The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Inhibitors of Protein Tyrosine Phosphatases: Next‐Generation Drugs?
Abstract
The protein tyrosine phosphatases (PTPs) constitute a family of closely related key regulatory enzymes that dephosphorylate phosphotyrosine residues in their protein substrates. Malfunctions in PTP activity are linked to various diseases, ranging from cancer to neurological disorders and diabetes. Consequently, PTPs have emerged as promising targets for therapeutic intervention in recent years. In this review, general aspects of PTPs and the development of small‐molecule inhibitors of PTPs by both academic research groups and pharmaceutical companies are discussed. Different strategies have been successfully applied to identify potent and selective inhibitors. These studies constitute the basis for the future development of PTP inhibitors as drugs.
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Cites
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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
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Protein Kinase Inhibitors: Insights into Drug Design from Structure
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Cited by
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors
Sarver, P., Acker, M., Bagdanoff, J. T., Chen, Z., Chen, Y.-N., Chan, H., Firestone, B., Fodor, M., Fortanet, J., Hao, H., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01726 · Cited by 87
Metadata
- Authors
- Bialy, L., & Waldmann, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2005-06-10
- Volume
- 44
- Issue
- 25
- Pages
- 3814-3839
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2147310438
- Cited by
- 420
- References
- 164
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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