The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Stereoisomeric Peptide Libraries and Peptidomimetics for Designing Selective Inhibitors of the αvβ3 Integrin for a New Cancer Therapy
Abstract
Cell–cell and cell–matrix interactions play a major role in biology. An important class of surface receptors are the integrins, which exist in a number of subtypes and are involved in many biological processes, for example embryonic development, blood coagulation, osteoporosis, cancer, and regulation of the balance between proliferation and death (apoptosis) of a cell. Therefore, selective inhibition of specific integrin subtypes is of great pharmaceutical interest. It is possible to develop highly selective and active inhibitors of integrins, especially the α v β 3 subtype, by the novel procedure of spatial screening. The resulting α v β 3 antagonists exhibit activity in the nanomolar range and suppress tumor‐induced angiogenesis (formation of new blood vessels). Tissues with intact blood vessels are not influenced. This opens a promising new way for cancer therapy.
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Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Induction of angiogenesis during the transition from hyperplasia to neoplasia
Folkman, J., Watson, K., Ingber, D., & Hanahan, D. (1989) · Nature · doi:10.1038/339058a0 · Cited by 1,879
Cited by
N -Methylated Cyclic RGD Peptides as Highly Active and Selective α V β 3 Integrin Antagonists
Dechantsreiter, M. A., Planker, E., Mathä, B., Lohof, E., Hölzemann, G., Jonczyk, A., Goodman, S. L., & Kessler, H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm970832g · Cited by 838
Self-citationExploring the Role of RGD-Recognizing Integrins in Cancer
Nieberler, M., Reuning, U., Reichart, F., Notni, J., Wester, H.-J., Schwaiger, M., Weinmüller, M., Räder, A., Steiger, K., & Kessler, H. (2017) · Cancers · doi:10.3390/cancers9090116 · Cited by 429
Self-citationLiu, S. (2009) · Bioconjugate Chemistry · doi:10.1021/bc900167c · Cited by 344
Are β-Amino Acids γ-Turn Mimetics? Exploring A New Design Principle for Bioactive Cyclopeptides
Schumann, F., Müller, A., Koksch, M., Müller, G., & Sewald, N. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0016001 · Cited by 102
Biscaglia, F., Ripani, G., Rajendran, S., Benna, C., Mocellin, S., Bocchinfuso, G., Meneghetti, M., Palleschi, A., & Gobbo, M. (2019) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b01392 · Cited by 54
Metadata
- Authors
- Haubner, R., Finsinger, D., & Kessler, H.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1997-08-04
- Volume
- 36
- Issue
- 13-14
- Pages
- 1374-1389
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W1995855261
- Cited by
- 430
- References
- 5
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haubner, R., Finsinger, D., & Kessler, H. (1997). Stereoisomeric Peptide Libraries and Peptidomimetics for Designing Selective Inhibitors of the αvβ3 Integrin for a New Cancer Therapy. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.199713741
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