Nonviral vectors for gene delivery

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

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Introduction and General Overview of Cyclodextrin Chemistry

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Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

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Direct Gene Transfer into Mouse Muscle in Vivo

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A New Class of Polymers: Starburst-Dendritic Macromolecules

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Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art

Müller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,759 · see citing works

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.

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A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

Vivès, É., Brodin, P. M., & Lebleu, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.16010 · Cited by 2,377 · see citing works

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis

Fischer, D., Li, Y., Ahlemeyer, B., Krieglstein, J., & Kissel, T. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00445-3 · Cited by 2,329 · see citing works

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

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The third helix of the Antennapedia homeodomain translocates through biological membranes.

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Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation

Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton‐Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988 · see citing works

Lysosomotropic Agents

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Gene therapy - promises, problems and prospects

Verma, I. M., & Somia, N. (1997) · Nature · doi:10.1038/38410 · Cited by 1,681 · see citing works

High-velocity microprojectiles for delivering nucleic acids into living cells

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Quantum Dots as Cellular Probes

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Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

Akinc, A., Thomas, M., Klibanov, A. M., & Langer, R. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.696 · Cited by 1,339 · see citing works

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

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Fluorescence Resonance Energy Transfer Between Quantum Dot Donors and Dye-Labeled Protein Acceptors

Clapp, A. R., Medintz, I. L., Mauro, J. M., Fisher, B. R., Bawendi, M. G., & Mattoussi, H. M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja037088b · Cited by 1,302 · see citing works

A Novel Non-Viral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity

Fischer, D., Bieber, T., Li, Y., Elsässer, H., & Kissel, T. (1999) · Pharmaceutical Research · doi:10.1023/a:1014861900478 · Cited by 1,219 · see citing works

Mechanics of receptor-mediated endocytosis

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Dectin-1 Mediates the Biological Effects of β-Glucans

Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. J., & Gordon, S. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021890 · Cited by 1,209 · see citing works

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

Haensler, J., & Szoka, F. C. (1993) · Bioconjugate Chemistry · doi:10.1021/bc00023a012 · Cited by 1,208 · see citing works

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178 · see citing works

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection,

Xu, Y., & Szoka, F. C. (1996) · Biochemistry · doi:10.1021/bi9602019 · Cited by 1,136 · see citing works

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

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Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery

Pantarotto, D., Singh, R. N., McCarthy, D., Erhardt, M., Briand, J., Prato, M., Kostarelos, K., & Bianco, A. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460437 · Cited by 1,093 · see citing works

Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

Sonawane, N. D., Szoka, F. C., & Verkman, A. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308643200 · Cited by 1,083 · see citing works

Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent

Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., & Prochiantz, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18188 · Cited by 1,073 · see citing works

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson’s disease: an open label, phase I trial

Kaplitt, M. G., Feigin, A., Tang, C., Fitzsimons, H. L., Mattis, P., Lawlor, P. A., Bland, R. J., Young, D., Strybing, K., Eidelberg, D., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60982-9 · Cited by 1,067 · see citing works

Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers.

Kukowska‐Latallo, J. F., Bielinska, A. U., Johnson, J., Spindler, R., Tomalia, D. A., & Baker, J. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4897 · Cited by 1,006 · see citing works

Cationic liposome-mediated transfection

Felgner, P. L., & RINGOLD, G. M. (1989) · Nature · doi:10.1038/337387a0 · Cited by 989 · see citing works

High-efficiency gene transfer into skeletal muscle mediated by electric pulses.

Mir, L. M., Bureau, M., Gehl, J., Rangara, R., Rouy, D., Caillaud, J., Delaère, P., Branellec, D., Schwartz, B., & Scherman, D. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.8.4262 · Cited by 972 · see citing works

Hemilability of Hybrid Ligands and the Coordination Chemistry of Oxazoline-Based Systems

Braunstein, P., & Naud, F. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010216)40:4 · Cited by 951 · see citing works

The proton sponge: a trick to enter cells the viruses did not exploit

Behr, J.-P. (1997) · CHIMIA · doi:10.2533/chimia.1997.34 · Cited by 933 · see citing works

Degradable poly (β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA

Lynn, D. M., & Langer, R. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0015388 · Cited by 924 · see citing works

Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans.

