Ins and outs of the TCA cycle: the central role of anaplerosis
Abstract
The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can facilitate the oxidation of an infinite number of nutrient molecules. However, TCA cycle intermediates can be lost to cataplerotic pathways that provide precursors for biosynthesis, and they must be replaced by anaplerotic pathways that regenerate these intermediates. Together, anaplerosis and cataplerosis help regulate rates of biosynthesis by dictating precursor supply, and they play underappreciated roles in catabolism and cellular energy status. They facilitate recycling pathways and nitrogen trafficking necessary for catabolism, and they influence redox state and oxidative capacity by altering TCA cycle intermediate concentrations. These functions vary widely by tissue and play emerging roles in disease. This article reviews the roles of anaplerosis and cataplerosis in various tissues and discusses how they alter carbon transitions, and highlights their contribution to mechanisms of disease.
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Several chemical intermediates of the TCA cycle serve as critical precursors for biosynthetic reactions.
“However, several chemical intermediates of the TCA cycle also serve as critical precursors for biosynthetic reactions, which we will discuss in detail later (5, 6).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [5]
Propionyl-CoA is converted to succinyl-CoA through a pathway involving propionyl-CoA carboxylase and methylmalonyl-CoA mutase.
“Rather, propionyl-CoA is converted to the TCA cycle intermediate succinyl-CoA through a pathway involving propionyl-CoA carboxylase and methylmalonyl-CoA mutase (5).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [5]
Phenylalanine and tyrosine are directly converted to fumarate by fumarylacetoacetate hydratase, providing an alternative entry point for amino acids into the TCA cycle.
“A similar alternative entry point for amino acids into the TCA cycle is direct conversion of phenylalanine and tyrosine to fumarate by fumarylacetoacetate hydratase (5).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [5]
Cites
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works
Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works
Glucose feeds the TCA cycle via circulating lactate
Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., et al. (2017) · Nature · doi:10.1038/nature24057 · Cited by 1,721 · see citing works
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
Pietrocola, F., Galluzzi, L., Pedro, J. M. B., Madeo, F., & Kroemer, G. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.014 · Cited by 1,349 · see citing works
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328 · see citing works
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
Chen, Z., Tian, R., She, Z., Cai, J., & Li, H. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.025 · Cited by 1,303 · see citing works
The key role of anaplerosis and cataplerosis for citric acid cycle function
Owen, O. E., Kalhan, S. C., & Hanson, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200006200 · Cited by 1,172 · see citing works
Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
Ferrannini, E., Muscelli, E., Frascerra, S., Baldi, S., Mari, A., Heise, T., Broedl, U. C., & Woerle, H.-J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72227 · Cited by 1,134 · see citing works
Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069 · see citing works
Neinast, M. D., Murashige, D., & Arany, Z. P. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114455 · Cited by 727 · see citing works
Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.012 · Cited by 719 · see citing works
Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672 · see citing works
Comprehensive quantification of fuel use by the failing and nonfailing human heart
Murashige, D., Jang, C., Neinast, M., Edwards, J. J., Cowan, A., Hyman, M. C., Rabinowitz, J. D., Frankel, D. S., & Arany, Z. (2020) · Science · doi:10.1126/science.abc8861 · Cited by 580 · see citing works
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
Veech, R. L., Eggleston, L. V., & Krebs, H. A. (1969) · Biochemical Journal · doi:10.1042/bj1150609a · Cited by 563 · see citing works
Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions
Antoniewicz, M. R., Kelleher, J. K., & Stephanopoulos, G. N. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.09.001 · Cited by 544 · see citing works
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Neinast, M. D., Jang, C., Hui, S. T., Murashige, D., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.013 · Cited by 500 · see citing works
Biosynthesis of heme in mammals
Ajioka, R. S., Phillips, J. D., & Kushner, J. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.005 · Cited by 493 · see citing works
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Cheng, T., Sudderth, J., Yang, C., Mullen, A. R., Jin, E. S., Matés, J. M., & DeBerardinis, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016627108 · Cited by 475 · see citing works
Utter, M. F., & KEECH, D. B. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67873-1 · Cited by 440 · see citing works
Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K., & Zhao, S. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.028 · Cited by 415 · see citing works
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver
Satapati, S., Kucejová, B., Duarte, J. A. G., Fletcher, J. A., Reynolds, L., Sunny, N. E., He, T., Nair, L. A., Livingston, K. A., Fu, X., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82204 · Cited by 400 · see citing works
INCA: a computational platform for isotopically non-stationary metabolic flux analysis
Young, J. D. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu015 · Cited by 398 · see citing works
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works
Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.
WILLIAMSON, J. R., Kreisberg, R. A., & Felts, P. W. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.1.247 · Cited by 390 · see citing works
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle
Frederick, D. W., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I. M., Quinn, W. J., Gosai, S. J., Tichy, E. D., Davis, J. G., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.005 · Cited by 367 · see citing works
Valera, A., Pujol, A., Pelegrín, M., & Bosch, F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9151 · Cited by 297 · see citing works
The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
Chen, X., Iqbal, N., & Boden, G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5479 · Cited by 291 · see citing works
Rebrin, K., Steil, G. M., Mittelman, S. D., & Bergman, R. N. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118846 · Cited by 288 · see citing works
Roden, M., Stingl, H., Chandramouli, V, Schumann, W. C., Hofer, A., Landau, B. R., Nowotny, P., Waldhäusl, W., & Shulman, G. I. (2000) · Diabetes · doi:10.2337/diabetes.49.5.701 · Cited by 288 · see citing works
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis
Cardaci, S., Zheng, L., MacKay, G., van den Broek, N. J. F., MacKenzie, E. D., Nixon, C., Stevenson, D., Tumanov, S., Bulusu, V., Kamphorst, J. J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3233 · Cited by 286 · see citing works
Kolwicz, S. C., Olson, D. P., Marney, L. C., Garcia‐Menendez, L., Synovec, R. E., & Tian, R. (2012) · Circulation Research · doi:10.1161/circresaha.112.268128 · Cited by 284 · see citing works
