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The Staudinger Ligation—A Gift to Chemical Biology
Abstract
Although the reaction between an azide and a phosphane to form an aza‐ylide was discovered by Hermann Staudinger more than 80 years ago and has found widespread application in organic synthesis, its potential as a highly chemoselective ligation method for the preparation of bioconjugates has been recognized only recently. As the two reaction partners are bioorthogonal to almost all functionalities that exist in biological systems and react at room temperature in an aqueous environment, the Staudinger ligation has even found application in the complex environment of living cells. Herein we describe the current state of knowledge on this reaction and its application both for the preparation of bioconjugates and as a ligation method in chemical biology.
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Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
Cited by
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Homaei, A. A., Sariri, R., Vianello, F., & Stevanato, R. (2013) · Journal of Chemical Biology · doi:10.1007/s12154-013-0102-9 · Cited by 875
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
Agrahari, A. K., Bose, P., Jaiswal, M. K., Rajkhowa, S., Singh, A. S., Hotha, S., Mishra, N., & Tiwari, V. K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00920 · Cited by 445
Semisynthetic DNA–Protein Conjugates for Biosensing and Nanofabrication
Niemeyer, C. M. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200904930 · Cited by 369
Umpolung reactivity in amide and peptide synthesis
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Metadata
- Authors
- Köhn, M., & Breinbauer, R.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-06-09
- Volume
- 43
- Issue
- 24
- Pages
- 3106-3116
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2052859437
- Cited by
- 585
- References
- 1
- FWCI
- 17.58
- Type
- journal article
- Language
- en
- Open access
- closed
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