Nabel, G. J., Nabel, E. G., Yang, Z., Fox, B. A., Plautz, G. E., Gao, X., Huang, L., Shu, S., Gordon, D., & Chang, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11307 · Cited by 882 · see citing works

Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives

Neu, M., Fischer, D., & Kissel, T. (2005) · The Journal of Gene Medicine · doi:10.1002/jgm.773 · Cited by 866 · see citing works

The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent

Desai, M. P., Labhasetwar, V., Walter, E., Levy, R. J., & Amidon, G. L. (1997) · Pharmaceutical Research · doi:10.1023/a:1012126301290 · Cited by 858 · see citing works

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

Wu, G. Y., & Wu, C. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61209-8 · Cited by 855 · see citing works

A novel cationic liposome reagent for efficient transfection of mammalian cells

Gao, X., & Huang, L. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91366-k · Cited by 847 · see citing works

A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent

Radu, D. R., Lai, C., Jeftinija, K., Rowe, E., Jeftinija, S., & Lin, V. S. ‐. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046275m · Cited by 840 · see citing works

Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery

Godbey, W. T., Wu, K. K., & Mikos, A. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5177 · Cited by 823 · see citing works

The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

Tang, M., & Szoka, F. C. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300454 · Cited by 814 · see citing works

Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine

Kunath, K. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00076-2 · Cited by 809 · see citing works

In Vitro Gene Delivery by Degraded Polyamidoamine Dendrimers

Tang, M. X., Redemann, C. T., & Szoka, F. C. (1996) · Bioconjugate Chemistry · doi:10.1021/bc9600630 · Cited by 809 · see citing works

Functionalization of Carbon Nanotubes via Cleavable Disulfide Bonds for Efficient Intracellular Delivery of siRNA and Potent Gene Silencing

Kam, N. W. S., Liu, Z., & Dai, H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja053962k · Cited by 790 · see citing works

Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells

Vinogradov, S. V., Bronich, T. K., & Kabanov, A. V. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00245-9 · Cited by 776 · see citing works

Evidence for the role of proteoglycans in cation-mediated gene transfer.

Mislick, K. A., & Baldeschwieler, J. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12349 · Cited by 774 · see citing works

Binding and Condensation of Plasmid DNA onto Functionalized Carbon Nanotubes: Toward the Construction of Nanotube-Based Gene Delivery Vectors

Singh, R. N., Pantarotto, D., McCarthy, D., Chaloin, O., Hoebeke, J., Partidos, C. D., Briand, J., Prato, M., Bianco, A., & Kostarelos, K. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0441561 · Cited by 759 · see citing works

Trojan peptides: the penetratin system for intracellular delivery

Derossi, D., Chassaing, G., & Prochiantz, A. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)80017-2 · Cited by 725 · see citing works

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

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Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

Caplen, N. J., Alton, E. W. F. W., Mddleton, P. G., Dorin, J. R., Stevenson, B. J., Gao, X., Durham, S. R., Jeffery, P. K., Hodson, M. E., Coutelle, C. C., et al. (1995) · Nature Medicine · doi:10.1038/nm0195-39 · Cited by 710 · see citing works

Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 696 · see citing works

Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus

Sodeik, B., Ebersold, M. W., & Helenius, A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1007 · Cited by 687 · see citing works

Cell penetration by transportan

Pooga, M., Hällbrink, M., Zorko, M., & Langel, U. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.67 · Cited by 680 · see citing works

siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters

Liu, Z., Winters, M. A., Holodniy, M., & Dai, H. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604295 · Cited by 666 · see citing works

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

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The β-Glucan Receptor, Dectin-1, Is Predominantly Expressed on the Surface of Cells of the Monocyte/Macrophage and Neutrophil Lineages

Taylor, P. R., Brown, G. D., Reid, D. M., Willment, J. A., Martínez‐Pomares, L., Gordon, S., & Wong, S. Y. C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3876 · Cited by 655 · see citing works

A triploblast origin for Myxozoa?

Anderson, C. L., Canning, E. U., & Okamura, B. (1998) · Nature · doi:10.1038/32801 · Cited by 654 · see citing works

Antennapedia homeobox peptide regulates neural morphogenesis.

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Lipid-based Nanoparticles for Nucleic Acid Delivery

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Receptor-mediated gene delivery and expression in vivo.

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Mechanism of oligonucleotide release from cationic liposomes.