Burgess, S. C., He, T.-T., Yan, Z., Lindner, J., Sherry, A. D., Malloy, C. R., Browning, J. D., & Magnuson, M. A. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.004 · Cited by 276 · see citing works
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth
Montal, E. D., Dewi, R. E., Bhalla, K., Ou, L., Hwang, B. J., Ropell, A. E., Gordon, C. R., Liu, W.-J., DeBerardinis, R. J., Sudderth, J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.025 · Cited by 261 · see citing works
Metabolic cycling in control of glucose-stimulated insulin secretion
Jensen, M. V., Joseph, J. W., Ronnebaum, S. M., Burgess, S. C., Sherry, A. D., & Newgard, C. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90604.2008 · Cited by 257 · see citing works
Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I., & Yki‐Järvinen, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922344117 · Cited by 253 · see citing works
Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Iñigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.014 · Cited by 242 · see citing works
The fate of isotopic carbon in kidney cortex synthesizing glucose from lactate
Krebs, H., Hems, R., Weidemann, M. J., & Speake, R. N. (1966) · Biochemical Journal · doi:10.1042/bj1010242 · Cited by 218 · see citing works
Chakravarty, K., Cassuto, H., Reshef, L., & Hanson, R. W. (2005) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230590935479 · Cited by 217 · see citing works
Neuroglial Metabolism in the Awake Rat Brain: CO2Fixation Increases with Brain Activity
Öz, G., Berkich, D. A., Henry, P., Xu, Y., LaNoue, K. F., Hutson, S. M., & Rolf Gruetter, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3564-04.2004 · Cited by 215 · see citing works
Liu, M., Jin, L., Sun, S.-J., Liu, P., Feng, X., Cheng, Z., Liu, W., Guan, K., Shi, Y., Yuan, H., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0070-6 · Cited by 213 · see citing works
McCommis, K. S., Chen, Z., Fu, X., McDonald, W. G., Colca, J. R., Kletzien, R. F., Burgess, S. C., & Finck, B. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.028 · Cited by 210 · see citing works
PCK1 and PCK2 as candidate diabetes and obesity genes
BEALE, E. G., Harvey, B. J., & Forest, C. D. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0025-6 · Cited by 209 · see citing works
Consoli, A., Nurjhan, N., Reilly, J. J., Bier, D. M., & Gerich, J. E. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114940 · Cited by 204 · see citing works
Hakimi, P., Yang, J., Casadesús, G., Massillon, D., Tolentino‐Silva, F., Nye, C. K., Cabrera, M. E., Hagen, D., Utter, C. B., Baghdy, Y., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706127200 · Cited by 200 · see citing works
Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia
Cotter, D. G., Erçal, B., Huang, X., Leid, J. M., d’Avignon, D. A., Graham, M. J., Dietzen, D. J., Brunt, E. M., Patti, G. J., & Crawford, P. A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76388 · Cited by 199 · see citing works
Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver
Fletcher, J. A., Deja, S., Satapati, S., Fu, X., Burgess, S. C., & Browning, J. D. (2019) · JCI Insight · doi:10.1172/jci.insight.127737 · Cited by 195 · see citing works
Groen, A. K., van Roermund, C. W. T., Vervoorn, R. C., & Tager, J. M. (1986) · Biochemical Journal · doi:10.1042/bj2370379 · Cited by 184 · see citing works
Burgess, S. C., Hausler, N., Merritt, M. E., Jeffrey, F. M. H., Storey, C. J., Milde, A., Koshy, S., Lindner, J., Magnuson, M. A., Malloy, C. R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407120200 · Cited by 178 · see citing works
Samuel, V. T., Beddow, S. A., Iwasaki, T., Zhang, X., Chu, X., Still, C. D., Gerhard, G. S., & Shulman, G. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812547106 · Cited by 176 · see citing works
Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity
Stümvoll, M., Meyer, C., Perriello, G., Kreider, M. E., Welle, S. L., & Gerich, J. E. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.5.e817 · Cited by 173 · see citing works
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism
Dai, W., Xu, L., Yu, X., Zhang, G., Guo, H., Liu, H., Song, G., Weng, S., Dong, L., Zhu, J., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.12.015 · Cited by 173 · see citing works
Krebs, H. A., & Veech, R. L. (1969) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(69)90030-2 · Cited by 170 · see citing works
Consoli, A., Kennedy, F., Miles, J., & Gerich, J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113206 · Cited by 170 · see citing works
Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
Titchenell, P. M., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Nature Communications · doi:10.1038/ncomms8078 · Cited by 169 · see citing works
Anaplerosis of the citric acid cycle: role in energy metabolism of heart and skeletal muscle
Gibala, M. J., Young, M. E., & Taegtmeyer, H. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00717.x · Cited by 169 · see citing works
Alterations of Mitochondrial Function and Insulin Sensitivity in Human Obesity and Diabetes Mellitus
Koliaki, C. C., & Roden, M. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050656 · Cited by 167 · see citing works
Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M., & Tanaka, T. (2018) · Kidney International · doi:10.1016/j.kint.2018.04.025 · Cited by 167 · see citing works
Browning, J. D., Baxter, J., Satapati, S., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p020867 · Cited by 160 · see citing works
Metabolic consequences of oncogenic IDH mutations
Parker, S. J., & Metallo, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.003 · Cited by 158 · see citing works
Pound, K. M., Sorokina, N., Ballal, K., Berkich, D. A., Fasano, M., LaNoue, K. F., Taegtmeyer, H., O’Donnell, J. M., & Lewandowski, E. D. (2009) · Circulation Research · doi:10.1161/circresaha.108.189951 · Cited by 157 · see citing works
Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
Kumashiro, N., Beddow, S. A., Vatner, D. F., Majumdar, S. K., Cantley, J. L., Guebre‐Egziabher, F., Fat, I., Guigni, B. A., Jurczak, M. J., Birkenfeld, A. L., et al. (2013) · Diabetes · doi:10.2337/db12-1311 · Cited by 153 · see citing works
Noninvasive tracing of Krebs cycle metabolism in liver.
Magnusson, I., Schumann, W. C., Bartsch, G. E., Chandramouli, V., Kumaran, K., Wahren, J., & Landau, B. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89598-2 · Cited by 152 · see citing works
Inborn and acquired metabolic defects in cancer
Frezza, C., Pollard, P. J., & Gottlieb, E. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0728-4 · Cited by 146 · see citing works
Mitochondrial pyruvate carriers are required for myocardial stress adaptation
Zhang, Y., Taufalele, P., Cochran, J. D., Frayne, I. R., Marx, J. M., Soto, J. E., Rauckhorst, A. J., Tayyari, F., Pewa, A. D., Gray, L. R., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00288-1 · Cited by 138 · see citing works
Pyruvate carboxylase deficiency: Mechanisms, mimics and anaplerosis
Marin‐Valencia, I., Roe, C. R., & Pascual, J. M. (2010) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2010.05.004 · Cited by 133 · see citing works
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
Alves, T. C., Pongratz, R. L., Zhao, X., Yarborough, O. H., Sereda, S., Shirihai, O. S., Cline, G. W., Mason, G. F., & Kibbey, R. G. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.021 · Cited by 129 · see citing works
Sources of carbon for hepatic glycogen synthesis in the conscious dog.
