Anaplerotic sequences in microbial metabolism
Abstract
Abstract In addition to catabolic and anabolic pathways, which enable nutrients to enter and to be withdrawn from the central routes of metabolism, enzymic sequences operate to ensure that intermediates, removed from these central routes in the course of biosynthesis, are replenished. These obligatory pathways of replenishment are generically designated “anaplerotic sequences”. The nature of these sequences, operative in micro‐organisms growing on C3‐ and C2‐compounds, is discussed in outline, and the mode of regulation of one of them (the glyoxylate cycle) is examined in detail.
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Because the TCA cycle functions in both catabolic and anabolic capacities, it is considered an amphibolic pathway.
“Because the TCA cycle functions in both catabolic and anabolic capacities, it is considered an amphibolic pathway (7, 8).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [7]
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Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
“Because the TCA cycle functions in both catabolic and anabolic capacities, it is considered an amphibolic pathway (7, 8).”
BackgroundIns and outs of the TCA cycle: the central role of anaplerosis
Inigo, M., Deja, S., & Burgess, S. C. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120420-025558 · Cited by 189 · see citing works
- Authors
- Kornberg, H. L.
- Affiliations
- University of Leicester (GB)
- Corresponding author
- Kornberg, H. L.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1965-07
- Volume
- 4
- Issue
- 7
- Pages
- 558-565
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2169259389
- Cited by
- 90
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 6 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition in English (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- microbial metabolism, glyoxylate cycle, metabolic regulation, central carbon metabolism, biosynthetic intermediates
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