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Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

Lechardeur, D., Sohn, K.-J., Haardt, M., Joshi, P. B., Monck, M. A., Graham, R. W., Beatty, B., Squire, J. A., O'Brodovich, H. M., & Lukács, G. L. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300867 · Cited by 632 · see citing works

Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

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Gene therapy clinical trials worldwide to 2007—an update

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Organically modified silica nanoparticles: A nonviral vector for in vivo gene delivery and expression in the brain

Bharali, D. J., Klejbor, I., Stachowiak, E. K., Dutta, P., Roy, I., Kaur, N., Bergey, E. J., Prasad, P. N., & Stachowiak, M. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504926102 · Cited by 622 · see citing works

Cationic liposome-mediated gene transfer.

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Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

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Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery

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In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.

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Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

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Size-dependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles

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Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing

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Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells

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Enhancement of transfection by physical concentration of DNA at the cell surface

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Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics

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Chitosan-Based Vector/DNA Complexes for Gene Delivery: Biophysical Characteristics and Transfection Ability

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Chitosans for gene delivery

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A new peptide vector for efficient delivery of oligonucleotides into mammalian cells

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Polyethylenimine-graft-Poly(ethylene glycol) Copolymers: Influence of Copolymer Block Structure on DNA Complexation and Biological Activities as Gene Delivery System

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Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

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Characterization of commercially available and synthesized polyethylenimines for gene delivery

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Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

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Semi‐Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery

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Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes

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DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

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Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

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Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

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Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

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Water-Soluble Polyion Complex Associates of DNA and Poly(ethylene glycol)−Poly( l -lysine) Block Copolymer

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Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery

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Chemical Approaches to Triggerable Lipid Vesicles for Drug and Gene Delivery

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Efficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine

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A Columnar Phase of Dendritic Lipid−Based Cationic Liposome−DNA Complexes for Gene Delivery: Hexagonally Ordered Cylindrical Micelles Embedded in a DNA Honeycomb Lattice

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Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure–activity relationships in vitro

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Novel Branched Poly(Ethylenimine)−Cholesterol Water-Soluble Lipopolymers for Gene Delivery

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Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers

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Synthesis, Activity, and Structure−Activity Relationship Studies of Novel Cationic Lipids for DNA Transfer

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Determination of the Upper Size Limit for Uptake and Processing of Ligands by the Asialoglycoprotein Receptor on Hepatocytesin Vitro and in Vivo

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Hydroxyl Stereochemistry and Amine Number within Poly(glycoamidoamine)s Affect Intracellular DNA Delivery

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Integrin targeting using RGD‐PEI conjugates for in vitro gene transfer

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Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. II. Implications for membrane-membrane interactions and membrane fusion

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Crystal Design of Barium Sulfate using Double-Hydrophilic Block Copolymers

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The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA

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Enhancement of Gene Expression by Polyamidoamine Dendrimer Conjugates with α-, β-, and γ-Cyclodextrins

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Molecular Recognition of Adenine, Cytosine, and Uracil in a Single-Stranded RNA by a Natural Polysaccharide: Schizophyllan

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Non-viral vectors for gene-based therapy

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mRNA vaccines for infectious diseases: principles, delivery and clinical translation

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In vitro and ex vivo strategies for intracellular delivery

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mRNA vaccine delivery using lipid nanoparticles

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CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

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Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

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Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-Carriers

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Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

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Challenges in CRISPR/CAS9 delivery: potential roles of nonviral vectors

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Strategies for nonviral nanoparticle‐based delivery of CRISPR/Cas9 therapeutics

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Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging

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Induction of genuine autophagy by cationic lipids in mammalian cells

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Multifunctional "core-shell" nanoparticles-based gene delivery for treatment of aggressive melanoma

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Drug Delivery Across the Blood–Brain Barrier: A New Strategy for the Treatment of Neurological Diseases

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Small interfering RNAs (siRNAs) based gene silencing strategies for the treatment of glaucoma: Recent advancements and future perspectives

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The road towards gene therapy for X-linked juvenile retinoschisis: a systematic review of preclinical gene therapy in cell-based and rodent models of xlrs

van der Veen, I., Heredero Berzal, A., Koster, C., ten Asbroek, A. L. M. A., Bergen, A. A., & Boon, C. J. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021267 · Cited by 14 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

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From attention to citation: What are altmetrics and how do they work?

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Icon «The Judgment of the Jews over Christ» of the First Half of the XIX Century

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Do Altmetrics Work? Twitter and Ten Other Social Web Services

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