Moore, M. C., Cherrington, A. D., Cline, G. W., Pagliassotti, M. J., Jones, E. M., Neal, D. W., Badet, C., & Shulman, G. I. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115342 · Cited by 127 · see citing works
Gómez-Valadés, A. G., Méndez‐Lucas, A., Vidal‐Alabró, A., Blasco, F. X., Chillón, M., Bartrons, R., Bermúdez, J., & Perales, J. C. (2008) · Diabetes · doi:10.2337/db07-1087 · Cited by 123 · see citing works
Chevalier, S., Burgess, S. C., Malloy, C. R., Gougeon, R., Marliss, E. B., & Morais, J. A. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-1117 · Cited by 121 · see citing works
Isotopomer studies of gluconeogenesis and the Krebs cycle with 13C-labeled lactate.
Katz, J. J., Wals, P. A., & Lee, W. N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74421-4 · Cited by 120 · see citing works
Isotopomer Analysis of Citric Acid Cycle and Gluconeogenesis in Rat Liver
Rosiers, C. D., Donato, L. D., Comte, B., Laplante, A., Marcoux, C., David, F., Fernandez, C. A., & Brunengraber, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10027 · Cited by 114 · see citing works
PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis
Méndez‐Lucas, A., Duarte, J. A. G., Sunny, N. E., Satapati, S., He, T., Fu, X., Bermúdez, J., Burgess, S. C., & Perales, J. C. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.020 · Cited by 114 · see citing works
Burgess, S. C., Leone, T. C., Wende, A. R., Croce, M. A., Chen, Z., Sherry, A. D., Malloy, C. R., & Finck, B. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600050200 · Cited by 111 · see citing works
Exercise Combats Hepatic Steatosis: Potential Mechanisms and Clinical Implications
Thyfault, J. P., & Rector, R. S. (2020) · Diabetes · doi:10.2337/dbi18-0043 · Cited by 111 · see citing works
Stark, R., Guebre‐Egziabher, F., Zhao, X., Feriod, C. N., Dong, J., Alves, T. C., Ioja, S., Pongratz, R. L., Bhanot, S., Roden, M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.544759 · Cited by 110 · see citing works
Pathophysiology of propionic and methylmalonic acidemias. Part 1: Complications
Haijes, H. A., Jans, J. J. M., Tas, S. Y., Verhoeven‐Duif, N. M., & van Hasselt, P. M. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12129 · Cited by 109 · see citing works
Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo
Ramnanan, C. J., Edgerton, D. S., Rivera, N., Irimia, J. M., Farmer, B., Neal, D. W., Lautz, M., Donahue, E. P., Meyer, C. M., Roach, P. J., et al. (2010) · Diabetes · doi:10.2337/db09-1625 · Cited by 106 · see citing works
APOE alters glucose flux through central carbon pathways in astrocytes
Williams, H. C., Farmer, B. C., Piron, M. A., Walsh, A. E., Bruntz, R. C., Gentry, M. S., Sun, R. C., & Johnson, L. A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104742 · Cited by 105 · see citing works
Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells
Crown, S. B., Ahn, W. S., & Antoniewicz, M. R. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-43 · Cited by 99 · see citing works
Befroy, D. E., Perry, R. J., Jain, N., Dufour, S., Cline, G. W., Trimmer, J. K., Brosnan, J. M., Rothman, D. L., Petersen, K. F., & Shulman, G. I. (2013) · Nature Medicine · doi:10.1038/nm.3415 · Cited by 95 · see citing works
Tracing insights into de novo lipogenesis in liver and adipose tissues
Wallace, M., & Metallo, C. M. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.02.012 · Cited by 94 · see citing works
Rat Liver Pyruvate Carboxylase
McClure, W. R., & Lardy, H. A. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62170-2 · Cited by 93 · see citing works
Jones, J. G., Naidoo, R., Sherry, A. D., Jeffrey, F. M. H., Cottam, G. L., & Malloy, C. R. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00764-3 · Cited by 92 · see citing works
Burch, J. S., Marcero, J. R., Maschek, J. A., Cox, J. E., Jackson, L. K., Medlock, A. E., Phillips, J. D., & Dailey, H. A. (2018) · Blood · doi:10.1182/blood-2018-01-829036 · Cited by 92 · see citing works
Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo
Edgerton, D. S., Ramnanan, C. J., Grueter, C. A., Johnson, K., Lautz, M., Neal, D. W., Williams, P. E., & Cherrington, A. D. (2009) · Diabetes · doi:10.2337/db09-0328 · Cited by 91 · see citing works
INCORPORATION OF ACETATE CARBON INTO GLUCOSE BY LIVER SLICES FROM NORMAL AND ALLOXAN-DIABETIC RATS
Strisower, E. H., Köhler, G., & Chaikoff, I. L. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55562-9 · Cited by 90 · see citing works
Anaplerotic sequences in microbial metabolism
Kornberg, H. L. (1965) · Angewandte Chemie International Edition in English · doi:10.1002/anie.196505581 · Cited by 90 · see citing works
Amaral, A. I., Hadera, M. G., Tavares, J. M., Kotter, M., & Sonnewald, U. (2015) · Glia · doi:10.1002/glia.22900 · Cited by 88 · see citing works
Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome
d’Avignon, D. A., Puchalska, P., Erçal, B., Chang, Y., Martin, S. E., Graham, M. J., Patti, G. J., Han, X., & Crawford, P. A. (2018) · JCI Insight · doi:10.1172/jci.insight.99762 · Cited by 88 · see citing works
Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine
Dozin, B., Magnuson, M. A., & Nikodem, V. M. (1985) · Biochemistry · doi:10.1021/bi00341a044 · Cited by 86 · see citing works
Bowtell, J. L., Marwood, S., Bruce, M., Constantin-Teodosiu, D., & Greenhaff, P. L. (2007) · Sports Medicine · doi:10.2165/00007256-200737120-00005 · Cited by 81 · see citing works
