimie · doi:10.1016/s0300-9084(00)88882-3 · Cited by 26 · see citing works

Hormesis: Implications for Public Policy Regarding Toxicants

Lave, L. B. (2001) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.22.1.63 · Cited by 25 · see citing works

Metabolic control, analysis and mitochondrial pathologies

Letellier, T., Malgat, M., Rossignol, R., et al. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006826927220 · Cited by 24 · see citing works

Expression of autoimmune disease-related antigens by cells of the immune system

Mor, F., Boccaccio, G. L., & Unger, T. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981015)54:2 · Cited by 19 · see citing works

Caloric restriction, metabolic efflciency and hormesis

Parsons, P. A. (2000) · Human & Experimental Toxicology · doi:10.1191/096032700678816052 · Cited by 18 · see citing works

VALUE OF CONTROL THEORY IN THE STUDY OF CELLULAR METABOLISM — BIOMEDICAL IMPLICATIONS

Malgat, M., Letellier, T., Jouaville, S. L., et al. (1995) · Journal of Biological Systems · doi:10.1142/s0218339095000162 · Cited by 17 · see citing works

Effects of Acetyl-L-Carnitine on the Formation of Fatty Acid Ethyl Esters in Brain and Peripheral Organs after Short-Term Ethanol Administration in Rat

Calabrese, V., Scapagnini, G., Catalano, C., et al. (2001) · Neurochemical Research · doi:10.1023/a:1011003030287 · Cited by 16 · see citing works

Lou Gehrig and Amyotrophic Lateral Sclerosis

Reider, C. R. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550170013008 · Cited by 15 · see citing works

Effects of levo-acetylcarnitine on second motoneuron survival after axotomy

Fernández, E., Palling, R., Tamburrini, G., et al. (1995) · Neurological Research · doi:10.1080/01616412.1995.11740345 · Cited by 15 · see citing works

Regulation of Cytochrome c Oxidase and FoF1-ATPase Subunits Expression in Rat Brain During Aging

Nicoletti, V., Tendi, E., Console, A., et al. (2004) · Neurochemical Research · doi:10.1023/a:1022449403619 · Cited by 14 · see citing works

Alzheimer disease: protein-protein interaction and oxidative stress.

Smith, M. A., & Perry, G. L. (1997) · PubMed · Cited by 14 · see citing works

Pharmacological Induction of Heat Shock Protein 68 Synthesis in Cultured Rat Astrocytes

Nishimura, R. N., & Dwyer, B. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.29967 · Cited by 12 · see citing works

Human longevity determinant genes.

Rothschild, H., & Jazwinski, S. M. (1998) · PubMed · Cited by 11 · see citing works

Apoptosis and the laws of thermodynamics

Nicholls, D. G., Bernardi, P., Brand, M. D., et al. (2000) · Nature Cell Biology · doi:10.1038/35036416 · Cited by 10 · see citing works

Regulation of the Ketogenic Enzyme Mitochondrial 3-Hydroxy-3-Methylglutaryl-COA Synthase in Astrocytes and Meningeal Fibroblasts

Cullingford, T. E., Bhakoo, K. K., Peuchen, S., et al. (2002) · Advances in experimental medicine and biology · doi:10.1007/0-306-46818-2_29 · Cited by 8 · see citing works

Cytotoxicity of β-amyloid peptide 25–35 on vascular smooth muscle cells and attenuation by vitamin E

Gwebu, E. T., Williams, J. W., Mathis, D., et al. (1997) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-997-0122-2 · Cited by 7 · see citing works

Discussion

(1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00059-7 · Cited by 7 · see citing works

Macromolecular Changes in the Aging Brain

Stella, A. G. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-8047-4_29 · Cited by 6 · see citing works

Benefits from caloric restriction—is it hormesis? BELLE Newsletter, March 2000

Glade, M. J. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00478-0 · Cited by 6 · see citing works

Present State of Hemorheology

Lechner, H., Ott, E., & Schmidt, R. (2009) · Gerontology · doi:10.1159/000212887 · Cited by 6 · see citing works

Acetyl-L-carnitine.

