Signaling—2000 and Beyond
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Microglial Nox1 and Nox2 target different redox-sensitive signaling compounds, possibly because of differences in the subcellular distributions of catalytically active Nox and LPS-signaling components.
“differential effects of Nox proteins in microglial expression of IL-1 and iNOS genes suggest that microglial Nox1 and Nox2 target different redoxsensitive signaling compounds, possibly because of differences in the subcellular distributions of catalytically active Nox and LPSsignaling components (Hunter, 2000).”
From Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase (2008) · cites this paper as Hunter, 2000
The section “Spatiotemporal Aspects of Signaling” (page unavailable) says that the location of signaling components can determine signaling specificity, supporting the proposed spatial mechanism in general. It does not address microglial Nox1 or Nox2, their redox-sensitive targets, or LPS-signaling components, so it does not support the specific application to them. (LLM, conf=0.82)
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- Authors
- Hunter, T.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Hunter, Tony
- ORCID
- Hunter, Tony
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 100
- Issue
- 1
- Pages
- 113-127
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2042629507
- Cited by
- 2,586
- References
- 5
- Citations by year
- 2026: 34 · 2025: 40 · 2024: 43 · 2023: 39 · 2022: 47 · 2021: 43 · 2020: 41 · 2019: 55 · 2018: 70 · 2017: 93 · 2016: 69 · 2015: 101 · 2014: 91 · 2013: 100 · 2012: 119
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- signal transduction, G proteins, cyclic AMP, protein kinase A, second messengers, transmembrane signaling, protein phosphorylation, protein kinases, protein phosphatase, adenylate cyclase, receptor tyrosine kinase, MAP kinase cascade, MAP3K, MEK, mitogen-activated protein kinase, cancer signaling
- MeSH terms
- Animals, Biology, Forecasting, Humans, Signal Transduction, History, 20th Century
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