Zhang, W., Bu, S. Y., Mashek, M. T., O‐Sullivan, I., Sibai, Z., Khan, S. A., Ilkayeva, O., Newgard, C. B., Mashek, D. G., & Unterman, T. G. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.021 · Cited by 80 · see citing works
Rauckhorst, A. J., Gray, L. R., Sheldon, R. D., Fu, X., Pewa, A. D., Feddersen, C. R., Dupuy, A. J., Gibson-Corley, K. N., Cox, J. E., Burgess, S. C., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.002 · Cited by 74 · see citing works
Nonhepatic glucose production in humans
Battezzati, A., Caumo, A., Martino, F. K., Sereni, L. P., Coppa, J. C., Romito, R., Ammatuna, M., Regalia, E., Matthews, D. E., Mazzaferro, V., et al. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00486.2002 · Cited by 72 · see citing works
Morken, T. S., Brekke, E., Haberg, A. K., Widerøe, M., Brubakk, A., & Sonnewald, U. (2014) · Stroke · doi:10.1161/strokeaha.114.005341 · Cited by 70 · see citing works
Acute intermittent porphyria causes hepatic mitochondrial energetic failure in a mouse model
Homedan, C., Laafi, J., Schmitt, C., Guéguen, N., Lefèbvre, T., Karim, Z., Desquiret‐Dumas, V., Wetterwald, C., Deybach, J., Gouya, L., et al. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.032 · Cited by 70 · see citing works
Lee, W. D., Mukha, D., Aizenshtein, E., & Shlomi, T. (2019) · Nature Communications · doi:10.1038/s41467-019-09352-1 · Cited by 70 · see citing works
Latorre‐Muro, P., Baeza, J., Armstrong, E. A., Hurtado‐Guerrero, R., Corzana, F., Wu, L. E., Sinclair, D. A., López‐Buesa, P., Carrodeguas, J. A., & Denu, J. M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.031 · Cited by 68 · see citing works
Leithner, K., Triebl, A., Trötzmüller, M., Hinteregger, B., Leko, P., Wieser, B. I., Grasmann, G., Bertsch, A., Züllig, T., Stacher, E., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719871115 · Cited by 67 · see citing works
AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects
Fischer, H., Esbjörnsson, M., Sabina, R. L., Strömberg, A., Peyrard‐Janvid, M., & Norman, B. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00185.2007 · Cited by 63 · see citing works
Astrocytic pyruvate carboxylation: Status after 35 years
Schousboe, A., Waagepetersen, H. S., & Sonnewald, U. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24402 · Cited by 63 · see citing works
Goedeke, L., Peng, L., Montalvo-Romeral, V., Butrico, G. M., Dufour, S., Zhang, X., Perry, R. J., Cline, G. W., Kievit, P., Chng, K., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0284 · Cited by 63 · see citing works
Sherry, A. D., Jeffrey, F. M. H., & Malloy, C. R. (2003) · Metabolic Engineering · doi:10.1016/j.ymben.2003.10.007 · Cited by 62 · see citing works
Stationary versus non-stationary 13C-MFA: A comparison using a consistent dataset
Noack, S., Nöh, K., Moch, M., Oldiges, M., & Wiechert, W. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.07.008 · Cited by 62 · see citing works
Wang, Y., Kwon, H., Su, X., & Wondisford, F. E. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.005 · Cited by 61 · see citing works
Tracking the carbons supplying gluconeogenesis
Shah, A. M., & Wondisford, F. E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.012758 · Cited by 61 · see citing works
Jesinkey, S. R., Madiraju, A. K., Alves, T. C., Yarborough, O. H., CARDONE, R. L., Zhao, X., Parsaei, Y., Nasiri, A. R., Butrico, G. M., Liu, X., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.058 · Cited by 60 · see citing works
Hughey, C. C., James, F. D., Bracy, D. P., Donahue, E. P., Young, J. D., Viollet, B., Foretz, M., & Wasserman, D. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.811547 · Cited by 59 · see citing works
Vily‐Petit, J., Soty, M., Silva, M., Raffin, M., Gautier‐Stein, A., Rajas, F., & Mithieux, G. (2020) · Gut · doi:10.1136/gutjnl-2019-319745 · Cited by 57 · see citing works
Novak, C. M., Escande, C., Gerber, S. M., Chini, E. N., Zhang, M., Britton, S. L., Koch, L. G., & Levine, J. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005869 · Cited by 54 · see citing works
Functional Consequences of Metabolic Zonation in Murine Livers: Insights for an Old Story
Berndt, N., Kolbe, E., Gajowski, R., Eckstein, J., Ott, F., Meierhofer, D., Holzhütter, H., & Matz‐Soja, M. (2020) · Hepatology · doi:10.1002/hep.31274 · Cited by 54 · see citing works
Estimation of pyruvate recycling during gluconeogenesis in perfused rat liver
Friedmann, B., GOODMAN, E. H., Saunders, H. L., Kostos, V., & Weinhouse, S. (1971) · Metabolism · doi:10.1016/0026-0495(71)90055-2 · Cited by 53 · see citing works
Karaca, M., Martin-Levilain, J., Grimaldi, M., Li, L., Dizin, É., Emre, Y., & Maechler, P. (2018) · Diabetes · doi:10.2337/db17-1561 · Cited by 52 · see citing works
Montal, E. D., Bhalla, K., Dewi, R. E., Ruiz, C. F., Haley, J. D., Ropell, A. E., Gordon, C. R., Haley, J. D., & Girnun, G. D. (2019) · Cancer & Metabolism · doi:10.1186/s40170-019-0199-6 · Cited by 50 · see citing works
Mitochondrial phosphoenolpyruvate carboxykinase deficiency
Clayton, P. T., Hyland, Κ., Brand, M. P., & Leonard, J. V. (1986) · European Journal of Pediatrics · doi:10.1007/bf00441851 · Cited by 48 · see citing works
Tracing Hepatic Gluconeogenesis Relative to Citric Acid Cycle Activity in Vitro and in Vivo
Beylot, M., Soloviev, M. V., David, F., Landau, B. R., & Brunengraber, H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1509 · Cited by 46 · see citing works
Hasenour, C. M., Rahim, M., & Young, J. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107986 · Cited by 46 · see citing works
Is There Glucose Production Outside of the Liver and Kidney?