(1999) · PubMed · Cited by 5 · see citing works

Cerebral Metabolism in Aging and Neurological Disorders

(1987) · KARGER eBooks · doi:10.1159/isbn.978-3-318-01785-4 · Cited by 2 · see citing works

Calcium and neurodegeneration

Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751 · see citing works

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

Davis, J. M., Murphy, E. A., Carmichael, M. D., & Davis, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90925.2008 · Cited by 486 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

Akter, K., Lanza, E. A., Martin, S. A., Myronyuk, N., Rua, M., & Raffa, R. B. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03830.x · Cited by 352 · see citing works

Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria

Irwin, R. W., Yao, J., Hamilton, R. T., Cadenas, E., Brinton, R. D., & Nilsen, J. (2008) · Endocrinology · doi:10.1210/en.2007-1227 · Cited by 289 · see citing works

Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration: Exercise neuroprotection in chronic parkinsonism

Lau, Y.-S., Patki, G., Das-Panja, K., Le, W.-D., & Ahmad, S. O. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07626.x · Cited by 275 · see citing works

Protection from mitochondrial complex II inhibition <i>in vitro</i> and <i>in vivo</i> by Nrf2-mediated transcription

Calkins, M. J., Jakel, R. J., Johnson, D. A., Chan, K., Kan, Y. W., & Johnson, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408487101 · Cited by 247 · see citing works

The Energetics of Huntington's Disease

Browne, S. E., & Beal, M. F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014824.04728.dd · Cited by 240 · see citing works

Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure

Moreira, P. I., Santos, M. S., Moreno, A. M., Seiça, R., & Oliveira, C. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1449 · Cited by 117 · see citing works

Anxiety- and depressive-like behaviors are associated with altered hippocampal energy and inflammatory status in a mouse model of Crohn's disease

Haj-Mirzaian, A., Amiri, S., Amini-Khoei, H., Hosseini, M.-J., Haj-Mirzaian, A., Momeny, M., Rahimi-Balaei, M., & Dehpour, A. R. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.023 · Cited by 100 · see citing works

Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

Castro, J. P., Wardelmann, K., Grune, T., & Kleinridders, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00196 · Cited by 53 · see citing works

Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain

Réus, G. Z., Stringari, R. B., Rezin, G. T., Fraga, D. B., Daufenbach, J. F., Scaini, G., Benedet, J., Rochi, N., Streck, E. L., & Quevedo, J. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0718-2 · Cited by 23 · see citing works

Mitochondrial dysfunction in the striatum of aged chronic mouse model of Parkinson’s disease

Patki, G. (2009) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.003.2009 · Cited by 20 · see citing works

Diagnosis and molecular basis of mitochondrial respiratory chain disorders: Exome sequencing for disease gene identification

Ohtake, A., Murayama, K., Mori, M., Harashima, H., Yamazaki, T., Tamaru, S., Yamashita, Y., Kishita, Y., Nakachi, Y., Kohda, M., et al. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.025 · Cited by 59 · see citing works

Clinical features of mitochondrial disease in a family

Macarrón, C. P.-C., Leon, M. D., Fernández, L., et al. (2015) · Journal of Pediatric Neurology · doi:10.1055/s-0035-1557279

Genetic defects causing mitochondrial respiratory chain disorders and disease

Christodoulou, J. (2000) · Human Reproduction · doi:10.1093/humrep/15.suppl_2.28 · Cited by 34 · see citing works

Spectrum of combined respiratory chain defects

Mayr, J., Haack, T., Freisinger, P., Karall, D., Makowski, C., Koch, J., Feichtinger, R., Zimmermann, F., Rolinski, B., Ahting, U., et al. (2015) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9831-y · Cited by 114 · see citing works

Mitochondrial Disorders

Münnich, A., de Lonlay, P., Rötig, A., et al. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0643-7.00057-7 · Cited by 1 · see citing works