Previs, S. F., Brunengraber, D. Z., & Brunengraber, H. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141134 · Cited by 45 · see citing works
Lahey, R., Carley, A. N., Wang, X., Glass, C. E., Accola, K., Silvestry, S., O’Donnell, J. M., & Lewandowski, E. D. (2018) · Circulation Research · doi:10.1161/circresaha.118.312660 · Cited by 45 · see citing works
Landau, B. R., Schumann, W. C., Chandramouli, V., Magnusson, I., Kumaran, K., & Wahren, J. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.4.e636 · Cited by 44 · see citing works
Jones, J. G., Solomon, M. A., Sherry, A. D., Jeffrey, F. M. H., & Malloy, C. R. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e843 · Cited by 44 · see citing works
Mazuel, L., Blanc, J., Repond, C., Bouchaud, V., Raffard, G., Déglon, N., Bonvento, G., Pellerin, L., & Bouzier-Sore, A.-K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174990 · Cited by 44 · see citing works
Browning, J. D., Weis, B. C., Davis, J., Satapati, S., Merritt, M. E., Malloy, C. R., & Burgess, S. C. (2008) · Hepatology · doi:10.1002/hep.22504 · Cited by 43 · see citing works
Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice
Jia, Y., He, J., Wang, L., Su, L., Lei, L., Huang, W., Geng, X., Zhang, S., Meng, X., Zhou, H., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487783 · Cited by 43 · see citing works
Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA
Adina-Zada, A., Zeczycki, T. N., Maurice, M. S., Jitrapakdee, S., Cleland, W. W., & Attwood, P. V. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120041 · Cited by 42 · see citing works
Peoc’h, K., Nicolas, G., Schmitt, C., Mirmiran, A., Daher, R., Lefèbvre, T., Gouya, L., Karim, Z., & Puy, H. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.01.015 · Cited by 42 · see citing works
Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis
Álvarez, Z., Hyroššová, P., Perales, J. C., & Alcántara, S. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu281 · Cited by 41 · see citing works
Vieira, P., Cameron, J. M., Rahikkala, E., Keski‐Filppula, R., Zhang, L., Santra, S., Matthews, A., Myllynen, P. K., Nuutinen, M., Moilanen, J. S., et al. (2017) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2017.02.003 · Cited by 40 · see citing works
Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism
McCommis, K. S., & Finck, B. N. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.09.017 · Cited by 39 · see citing works
Bergman, R. N., & Iyer, M. S. (2017) · Diabetes · doi:10.2337/db16-1320 · Cited by 38 · see citing works
Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity
Kucejová, B., Duarte, J. A. G., Satapati, S., Fu, X., Ilkayeva, O., Newgard, C. B., Brugarolas, J., & Burgess, S. C. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.006 · Cited by 37 · see citing works
Gluconeogenesis from labeled carbon: estimating isotope dilution
Kelleher, J. K. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.250.3.e296 · Cited by 36 · see citing works
Egnatchik, R. A., Leamy, A. K., Sacco, S. A., Cheah, Y. E., Shiota, M., & Young, J. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004869 · Cited by 35 · see citing works
Arinze, I. (2005) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.2005.494033032469 · Cited by 33 · see citing works
Deja, S., Fu, X., Fletcher, J. A., Kucejová, B., Browning, J. D., Young, J. D., & Burgess, S. C. (2019) · Metabolic Engineering · doi:10.1016/j.ymben.2019.12.005 · Cited by 28 · see citing works
Peng, R., Zhang, M., Wang, H., Lin, J., Wang, H., Wang, F., Liu, L., Zhao, Q., & Liu, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105132 · Cited by 26 · see citing works
Regulation of pyruvate carboxylation by acetyl‐CoA in rat liver mitochondria
von Glutz, G., & Walter, P. (1976) · FEBS Letters · doi:10.1016/0014-5793(76)80991-x · Cited by 25 · see citing works
Owczarek, A., Gieczewska, K. B., Jarzyna, R., Jagielski, A. K., Kiersztan, A., Gruza, A., & Winiarska, K. (2020) · Biochimie · doi:10.1016/j.biochi.2020.02.002 · Cited by 25 · see citing works
Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine
Potts, A., Uchida, A., Deja, S., Berglund, E. D., Kucejová, B., Duarte, J. A. G., Fu, X., Browning, J. D., Magnuson, M. A., & Burgess, S. C. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00039.2018 · Cited by 24 · see citing works
Søvik, O. (1989) · Acta Paediatrica · doi:10.1111/j.1651-2227.1989.tb11052.x · Cited by 21 · see citing works
Remodeling of substrate consumption in the murine sTAC model of heart failure
Turer, A. T., Altamirano, F. J., Schiattarella, G. G., May, H. I., Gillette, T. G., Malloy, C. R., & Merritt, M. E. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.07.007 · Cited by 21 · see citing works
Therapeutic potential of triheptanoin in metabolic and neurodegenerative diseases
Wehbe, Z., & Tucci, S. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12199 · Cited by 21 · see citing works
Haeme-regulated Degradation of -Aminolevulinate Synthase 1 in Rat Liver Mitochondria
Yoshino, K., Munakata, H., Kuge, O., Ito, A., & Ogishima, T. (2007) · The Journal of Biochemistry · doi:10.1093/jb/mvm159 · Cited by 20 · see citing works
Metabolomics applied to islet nutrient sensing mechanisms
Jensen, M. V., Gooding, J. R., Ferdaoussi, M., Dai, X., Peterson, B. S., MacDonald, P. E., & Newgard, C. B. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13010 · Cited by 17 · see citing works
Mendes, A. C., Caldeira, M. M., Silva, C., Burgess, S. C., Merritt, M. E., Coreta-Gomes, F. M., Barosa, C., Delgado, T. C., Franco, F., Monteiro, P. F., et al. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21057 · Cited by 16 · see citing works
Twenty-seven Years of Cerebral Pyruvate Recycling
Cerdán, S. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2173-4 · Cited by 16 · see citing works
Alger, J. R., Sherry, A. D., & Malloy, C. R. (2018) · Current Metabolomics · doi:10.2174/2213235x07666181219115856 · Cited by 15 · see citing works
Walton, M., Ebert, D. J., & Haller, R. G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.033761 · Cited by 15 · see citing works
Active pyruvate dehydrogenase and impaired gluconeogenesis in orthotopic hepatomas of rats
Lee, M. H., DeBerardinis, R. J., Wen, X., Corbin, I. R., Sherry, A. D., Malloy, C. R., & Jin, E. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153993 · Cited by 13 · see citing works
Yuan, X., Wang, L., Tandon, N., Sun, H., Tian, J., Du, H., Pascual, J. M., & Guo, L. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200594 · Cited by 12 · see citing works
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Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Monzel, A. S., Enrı́quez, J. A., & Picard, M. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00783-1 · Cited by 618 · see citing works
Regulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
“However, several chemical intermediates of the TCA cycle also serve as critical precursors for biosynthetic reactions, which we will discuss in detail later (5, 6).”
BackgroundInfluentialBrown Adipose Tissue—A Translational Perspective
Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 202 · see citing works
The mTORC2 signaling network: targets and cross-talks
Ragupathi, A., Kim, C., & Jacinto, E. (2024) · Biochemical Journal · doi:10.1042/bcj20220325 · Cited by 113 · see citing works
Midha, A. D., Zhou, Y., Queliconi, B. B., Barrios, A. M., Haribowo, A. G., Chew, B. T. L., Fong, C. O. Y., Blecha, J. E., VanBrocklin, H. F., Seo, Y., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.007 · Cited by 88 · see citing works
Multifaceted mitochondria in innate immunity
Marques, E., Kramer, R., & Ryan, D. G. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00008-3 · Cited by 88 · see citing works
Rahim, M., Ragavan, M., Deja, S., Merritt, M. E., Burgess, S. C., & Young, J. D. (2021) · Metabolic Engineering · doi:10.1016/j.ymben.2021.12.009 · Cited by 80 · see citing works
Deja, S., Fletcher, J. A., Kim, C.-W., Kucejová, B., Fu, X., MIZERSKA, M. N., Villegas, M., Pudełko‐Malik, N., Browder, N., Iñigo, M. R., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.004 · Cited by 77 · see citing works
Li, N., Li, Q., He, X., Gao, X., Wu, L., Xiao, M., Cai, W., Liu, B., & Zeng, F. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.008 · Cited by 71 · see citing works
Li, L., & Tian, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114504 · Cited by 73 · see citing works
Engineered mitochondria in diseases: mechanisms, strategies, and applications
Li, M., Wu, L., Si, H., Wu, Y., Liu, Y., Zeng, Y., & Shen, B. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02081-y · Cited by 64 · see citing works
The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy
Wu, J., Liu, N., Chen, J., Tao, Q., Li, Q., Li, J., Chen, X., & Peng, C. (2024) · Research · doi:10.34133/research.0351 · Cited by 57 · see citing works
Thermodynamic principle to enhance enzymatic activity using the substrate affinity
Ooka, H., Chiba, Y., & Nakamura, R. (2023) · Nature Communications · doi:10.1038/s41467-023-40471-y · Cited by 48 · see citing works
Yuan, Y., Liu, L., Guo, L., Wang, L., & Liu, Y. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.116523 · Cited by 47 · see citing works
Kong, L., Yue, Y., Li, J., Yang, B., Chen, B., Liu, J., & Lu, Z. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113240 · Cited by 47 · see citing works
Nandy, A., Helderman, R. C. M., Thapa, S., Jayapalan, S., Richards, A., Narayani, N. A., Czech, M., Rosen, C. J., & Rendina-Ruedy, E. (2023) · Bone Research · doi:10.1038/s41413-023-00297-2 · Cited by 42 · see citing works
Xie, J., Lin, D., Li, J., Zhou, T., Lin, S., & Lin, Z. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1179749 · Cited by 41 · see citing works
Chronic heat stress as a predisposing factor in summer mortality of mussels, Perna canaliculus
Ericson, J. A., Venter, L., Copedo, J. S., Nguyen, T. V., Alfaro, A. C., & Ragg, N. L. C. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738986 · Cited by 38 · see citing works
Jing, J. L., Cheng, T. Y. N., Natali, F., Eisenhaber, F., & Alfatah, M. (2022) · Cells · doi:10.3390/cells11050862 · Cited by 38 · see citing works
Rauckhorst, A. J., Sheldon, R. D., Pape, D. J., Ahmed, A., Falls-Hubert, K. C., Merrill, R. A., Brown, R. F., Deshmukh, K., Vallim, T., Deja, S., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.013 · Cited by 37 · see citing works
Non-canonical and developmental roles of the TCA cycle in plants
Zhang, T., Peng, J. T., Klair, A., & Dickinson, A. J. (2023) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2023.102382 · Cited by 36 · see citing works
Daverio, Z., Balcerczyk, A., Rautureau, G. J. P., & Panthu, B. (2023) · Cancers · doi:10.3390/cancers15051417 · Cited by 35 · see citing works
Algieri, C., Nesci, S., & Oppedisano, F. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07392-4 · Cited by 36 · see citing works
Samsami, H., & Maali-Amiri, R. (2024) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2024.108862 · Cited by 32 · see citing works
Fu, X., Fletcher, J. A., Deja, S., Inigo-Vollmer, M., Burgess, S. C., & Browning, J. D. (2023) · Journal of Clinical Investigation · doi:10.1172/jci167442 · Cited by 30 · see citing works
The flux of energy in critical illness and the obesity paradox
Jaitovich, A., & Hall, J. B. (2025) · Physiological Reviews · doi:10.1152/physrev.00029.2024 · Cited by 33 · see citing works
Kankuri, E. M., Finckenberg, P., Leinonen, J., Tarkia, M., Björk, S., Purhonen, J., Kallijärvi, J., Kankainen, M., Soliymani, R., Lalowski, M. M., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00967-5 · Cited by 32 · see citing works
Hu, S., Heng, H., Yang, F., Wang, M., Liu, G., Xiang, Y., & Miao, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1735873 · Cited by 31 · see citing works
Ammar, N., Hildebrandt, M., Geismann, C., Röder, C., Gemoll, T., Sebens, S., Trauzold, A., & Schäfer, H. (2023) · Antioxidants · doi:10.3390/antiox12101818 · Cited by 27 · see citing works
Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease
Jokinen, M. J., & Luukkonen, P. K. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.02.003 · Cited by 24 · see citing works
Vuillemin, A., Ruiz-Blas, F., Yang, S., Bartholomäus, A., Henny, C., & Kallmeyer, J. (2024) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiae140 · Cited by 24 · see citing works
Quantification of nutrient fluxes during acute exercise in mice
Axsom, J., TeSlaa, T. A., Lee, W. D., Chu, Q., Cowan, A. J., Bornstein, M. R., Neinast, M. D., Bartman, C., Blair, M. C., Li, K., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.010 · Cited by 23 · see citing works
Fumarate integrates metabolism and immunity in diseases
Cheng, J., Xiao, Y., & Jiang, P. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.03.008 · Cited by 23 · see citing works
Peng, H., Zhang, Q., Su, Y. X., Wang, S., & Chen, Y. (2025) · Nature Water · doi:10.1038/s44221-025-00501-z · Cited by 22 · see citing works
Gu, L., Du, Y., Chen, J., Hasan, M. N., Clayton, Y. D., Matye, D. J., Friedman, J. E., & Li, T. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2320934121 · Cited by 22 · see citing works
Chatterjee, B., Fatima, F., Seth, S., & Roy, S. S. (2024) · Cells · doi:10.3390/cells13030214 · Cited by 22 · see citing works
Camus, M. F., Rodríguez, E., Kotiadis, V. N., Carter, H. F., & Lane, N. J. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112158 · Cited by 19 · see citing works
Marin‐Valencia, I., Kocabas, A. M., Rodríguez‐Navas, C., Miloushev, V. Z., González-Rodríguez, M., Lees, H., Henry, K. E., Vaynshteyn, J., Longo, V. A., Deh, K., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.002 · Cited by 19 · see citing works
Antibiofilm mechanism of dielectric barrier discharge cold plasma against Pichia manshurica
Hou, X., Wang, J., Yuan, M., Ge, L., Qian, J., Huang, Y., Yang, M., Li, H., Wang, Y., Yan, Z., et al. (2023) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2023.103340 · Cited by 18 · see citing works
Dankel, S. N., Kalleklev, T., Tungland, S. L., Stafsnes, M. H., Bruheim, P., Aloysius, T. A., Lindquist, C., Skorve, J., Nygard, O. K., Madsen, L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115536 · Cited by 18 · see citing works
The central role of mitochondrial metabolism in hepatic steatosis
Win, S., Than, T. A., Kaplowitz, N., Wong, N., Arya, A., Win, Z. T., Win, S. H., Phyu, E., Kuemerle, C., Suh, J., et al. (2024) · Exploration of Digestive Diseases · doi:10.37349/edd.2024.00039 · Cited by 18 · see citing works
Venter, L., Alfaro, A. C., Ragg, N. L. C., Delorme, N. J., & Ericson, J. A. (2023) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2023.103702 · Cited by 17 · see citing works
Gopal, K., Abdualkader, A. M., Li, X., Greenwell, A. A., Karwi, Q. G., Altamimi, T., Saed, C. T., Uddin, G. M., Darwesh, A. M., Jamieson, K. L., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105375 · Cited by 20 · see citing works
Gondáš, E., Trancikova, A. K., Dibdiaková, K., Galanda, T., Hatok, J., Račay, P., Dobrota, D., & Murín, R. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03856-5 · Cited by 16 · see citing works
Idzikowska, K., Gątarek, P., Gajda, A., Safiński, P., Przysło, Ł., & Kałużna‐Czaplińska, J. (2025) · Nutrients · doi:10.3390/nu17182969 · Cited by 15 · see citing works
Bai, Z., Hu, H.-L., Hu, F., Ji, J., & Ji, Z. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03453-y · Cited by 15 · see citing works
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner, B. P., Joseph, P., Quast, A. F., Ramirez, M. A., Heerdt, P. M., Villalobos, J. G., & Singh, I. (2024) · Pulmonary Circulation · doi:10.1002/pul2.70009 · Cited by 15 · see citing works
Wu, X., Wang, M., Luo, S., Zhou, Z., Wang, Y., Du, G., Chen, J., & Liu, X. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.09.016 · Cited by 14 · see citing works
Molecular Insights of Drug Resistance in Epilepsy: Multi-omics Unveil
Dhureja, M., Chaturvedi, P., Choudhary, A., Kumar, P., & Munshi, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04220-6 · Cited by 13 · see citing works
Lin, Y., Wang, W., Li, J., Ai, Y., Wang, H., Han, Y., Wang, W., & Hou, W. (2024) · LWT · doi:10.1016/j.lwt.2024.116572 · Cited by 13 · see citing works
Fujii, J. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2407147 · Cited by 13 · see citing works
Krebs takes a turn at cell differentiation
Deja, S., Crawford, P. A., & Burgess, S. C. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.005 · Cited by 13 · see citing works
Lin, Z., He, H., Chen, P., Dong, X., Jiang, J., Huang, W., Pan, Z., Guan, Z., Lu, L., Li, H., et al. (2025) · Basic Research in Cardiology · doi:10.1007/s00395-025-01135-8 · Cited by 13 · see citing works
Marques, E., Burr, S. P., Casey, A. M., Stopforth, R. J., Yu, C. S., Turner, K., Wolf, D. M., Dilucca, M., Paupe, V., Chowdhury, S. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65023-4 · Cited by 13 · see citing works
Zhang, Y., Li, X., Zhang, A., Wang, Z., Song, Y., Xie, X., Zhu, W., & Yang, X. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.148649 · Cited by 12 · see citing works
Bogan, J. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1019405 · Cited by 12 · see citing works
Liu, M., Gao, J., Guo, H., Zhu, K.-C., Liu, B.-S., Zhang, N., Sun, J., & Zhang, D. (2023) · Biology · doi:10.3390/biology12091161 · Cited by 12 · see citing works
Redox-dependent liver gluconeogenesis impacts different intensity exercise in mice
Horiuchi, T., Kaneko, K., Hosaka, S., Uno, K., Tomiyama, S., Takahashi, K., Yamato, M., Endo, A., Sugawara, H., Kawana, Y., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01373-z · Cited by 11 · see citing works
Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics
Alhasan, K. A., King, M. A., Pattar, B. S. B., Lewis, I. A., Lopaschuk, G. D., & Greenway, S. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae248 · Cited by 11 · see citing works
Cardiac performance mirrors the passive thermal tolerance range in the oyster Ostrea edulis
Götze, S., Reddin, C. J., Ketelsen, I., Busack, M., Lannig, G., Bock, C., & Pörtner, H. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.249750 · Cited by 11 · see citing works
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review
Mukherjee, A. G., Mishra, S., Gopalakrishnan, A. V., Kannampuzha, S., Murali, R., Wanjari, U. R., Stany, B. K., Vellingiri, B., Madhyastha, H., Deepankumar, K., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102726 · Cited by 11 · see citing works
Park, G., Johnson, K., Miller, K., Kadyan, S., Singar, S., Patoine, C., Hao, F., Lee, Y., Patterson, A. D., Arjmandi, B. H., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00403-0 · Cited by 11 · see citing works
Linoleic acid, mitochondria, gut microbiome, and metabolic health: a mechanistic review
Mercola, J. M. (2025) · Advances in Redox Research · doi:10.1016/j.arres.2025.100128 · Cited by 11 · see citing works
Metabolite profiling of abalone (Haliotis iris) energy metabolism: a Chatham Islands case study
Venter, L., Alfaro, A. C., Nguyen, T. V., & Lindeque, J. Z. (2022) · Metabolomics · doi:10.1007/s11306-022-01907-6 · Cited by 11 · see citing works
Jatana, B. S., Kitchens, C. L., Ray, C. S., Gerard, P., & Tharayil, N. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04734 · Cited by 10 · see citing works
Lin, Z., Xue, M., Lu, M., Liu, S., Jiang, Y., Yang, Q., Cui, H., Huang, X., Zheng, Z., & Sun, B. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-11119-7 · Cited by 10 · see citing works
Hong, C., Guo, L., Wu, P., Ouyang, N., Zhang, X., Ma, H., & Qu, W. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107463 · Cited by 10 · see citing works
Pourmajidian, M., Hansen, J. Y., Shafiei, G., Mišić, B., & Dagher, A. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003619 · Cited by 11 · see citing works
Ngamkham, J., Siritutsoontorn, S., Saisomboon, S., Vaeteewoottacharn, K., & Jitrapakdee, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.966089 · Cited by 10 · see citing works
Gondáš, E., Trancikova, A. K., Šofránko, J., Majerová, P., Lučanský, V., Dohál, M., Kováč, A., & Murín, R. (2023) · Physiological Research · doi:10.33549/physiolres.935026 · Cited by 10 · see citing works
Ritterhoff, J., McMillen, T. S., Foundas, H., Palkovacs, R., Poschet, G., Caudal, A., Liu, Y., Most, P., Walker, M. A., & Tian, R. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00611.2023 · Cited by 9 · see citing works
Targeting farnesoid X receptor as aging intervention therapy
Zhang, L., Yu, J., Gao, X., Yan, Y., Wang, X., Shi, H., Fang, M., Liu, Y., Kim, Y., Zhu, H., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.006 · Cited by 12 · see citing works
Madaj, Z., Dahabieh, M. S., Kamalumpundi, V., Muhire, B. M., Pettinga, D., Siwicki, R. A., Ellis, A. E., Isaguirre, C. N., Galvis, M. L. E., DeCamp, L. M., et al. (2023) · RNA Biology · doi:10.1080/15476286.2023.2204586 · Cited by 9 · see citing works
Hybridization promotes growth performance by altering rumen microbiota and metabolites in sheep
Zhang, R., Zhang, L., An, X., Li, J., Niu, C., Zhang, J., Geng, Z., Xu, T., Yang, B., Xu, Z., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1455029 · Cited by 8 · see citing works
Metabolic Regulation of T Cell Exhaustion
Wu, H., Prados, M. C., & Vaeth, M. (2025) · Immune discovery. · doi:10.70322/immune.2025.10005 · Cited by 10 · see citing works
Comprehensive analysis of the effects of high stocking density stress on broiler health
Bai, D., Guo, C., Ma, P., Wang, Z., Zhao, X., Ma, X., Xie, X., Zhang, Y., Guo, F., Zhang, Y. Y., et al. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1741407 · Cited by 8 · see citing works
Song, K., Lee, H. S., Jia, L., Chelakkot, C., Rajasekaran, N., & Shin, Y. K. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.0067 · Cited by 8 · see citing works
Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum
Chen, J., Xu, W., Wang, Z., Li, T., Liu, W., Ren, A., Liu, R., Zhu, J. K., & Shi, L. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12357-4 · Cited by 8 · see citing works
Pissas, G., Tziastoudi, M., Divani, M., Poulianiti, C., Konsta, M. A. P., Lykotsetas, E., Liakopoulos, V., Stefanidis, I., & Eleftheriadis, T. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23854 · Cited by 7 · see citing works
Zhang, N., Li, X., Liu, X. Z., Chen, P., Li, L., Chai, Y., Cao, M., & Yang, Y. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177480 · Cited by 7 · see citing works
Peng, Y., Yan, L. E., Zhao, C., Zhang, B., Zhang, B., & Qiu, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178295 · Cited by 7 · see citing works
α-Ketoglutaric acid as a promising platform chemical for sustainable bio-based industries
Opsommer, L.-T. J. D., Schalck, T., Yogiswara, S., Verstrepen, K. J., Michiels, J. J., & Sels, B. F. (2025) · Chemical Society Reviews · doi:10.1039/d4cs01125b · Cited by 8 · see citing works
Qadri, S. F., Porthan, K., Dufour, S., Lehtimäki, T. E., Petersen, K. F., Shulman, G. I., Yki‐Järvinen, H., & Luukkonen, P. K. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.02.001 · Cited by 10 · see citing works
Gender-Specific Metabolomics Approach to Kidney Cancer
Deja, S., Litarski, A., Mielko, K. A., Pudełko‐Malik, N., Wojtowicz, W., Ząbek, A., Szydełko, T., & Młynarz, P. (2021) · Metabolites · doi:10.3390/metabo11110767 · Cited by 7 · see citing works
Cui, X., Anatolevna, S. T., & Wang, Y. (2024) · Metabolites · doi:10.3390/metabo14080433 · Cited by 7 · see citing works
Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis
Schindlmaier, K., Haitzmann, T., Bubalo, V., Konrad, B., Jelwan, J., Bluemel, G., Rittchen, S., Jäger, V., Dengler, M. A., Brčić, L., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2419568122 · Cited by 6 · see citing works
Lund, M., Heaton, R. A., Hargreaves, I. P., Gregersen, N., & Olsen, R. K. J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159248 · Cited by 6 · see citing works
Lipid Metabolism in Relation to Carbohydrate Metabolism
Akiki, P., Delamotte, P., & Montagne, J. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_821 · Cited by 6 · see citing works
Mitotyping – An integrative framework to quantify mitochondrial specialization and plasticityPreprint
Monzel, A. S., Devine, J., Kapri, D., Sturm, G., Trumpff, C., Menon, V., Jager, P. L. D., Enriquez, J. A., & Picard, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.03.635951 · Cited by 6 · see citing works
Wang, L., Liu, X., Chen, W., & Sun, Z. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115549 · Cited by 5 · see citing works
Diversified antibiotic resistance and sensitivity patterns induced by quaternary ammonium compounds
Yang, K., Lü, H., & Zhu, L. (2025) · Frontiers of Environmental Science & Engineering · doi:10.1007/s11783-025-2023-6 · Cited by 5 · see citing works
Ye, J.-R., Wang, H., Peng, Y., Wang, S., Zheng, R., Chen, Y., Yuan, R., Wang, Z., Xu, Y., He, W., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08309-1 · Cited by 5 · see citing works
Bertinat, R., Holyoak, T., Gatica, R., Jara, N., González‐Chavarría, I., & Westermeier, F. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102112 · Cited by 5 · see citing works
Wang, H., Bai, R., Pei, T., Meng, J., Nwanade, C. F., Zhang, Y., Liang, X., Tang, Y., Liu, J., & Yu, Z. (2025) · Parasites & Vectors · doi:10.1186/s13071-025-06718-x · Cited by 5 · see citing works
Biochemical production from sustainable carbon sources by Komagataella phaffii
Raja, W. A., & Çalı́k, P. (2025) · Biochemical Engineering Journal · doi:10.1016/j.bej.2025.109702 · Cited by 6 · see citing works
Tarantino, R., Jensen, H. M., & Waldman, S. D. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2024.03.119 · Cited by 5 · see citing works
Zhao, Z., Chen, H., Chen, W., Zhang, M., Pei, J., Lyu, Y., He, R., & Chen, W. (2026) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2026.111688 · Cited by 4 · see citing works
Xia, X., Wang, Y., Guo, Y., Wang, S., Long, M., Guo, J., & Fang, F. (2025) · Journal of Environmental Sciences · doi:10.1016/j.jes.2025.07.016 · Cited by 4 · see citing works
Jin, E. S., Wen, X., & Malloy, C. R. (2023) · NMR in Biomedicine · doi:10.1002/nbm.4994 · Cited by 4 · see citing works
Skeletal Muscle Metabolism Is Dynamic during Porcine Postnatal Growth
Rimmer, L. A., Geisbrecht, E. R., Chao, M. D., O’Quinn, T. G., Woodworth, J. C., & Zumbaugh, M. D. (2024) · Metabolites · doi:10.3390/metabo14070357 · Cited by 4 · see citing works
- Authors
- Inigo, M., Deja, S., & Burgess, S. C.
- Affiliations
- Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;
- The University of Texas Southwestern Medical Center (US)
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2021-10-11
- Volume
- 41
- Issue
- 1
- Pages
- 19-47
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W3178058019
- Cited by
- 189
- References
- 150
- Citations by year
- 2026: 48 · 2025: 56 · 2024: 35 · 2023: 33 · 2022: 15 · 2021: 2
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK128168, R01DK078184)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015908)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- TCA cycle, anaplerosis, cataplerosis, TCA cycle intermediates, biosynthetic precursors, catabolism, cellular energy status, redox state, oxidative capacity, tissue-specific metabolism, disease mechanisms
- MeSH terms
- Citric Acid Cycle, Humans, Oxidation-Reduction
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